Strain Data Sheet

RBRC05548

Strain Information

Image
BRC No.RBRC05548
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameSLW
Former Common name
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Tetsuo Kunieda, Faculty of Agriculture, Okayama University. Spontaneous mutation arose in ddY mouse colony. The mutant mouse was crossed with C57BL/6J, and maintained by sister-brother maintaining.
Strain descriptionShort-limbed dwarfism, SLW mice. Spontaneous mutation arose in ddY mouse colony. Homozygous mice show dwarfism and most of them die before weaning. A 7-base deletion was identified in exon 8 of the Npr2 gene, resulting in a frameshift and premature termination codon appearance.
Colony maintenanceHeterozygote x Wild-type
ReferencesAm. J. Pathol., 177, 822-888 (2010). 20616347
J. Hered., 98, 575-580 (2007). 17728275

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Npr2natriuretic peptide receptor 24Npr2<slw>short-limbed dwarfism

Ordering Information

Donor DNA
Research applicationMouse Models for Human Disease
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Am. J. Pathol., 177, 822-888 (2010). Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR.
DepositorTetsuo Kunieda (Okayama University)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityLive mouse (3 to 6 months)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

No Data