RBRC00094, C3H-fBi-Rb(6.15)

RBRC No. RBRC00094
Type Chromosomal Aberration 12wks,♂
Species Mus musculus
Strain name C3H-fBi-Rb(6.15)
Former Common name No Data
H-2 Haplotype No Data
Background strain C3H
Appearance
1 Appearance agouti
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Rb(6.15)1Ald
Symbol name Robertsonian translocation, Chr 6 and 15
Chromosome 15
Common name Rb1Ald
Symbol description No Data
2 Symbol Rb(6.15)1Ald
Symbol name Robertsonian translocation, Chr 6 and 15
Chromosome 6
Common name Rb1Ald
Symbol description No Data
References No Data

Research applications Genetics Research
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Shisa, Hayase (Saitama Cancer Center) Shisa, Hayase
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00134, C57BL/6-Lyst<bg-J>/StmRbrc

RBRC No. RBRC00134
Type Spontaneous Mutation Congenic wks
Species Mus musculus
Strain name C57BL/6-Lyst<bg-J>/StmRbrc
Former Common name C57BL/6-bg/bg
H-2 Haplotype b
Background strain C57BL/6J
Appearance
1 Appearance light black
Genotype aaBBCC;bgJ/bgJ
Strain development Jackson Laboratory – Aichi Cancer Center Research Institute (1973?) – Saitama Cancer Center (1977, F16).
Strain description Beige spontaneous mutant mice. Homozygous mutant mice snow a phenotype similar to human Chediak-Higashi syndrome.
Colony maintenance Homozygote x Homozygote
Health Report
Gene Details
Promoter No Data
1 Symbol Lyst
Symbol name lysosomal trafficking regulator
Chromosome 13
Common name beige, bg, D13Sfk13
Symbol description No Data
References Nature. 1996 Jul 18;382(6588):262-5.

Identification of the homologous beige and Chediak-Higashi syndrome genes.
Research applications Dermatology Research,
Hematological Research,
Immunology and Inflammation Research,
Internal/Organ Research,
Metabolism Research,
Mouse Models for Human Disease
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Shisa, Hayase (Saitama Cancer Center) Shisa, Hayase
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00135, C57BL/6J-bg/bg- Foxn1 nu

RBRC No. RBRC00135
Type Spontaneous Mutation Congenic
Species Mus musculus
Strain name C57BL/6J-bg/bg-Foxn1nu
Former Common name No Data
H-2 Haplotype No Data
Background strain C57BL/6J
Appearance
1 Appearance black
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Foxn1
Symbol name forkhead box N1
Chromosome 11
Common name D11Bhm185e, Hfh11, whn
Symbol description No Data
2 Symbol Lyst
Symbol name lysosomal trafficking regulator
Chromosome 13
Common name beige, bg, D13Sfk13
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Shisa, Hayase (Saitama Cancer Center) Shisa, Hayase
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00151, DDY/Stm

RBRC No. RBRC00151
Type Inbred
Species Mus musculus
Strain name DDY/Stm
Former Common name No Data
H-2 Haplotype No Data
Background strain DDY/Stm
Appearance
1 Appearance albino
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Fubi1
Symbol name failure of ureteric bud invasion 1
Chromosome 2
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Shisa, Hayase (Saitama Cancer Center) Shisa, Hayase
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Live
Live mouse :

RBRC00173, CBA/H

RBRC No. RBRC00173
Type Inbred
Species Mus musculus
Strain name CBA/H
Former Common name No Data
H-2 Haplotype k
Background strain CBA/HStm
Appearance
1 Appearance agouti
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name No Data
Chromosome No Data
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Shisa, Hayase (Saitama Cancer Center) Shisa, Hayase
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00174, CBA/CaH-T(14;15)6Ca

