Strain Information | |
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Image | |
BRC No. | RBRC10791 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.Cg-Prox1<tm1.1Ykaw> |
Former Common name | |
H-2 Haplotype | |
ES Cell line | Bruce 4 [B6.Cg-Thy1<a>] |
Background strain | |
Appearance | |
Strain development | Deposited by Yoshiya Kawaguchi, Kyoto University in 2019. Bruce4 ES cells were used to generate this strain. Mice were crossed with C57BL/6J. |
Strain description | Floxed Prox1 mice. A pair of loxP flanks Exon 2 of the Prox1 gene. |
Colony maintenance | |
References | FEBS Lett., 591(4):624-635 (2017). 28129664 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Frtyeast FRT (flippase recombination target) site1Frt Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP1loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP1loxP |
Ordering Information | |
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Donor DNA | Bacteriophage P1 LoxP sites, yeast FRT (flippase recombination target) site, mouse Prox1 genomic DNA |
Research application | Cre/loxP system FLP/frt system |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. FEBS Lett., 591(4):624-635 (2017). |
Depositor | Yoshiya Kawaguchi (Kyoto University) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Lin Q, Wu L, Chatla S, Chowdhury FA, Atale N, Joseph J, Du W. Hematopoietic stem cell regeneration through paracrine regulation of the Wnt5a/Prox1 signaling axis. J Clin Invest 132(12) (2022) 35703178 |