Strain Data Sheet

RBRC10288

Strain Information

Image
BRC No.RBRC10288
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129S4-Itpr1<tm1Tno>
Former Common nameIP3R1 knockout mice
H-2 Haplotype
ES Cell lineJ1 [129S4/SvJae]
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Katsuhiko Mikoshiba, RIKEN Brain Science Institute in 1996. J1 ES cells derived from 129S4/SvJae were used. Mixed genetic background by crossing with C57BL/6 for 2 generations.
Strain descriptionItpr1 (inositol 1,4,5-trisphosphate receptor 1) KO mouse. A Neo gene fragment was inserted to the exon containing translation initiation codon. Homozygous mutant exhibit severe ataxia, seizures, and lethality by weaning age. Mixed genetic background.
Colony maintenance
ReferencesNature, 379(6561)168-171 (1996). 8538767

Health Report

Examination Date / Room / Rack2024/01/22Room:3-CRack:C

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Itpr1inositol 1,4,5-trisphosphate receptor 16Itpr1<tm1Tno>targeted mutation 1, Tetsuo Noda

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene6mouse phosphoglycerate kinase promoter (PGK promoter)

Ordering Information

Donor DNAMouse PGK promoter, Escherichia coli neomycin-resistant gene, Mouse PGK pA, Mouse Itpr1 genomic DNA
Research application
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE must use it as a collaborative study with DEPOSITOR. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
DepositorKatsuhiko Mikoshiba (RIKEN)
Strain Statusan icon for Live miceLive mice
an icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityCryopreserved sperm (within 1 month)
Live mouse (more than 6 months)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

No Data