RBRC No. RBRC00174
Type Chromosomal Aberration
Species Mus musculus
Strain name CBA/CaH-T(14;15)6Ca
Former Common name CBA/H-T6-Rb(14.15); CBA T6 translocation-Rb(14.15);
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol T(14;15)6Ca
Symbol name reciprocal translocation, Chr 14 and 15, Carter 6
Chromosome 14
Common name T6Ca
Symbol description No Data
2 Symbol T(14;15)6Ca
Symbol name reciprocal translocation, Chr 14 and 15, Carter 6
Chromosome 15
Common name T6Ca
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Shisa, Hayase (Saitama Cancer Center) Shisa, Hayase
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00175, CBA/H-T(14;15)6Ca- Foxn1 nu

RBRC No. RBRC00175
Type Spontaneous Mutation 4wks
Species Mus musculus
Strain name CBA/H-T(14;15)6Ca-Foxn1nu
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Foxn1
Symbol name forkhead box N1
Chromosome 11
Common name D11Bhm185e, Hfh11, whn
Symbol description No Data
2 Symbol T(14;15)6Ca
Symbol name reciprocal translocation, Chr 14 and 15, Carter 6
Chromosome 14
Common name T6Ca
Symbol description No Data
3 Symbol T(14;15)6Ca
Symbol name reciprocal translocation, Chr 14 and 15, Carter 6
Chromosome 15
Common name T6Ca
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Shisa, Hayase (Saitama Cancer Center) Shisa, Hayase
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00216, RFM/Ms

RBRC No. RBRC00216
Type Inbred 24wks,♂
Species Mus musculus
Strain name RFM/Ms
Former Common name No Data
H-2 Haplotype No Data
Background strain RFM/MsStm
Appearance
1 Appearance albino
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name No Data
Chromosome No Data
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Shisa, Hayase (Saitama Cancer Center) Shisa, Hayase
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00217, RFM/Ms-Rb(6.15)

RBRC No. RBRC00217
Type Chromosomal Aberration
Species Mus musculus
Strain name RFM/Ms-Rb(6.15)
Former Common name No Data
H-2 Haplotype No Data
Donor strain AKR/J-Rb(6.15)1Ald
Background strain RFM/Ms
Appearance
1 Appearance albino
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Rb(6.15)1Ald
Symbol name Robertsonian translocation, Chr 6 and 15
Chromosome 15
Common name Rb1Ald
Symbol description No Data
2 Symbol Rb(6.15)1Ald
Symbol name Robertsonian translocation, Chr 6 and 15
Chromosome 6
Common name Rb1Ald
Symbol description No Data
References No Data

Research applications Genetics Research
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Shisa, Hayase (Saitama Cancer Center) Shisa, Hayase
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00222, SL/Kh

RBRC No. RBRC00222
Type Inbred
Species Mus musculus
Strain name SL/Kh
Former Common name No Data
H-2 Haplotype No Data
Background strain SL/KhStm
Appearance
1 Appearance albino
Genotype A/A, B/B, c/c
Strain development The spontaneous leukemia (SL) strain was originated from outbred Swiss albino mice, developed as a high-leukemia strain by Dr. K. Tsuchikawa in Mishima. At least 4 substrains, namely SL/Am, SL/Kh, SL/Ni, and SL/QDj had been established and maintained. SL/Kh and SL/Ni strains were deposited by Dr. Hayase Shisa, Saitama Cancer Center Institute. Pregnant females were transferred to RIKEN Tsukuba Institute, their babies were cleaned up by caesarean section, and introduced into the SPF facility.
Strain description SL/Kh is a member of the spontaneous leukemia family of mice, originated from outbred Swiss albino mice. Based on genotype analysis using microsatellite markers, SL/Kh was defined as a recombinant congenic strain between proto-SL and AKR strain mice. This strain develops pre-B lympomas by reintegration of the endogenous ecotropic MuLV provirus into a number of common integration sites, including Stat5a, Evi3, c-Myc, Stat5b, N-Myc, and others. SL/Kh is useful for an excellent multifactorial disease model.
Colony maintenance Sibling Mating
High incidence of pre-B lymphomas at early age
Health Report
Gene Details
Promoter No Data
1 Symbol Bomb1
Symbol name bone marrow pre-B 1
Chromosome 3
Common name No Data
Symbol description No Data
2 Symbol Tlsm1
Symbol name thymic lymphoma susceptible 1
Chromosome 7
Common name No Data
Symbol description No Data
References Cancer Res. 1994 Jan 15;54(2):399-402.
Cancer Res. 1994 Jan 15;54(2):403-7.
Cancer Res. 1996 Aug 15;56(16):3716-20.
Cancer Res. 1999 Jun 1;59(11):2593-5.
J Exp Med. 1994 Dec 1;180(6):2155-62.
J Natl Cancer Inst. 1987 Oct;79(4):781-7.
Lab Anim Sci. 1996 Aug;46(4):410-7.
Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8253-8. Epub 2002 Jun 4.

Research applications Cancer Research
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Shisa, Hayase (Saitama Cancer Center) Shisa, Hayase
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice. Proc. Natl. Acad. Sci. USA99: 8253-8258 (2002).(12048235)
Tatsuaki TSURUYAMA, Takuro NAKAMURA, Guang JIN, Munetaka OZEKI, Yoshihiro YAMADA, Hiroshi HIAI
Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Blood100: 238-245 (2002).(12070033)
Scott C KOGAN, Jerrold M WARD, Miriam R ANVER, Jules J BERMAN, Cory BRAYTON, Robert D CARDIFF, John S CARTER, Sherri de CORONADO, James R DOWNING, Torgny N FREDRICKSON, Diana C HAINES, Alan W HARRIS, Nancy Lee HARRIS, Hiroshi HIAI, Elaine S JAFFE, Ian C M MACLENNAN, Pier Paolo PANDOLFI, Paul K PATTENGALE, Archibald S PERKINS, R Mark SIMPSON, Mark S TUTTLE, Joanne F WONG, Herbert C 3rd MORSE
Svi3: A provirus common integration site in c-myc in SL/Kh pre-B lymphomas. Cancer Sci.94: 791-795 (2003).(12967477)
Guang JIN, Tatsuaki TSURUYAMA, Yoshihiro YAMADA, Hiroshi HIAI
Bone marrow pre-B expansion by SL/Kh-Bomb1 locus: not sufficient for lymphomagenesis. Leuk Res.32(2): 309-14 (2008).(17617450)
Hiratsuka T, Tsuruyama T, Kaszynski R, Kometani K, Minato N, Nakamura T, Tamaki K, Hiai H.
Genetic and virological predisposition to pre-B lymphomagenesis in SL/Kh. In: Mouse Models of Human Blood Cancers: Basic Research and Pre-Clinical Applications, ed. Li, S, Springer-Verlag. Springer-Verlag227-244 (2008).
Hiai H.
In vitro murine leukemia retroviral integration and structure fluctuation of target DNA. PLoS One.7(2): e31533 (2012).(22348097)
Tsuruyama T, Liu W, Yoshikawa K.
ZFP521 contributes to pre-B-cell lymphomagenesis through modulation of the pre-B-cell receptor signaling pathway. Oncogene (2015).(26522721)
Hiratsuka T, Takei Y, Ohmori R, Imai Y, Ozeki M, Tamaki K, Haga H, Nakamura T, Tsuruyama T.
STAT5A Modulates Chemokine Receptor CCR6 Expression and Enhances Pre-B Cell Growth in a CCL20-Dependent Manner. J. Cell Biochem. (2016).(27018255)
Tsuruyama T, Hiratsuka T, Wulamujiang A, Nakamura T.
DNA insertion mutations can be predicted by a periodic probability function. arXiv (2017).
Tatsuaki Tsuruyama.