Strain Information | |
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Image | |
BRC No. | RBRC06394 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6;129P2-Fbxw7<tm1Kin> |
Former Common name | Fbxw7 KO, B6-Fbxw7 KO |
H-2 Haplotype | |
ES Cell line | E14 [129P2/OlaHsd] |
Background strain | |
Appearance | |
Strain development | Developed by Keiichi Nakayama, Medical Institute of Bioregulation, Kyushu University. E14 ES cells were used. The mutant mice were crossed to C57BL/6J over 7 times. |
Strain description | Fbxw7 gene knockout mice. Exons 1 to 5 was replaced with PGK-neo (loxP-neo) cassette. |
Colony maintenance | Heterozygote x Wild-type [C57BL/6JJcl] |
References | J. Biol. Chem., 279, 9417-9423 (2004). 14672936 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP3loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP3loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)3mouse phosphoglycerate kinase promoter (PGK promoter) Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter SV40 polyA signal3 |
Ordering Information | |
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Donor DNA | E. coli Neomycin resistance gene, mouse phosphoglycerate kinase promoter, SV40 polyA signal, phage P1 loxP |
Research application | Hematological Research |
Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR. |
Depositor | Keiichi Nakayama (Kyushu University) |
Strain Status | Frozen embryos |
Strain Availability | Recovery and QC required prior to distribution |
Additional Info. | Necessary documents for ordering:
Mouse of the Month Jan 2015 |
BRC mice in Publications |
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No Data |