RBRC01770, MSM/Ms-tyr c /Rin

RBRC No. RBRC01770
Type Wild-derived Inbred and Spontaneous Mutation
Species Mus musculus molossinus
Strain name MSM/Ms-tyrc/Rin
Former Common name No Data
H-2 Haplotype No Data
Background strain MSM [Mus musculus molossinus]
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Tyr
Symbol name tyrosinase
Chromosome 7
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 Organization HP
2 Genotyping protocol <PCR>
Depositor Yonekawa, Hiromichi (Tokyo Metropolitan Institute of Medical Science) Yonekawa, Hiromichi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Devising assisted reproductive technologies for wild-derived strains of mice: 37 strains from five subspecies of Mus musculus. PLoS One.9(12) e114305: e114305 (2014).(25470728)
Mochida K, Hasegawa A, Otaka N, Hama D, Furuya T, Yamaguchi M, Ichikawa E, Ijuin M, Taguma K, Hashimoto M, Takashima R, Kadota M, Hiraiwa N, Mekada K, Yoshiki A, Ogura A.

RBRC02250, C57BL/6J-Tg(CAG-Cox8/EGFP)49Rin

RBRC No. RBRC02250
Type TransgeneCartagena wks
Species Mus musculus
Strain name C57BL/6J-Tg(CAG-Cox8/EGFP)49Rin
Former Common name mtGFP-Tg
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Hiroshi Shitara and Hiromichi Yonekawa, Tokyo Metropolitan Institute of Medical Science in 2001. C57BL/6J background.
Strain description These transgenic express GFP in mitochondoria. This strain is useful for morphological analysis of mitochondoria in vivo. Tg hemizygous mice have a tendency to exhibit small body size, and females of hemizygote show lower reproductive performance. Homozygous mice are infertile.
Colony maintenance Carrier x Noncarrier [C57BL/6JJcl]
Health Report
Gene Details
Promoter No Data
1 Symbol GFP
Symbol name Green Fluorescent Protein (Jellyfish)
Chromosome UN
Common name No Data
Symbol description No Data
2 Symbol HBB2
Symbol name rabbit beta-globin polyA
Chromosome UN
Common name No Data
Symbol description No Data
3 Symbol MLS
Symbol name mitochondria localization signal (mouse cytochrome C)
Chromosome UN
Common name No Data
Symbol description No Data
Promoter CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)
4 Symbol Cox8a
Symbol name cytochrome c oxidase, subunit VIIIa
Chromosome UN
Common name COX VIII-L, COX8L
Symbol description No Data
References

Research applications Cell Biology Research,
Fluorescent Proteins/lacZ System
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
FEBS Letters, 500, 7-11 (2001). Exp. Anim., 59, 99-103 (2010).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 GFP Transfer License (Japanese / English)
Please fill in the Schedule A, and submit two signed copies to us together with two signed copies of RIKEN BRC’s MTA. Please also read Schedule B.
Organization HP
2 Genotyping protocol <PCR>
Depositor Yonekawa, Hiromichi (Tokyo Metropolitan Institute of Medical Science) Yonekawa, Hiromichi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Mitochondrial physiology and gene expression analyses reveal metabolic and translational dysregulation in oocyte-induced somatic nuclear reprogramming. PLoS One.7(6): e36850 (2012).(22693623)
Esteves TC, Psathaki OE, Pfeiffer MJ, Balbach ST, Zeuschner D, Shitara H, Yonekawa H, Siatkowski M, Fuellen G, Boiani M.

RBRC02570, C57BL/6JJcl-Adamts20<bt-Rin>

RBRC No. RBRC02570
Type Transgene and Spontaneous MutationCartagena wks
Species Mus musculus
Strain name C57BL/6JJcl-Adamts20<bt-Rin>
Former Common name belt
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Adamts20
Symbol name a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20
Chromosome 15
Common name ADAMTS-20, bt
Symbol description No Data
References J. Hered., 36, 266-268 (1945).

Research applications No Data
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 Organization HP
2 Genotyping protocol <PCR>
Depositor Yonekawa, Hiromichi (Tokyo Metropolitan Institute of Medical Science) Yonekawa, Hiromichi
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC02767, C57BL/6J-Tg(InsBAC-TRECK/DTR)5Rin

RBRC No. RBRC02767
Type TransgeneCartagena
Species Mus musculus
Strain name C57BL/6J-Tg(InsBAC-TRECK/DTR)5Rin
Former Common name No Data
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Kunie Matsuoka and Hiromichi Yonekawa, Tokyo Metropolitan Institute of Medical Science. The transgene was injected into the pronuclei of C57BL/6J fertilized eggs. RBRC02767 (line 5), RBRC02768 (line 14), RBRC02769 (line 17), RBRC02770 (line 33), RBRC02771 (scid background, the same line as the #70 in BBRC2013 article).
Strain description INS2(BAC)-TRECK transgenic mice, expressing hDTR cDNA under the control of the mouse insulin II promoter. Hyperglycemia, severe ablation of pancreatic beta cells and depletion of serum insulin were observed within 3 days after the administration of DT.
Health Report
Gene Details
Promoter mouse Ins2 promoter
1 Symbol HBEGF
Symbol name heparin-binding EGF-like growth factor (human)
Chromosome UN
Common name No Data
Symbol description No Data
References

Research applications Diabetes and Obesity Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Biochem. Biophys. Res. Commun., 436, 400-405 (2013).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. The RECIPIENT of BIOLOGICAL RESOURCE, who belongs to a profit organization must obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 Organization HP
Depositor Yonekawa, Hiromichi (Tokyo Metropolitan Institute of Medical Science) Yonekawa, Hiromichi
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC02768, C57BL/6J-Tg(InsBAC-TRECK/DTR)14Rin

RBRC No. RBRC02768
Type TransgeneCartagena
Species Mus musculus
Strain name C57BL/6J-Tg(InsBAC-TRECK/DTR)14Rin
Former Common name No Data
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Kunie Matsuoka and Hiromichi Yonekawa, Tokyo Metropolitan Institute of Medical Science. The transgene was injected into the pronuclei of C57BL/6J fertilized eggs. RBRC02767 (line 5), RBRC02768 (line 14), RBRC02769 (line 17), RBRC02770 (line 33), RBRC02771 (scid background, the same line as the #70 in BBRC2013 article).
Strain description INS2(BAC)-TRECK transgenic mice, expressing hDTR cDNA under the control of the mouse insulin II promoter. Hyperglycemia, severe ablation of pancreatic beta cells and depletion of serum insulin were observed within 3 days after the administration of DT.
Health Report No Data
Gene Details
Promoter mouse Ins2 promoter
1 Symbol HBEGF
Symbol name heparin-binding EGF-like growth factor (human)
Chromosome UN
Common name No Data
Symbol description No Data
References

Research applications Diabetes and Obesity Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Biochem. Biophys. Res. Commun., 436, 400-405 (2013).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. The RECIPIENT of BIOLOGICAL RESOURCE, who belongs to a profit organization must obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 Organization HP
Depositor Yonekawa, Hiromichi (Tokyo Metropolitan Institute of Medical Science) Yonekawa, Hiromichi
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02769, C57BL/6J-Tg(InsBAC-TRECK/DTR)17Rin

RBRC No. RBRC02769
Type TransgeneCartagena
Species Mus musculus
Strain name C57BL/6J-Tg(InsBAC-TRECK/DTR)17Rin
Former Common name No Data
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Kunie Matsuoka and Hiromichi Yonekawa, Tokyo Metropolitan Institute of Medical Science. The transgene was injected into the pronuclei of C57BL/6J fertilized eggs. RBRC02767 (line 5), RBRC02768 (line 14), RBRC02769 (line 17), RBRC02770 (line 33), RBRC02771 (scid background, the same line as the #70 in BBRC2013 article).
Strain description INS2(BAC)-TRECK transgenic mice, expressing hDTR cDNA under the control of the mouse insulin II promoter. Hyperglycemia, severe ablation of pancreatic beta cells and depletion of serum insulin were observed within 3 days after the administration of DT.
Health Report No Data
Gene Details
Promoter mouse Ins2 promoter
1 Symbol HBEGF
Symbol name heparin-binding EGF-like growth factor (human)
Chromosome UN
Common name No Data
Symbol description No Data
References

Research applications Diabetes and Obesity Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Biochem. Biophys. Res. Commun., 436, 400-405 (2013).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. The RECIPIENT of BIOLOGICAL RESOURCE, who belongs to a profit organization must obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 Organization HP
Depositor Yonekawa, Hiromichi (Tokyo Metropolitan Institute of Medical Science) Yonekawa, Hiromichi
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02770, C57BL/6J-Tg(InsBAC-TRECK/DTR)33Rin

RBRC No. RBRC02770
Type TransgeneCartagena
Species Mus musculus
Strain name C57BL/6J-Tg(InsBAC-TRECK/DTR)33Rin
Former Common name No Data
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Kunie Matsuoka and Hiromichi Yonekawa, Tokyo Metropolitan Institute of Medical Science. The transgene was injected into the pronuclei of C57BL/6J fertilized eggs. RBRC02767 (line 5), RBRC02768 (line 14), RBRC02769 (line 17), RBRC02770 (line 33), RBRC02771 (scid background, the same line as the #70 in BBRC2013 article).
Strain description INS2(BAC)-TRECK transgenic mice, expressing hDTR cDNA under the control of the mouse insulin II promoter. Hyperglycemia, severe ablation of pancreatic beta cells and depletion of serum insulin were observed within 3 days after the administration of DT.
Health Report No Data
Gene Details
Promoter mouse Ins2 promoter
1 Symbol HBEGF
Symbol name heparin-binding EGF-like growth factor (human)
Chromosome UN
Common name No Data
Symbol description No Data
References

Research applications Diabetes and Obesity Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Biochem. Biophys. Res. Commun., 436, 400-405 (2013).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. The RECIPIENT of BIOLOGICAL RESOURCE, who belongs to a profit organization must obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 Organization HP
Depositor Yonekawa, Hiromichi (Tokyo Metropolitan Institute of Medical Science) Yonekawa, Hiromichi
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02771, C.B-17/Icr Prkdc<scid>-Tg(INS-TRECK/DTR)1Rin

RBRC No. RBRC02771
Type TransgeneCartagena
Species Mus musculus
Strain name C.B-17/Icr Prkdc<scid>-Tg(INS-TRECK/DTR)1Rin
Former Common name BALB/c Prkdc-Tg(INS-TRECK/DTR)1Rin
H-2 Haplotype No Data
Background strain C.B-17/Icr-scid/Jcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Kunie Matsuoka and Hiromichi Yonekawa, Tokyo Metropolitan Institute of Medical Science. The transgene was injected into the pronuclei of C.B-17/Icr-scid fertilized eggs. RBRC02767 (line 5), RBRC02768 (line 14), RBRC02769 (line 17), RBRC02770 (line 33), RBRC02771 ((scid background, the same line as the #70 in BBRC2013 article).
Strain description scid-INS-TRECK Transgenic mice, having the diphtheria toxin receptor (hDTR) driven by the human insulin promoter and Prkdc<scid> mutation. Hyperglycemia was observed within 3 days after the administration of DT.
Health Report
BRC facility Health Report in the last year and a half

Examination Date Room Rack
Mar 7, 2016 2-検 F
Nov 9, 2015 2-検 G
Sep 7, 2015 2-検 G
Jul 6, 2015 2-検 G
May 11, 2015 2-検 G
Mar 9, 2015 2-検 G
Jan 13, 2015 2-検 G
Nov 10, 2014 2-検 G

Gene Details
Promoter No Data
1 Symbol Prkdc
Symbol name protein kinase, DNA activated, catalytic polypeptide
Chromosome 16
Common name No Data
Symbol description No Data
Promoter human Insulin promoter
2 Symbol HBEGF
Symbol name heparin-binding EGF-like growth factor (human)
Chromosome UN
Common name No Data
Symbol description No Data
References

Research applications Diabetes and Obesity Research,
Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Biochem. Biophys. Res. Commun., 436, 400-405 (2013).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. The RECIPIENT of BIOLOGICAL RESOURCE, who belongs to a profit organization must obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 Organization HP
2 Genotyping protocol <PCR>
Depositor Yonekawa, Hiromichi (Tokyo Metropolitan Institute of Medical Science) Yonekawa, Hiromichi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC04191, C57BL/6J-Tg(Gsl5BAC-EGFP)14Rin

RBRC No. RBRC04191
Type TransgeneCartagena
Species Mus musculus
Strain name C57BL/6J-Tg(Gsl5BAC-EGFP)14Rin
Former Common name Gsl5-recombinantBAC-EGFP transgenic mouse
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter mouse Gsl5 (kidney proximal tubule-specific promoter)
1 Symbol GFP
Symbol name Green Fluorescent Protein (Jellyfish)
Chromosome UN
Common name No Data
Symbol description No Data
References J Biol Chem. 2006 Jan 13;281(2):1008-15. Epub 2005 Nov 8.

The cis-regulatory element Gsl5 is indispensable for proximal straight tubule cell-specific transcription of core 2 beta-1,6-N-acetylglucosaminyltransferase in the mouse kidney.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from DEPOSITOR using the Approval Form.
Additional information
1 GFP Transfer License (Japanese / English)
Please fill in the Schedule A, and submit two signed copies to us together with two signed copies of RIKEN BRC’s MTA. Please also read Schedule B.
Organization HP
Depositor Yonekawa, Hiromichi (Tokyo Metropolitan Institute of Medical Science) Yonekawa, Hiromichi
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC04192, C57BL/6J-Tg(Gsl5BAC-EGFP)27Rin

RBRC No. RBRC04192
Type TransgeneCartagena
Species Mus musculus
Strain name C57BL/6J-Tg(Gsl5BAC-EGFP)27Rin
Former Common name Gsl5-recombinantBAC-EGFP transgenic mouse
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter mouse Gsl5 (kidney proximal tubule-specific promoter)
1 Symbol GFP
Symbol name Green Fluorescent Protein (Jellyfish)
Chromosome UN
Common name No Data
Symbol description No Data
References J Biol Chem. 2006 Jan 13;281(2):1008-15. Epub 2005 Nov 8.

The cis-regulatory element Gsl5 is indispensable for proximal straight tubule cell-specific transcription of core 2 beta-1,6-N-acetylglucosaminyltransferase in the mouse kidney.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from DEPOSITOR using the Approval Form.
Additional information
1 GFP Transfer License (Japanese / English)
Please fill in the Schedule A, and submit two signed copies to us together with two signed copies of RIKEN BRC’s MTA. Please also read Schedule B.
Organization HP
Depositor Yonekawa, Hiromichi (Tokyo Metropolitan Institute of Medical Science) Yonekawa, Hiromichi
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months