Strain Information | |
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Image | |
BRC No. | RBRC10286 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | C57BL/6-Erp44<tm1Kmik> |
Former Common name | ERp44 knockout mice |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Katsuhiko Mikoshiba and Chihiro Hisatsune, RIKEN Brain Science Institute in 2015. ES cells derived from C57BL/6 were used. |
Strain description | Erp44 (endoplasmic reticulum protein 44) knockout mice. Exon 2 and 3 were replaced with the Neo gene fragment. Homozygous mutants in the C57BL/6 die within 24 hours after birth. Mutant in a mixed genetic background (FVB/NJ X C57BL/6) can survive but exhibit low blood pressure. |
Colony maintenance | |
References | Cell, 120(1):85-98 (2005). 15652484 Mol Cell., 58(6):1015-1027 (2015). 25959394 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene4mouse phosphoglycerate kinase promoter (PGK promoter) |
Ordering Information | |
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Donor DNA | 大腸菌 ネオマイシン耐性遺伝子, マウス pgk1-promoter(0.2 kb), Mouse PGK pA配列 |
Research application | |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Mol Cell. Jun 18;58(6):1015-1027(2015). Cell. Jan 14;120(1):85-98.(2005). The RECIPIENT of BIOLOGICAL RESOURCE must use it as a collaborative study with DEPOSITOR. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Katsuhiko Mikoshiba (RIKEN) |
Strain Status | Frozen embryos |
Strain Availability | Recovery and QC required prior to distribution |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |