Strain Information | |
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Image | |
BRC No. | RBRC10288 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6;129S4-Itpr1<tm1Tno> |
Former Common name | IP3R1 knockout mice |
H-2 Haplotype | |
ES Cell line | J1 [129S4/SvJae] |
Background strain | C57BL/6JJcl |
Appearance | |
Strain development | Developed by Katsuhiko Mikoshiba, RIKEN Brain Science Institute in 1996. J1 ES cells derived from 129S4/SvJae were used. Mixed genetic background by crossing with C57BL/6 for 2 generations. |
Strain description | Itpr1 (inositol 1,4,5-trisphosphate receptor 1) KO mouse. A Neo gene fragment was inserted to the exon containing translation initiation codon. Homozygous mutant exhibit severe ataxia, seizures, and lethality by weaning age. Mixed genetic background. |
Colony maintenance | |
References | Nature, 379(6561)168-171 (1996). 8538767 |
Health Report | |
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Examination Date / Room / Rack | 2024/01/22Room:3-CRack:C |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene6mouse phosphoglycerate kinase promoter (PGK promoter) |
Ordering Information | |
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Donor DNA | Mouse PGK promoter, Escherichia coli neomycin-resistant gene, Mouse PGK pA, Mouse Itpr1 genomic DNA |
Research application | |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE must use it as a collaborative study with DEPOSITOR. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Katsuhiko Mikoshiba (RIKEN) |
Strain Status | Live mice Frozen embryos Frozen sperm |
Strain Availability | Cryopreserved sperm (within 1 month) Live mouse (more than 6 months) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |