Strain Information | |
---|---|
Image | |
BRC No. | RBRC05278 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | mHB-EGF (Acc. No.CDB0447T) |
Former Common name | |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Masato Kasuga, Kobe University Graduate School of Medicine. |
Strain description | mHB-EGF transgenic mice. This transgenic mouse expresses HB-EGF in skeletal muscle under the control of the mouse MCK promoter-enhancer. Tg mice were protected from obesity, hepatic steatosis and insulin resistance when maintained on a high-fat diet. |
Colony maintenance | Carrier x Noncarrier [C57BL/6N] |
References | Endocrinology, 150, 2683-2691 (2009). 19264873 |
Health Report | |
---|---|
Examination Date / Room / Rack |
Gene | |
---|---|
Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Hbegfheparin-binding epidermal growth factor-like growth factor (mouse)UNHbegfmouse MCK promoter and enhancer Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter catE. coli chloramphenicol acetyltransferase (CAT)UN Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter SV40 intronUN |
Ordering Information | |
---|---|
Donor DNA | マウス (MCK promoter and enhancer), マウス (HB cDNA), SV40 (イントロン領域), 大腸菌 (CAT), mouse HB-EGF |
Research application | |
Specific Term and Conditions | (1) The RECIPIENT shall obtain a prior agreement from the DEVELOPER (Dr. Masato Kasuga, Kobe University, E-mail: kasuga@ri.imcj.go.jp) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Acc.No. CDB0447T and Web. Site (https://large.riken.jp/distribution/mutant-list.html) is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested. (Endocrinology. 2009 150(6):2683-91.) (4) Please inform the DEPOSITOR (mutant.bdr@riken.jp) about the paper when published. |
Depositor | RIKEN CDB (RIKEN CDB) |
Strain Status | Frozen embryos |
Strain Availability | Recovery and QC required prior to distribution |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
---|
No Data |