Strain Information | |
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Image | |
BRC No. | RBRC10290 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.129-Itpr3<tm1Kmik> |
Former Common name | IP3R3 knockout mice |
H-2 Haplotype | |
ES Cell line | R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>] |
Background strain | C57BL/6JJcl |
Appearance | |
Strain development | Developed by Katsuhiko Mikoshiba, RIKEN Brain Science Institute in 2005. R1 ES cells derived from (129X1/SvJ x 129S1/Sv)F1 were used. C57BL/6J congenic line by crossing with C57BL/6 for 10 generations. |
Strain description | Itpr3 (inositol 1,4,5-trisphosphate receptor 3) KO mouse. A nls-LacZ gene fragment was inserted downstream of the translation initiation codon. Homozygous mutant exhibit abnormal hair loss and low sweet preference. |
Colony maintenance | |
References | J. Invest. Dermatol., 132(9) 2137-2147 (2012). 22572820 Science, 309(5744) 2232-2234 (2005). 16195467 Eur. J. Neurosci., 27(10) 2665-2675 (2008). 18547250 |
Health Report | |
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Examination Date / Room / Rack | 2024/01/22Room:3-CRack:D |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene17mouse phosphoglycerate kinase promoter (PGK promoter) |
Ordering Information | |
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Donor DNA | Mouse PGK promoter, Escherichia coli neomycin-resistant gene, mouse PGK pA, Mouse Itpr3 genomic DNA |
Research application | |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE must use it as a collaborative study with DEPOSITOR. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Katsuhiko Mikoshiba (RIKEN) |
Strain Status | Live mice Frozen sperm |
Strain Availability | Cryopreserved sperm (within 1 month) Live mouse (more than 6 months) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |