Strain Information | |
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Image | |
BRC No. | RBRC10293 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | C57BL/6-Itpr2<tm2.1Kmik> |
Former Common name | Itpr2 floxed mice |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Katsuhiko Mikoshiba, RIKEN Brain Science Institute in 2018. ES cells derived from C57BL/6 were used. |
Strain description | Itpr2 (inositol 1,4,5-trisphosphate receptor 2) floxed mice. A neo gene fragment was removed by crossing with a Flp mouse line. |
Colony maintenance | |
References | J. Clin. Invest., 124(11) 4773-4780 (2014). 25329695 |
Health Report | |
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Examination Date / Room / Rack | 2022/07/11Room:3-BRack:L 2022/04/11Room:3-BRack:L |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Itpr2inositol 1,4,5-triphosphate receptor 26Itpr2<tm2.1Kmik>targeted mutation 2.1, Katsuhiko Mikoshiba Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Frtyeast FRT (flippase recombination target) site6Frt Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP6loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP6loxP |
Ordering Information | |
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Donor DNA | phage P1 loxP sites, yeast FRT (flipase recombination target) site, mouse Itpr2 genomic DNA |
Research application | Cre/loxP system FLP/frt system |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE must use it as a collaborative study with DEPOSITOR. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Katsuhiko Mikoshiba (RIKEN) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Zhang M, Zhi N, Feng J, Liu Y, Zhang M, Liu D, Yuan J, Dong Y, Jiang S, Ge J, Wu S, Zhao X. ITPR2 Mediated Calcium Homeostasis in Oligodendrocytes is Essential for Myelination and Involved in Depressive-Like Behavior in Adolescent Mice. Adv Sci (Weinh) e2306498(2024) 38476116 |