RBRC03552, B6.129-Abcd1<tm1Ymd>

RBRC No. RBRC03552
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129-Abcd1<tm1Ymd>
Former Common name No Data
H-2 Haplotype No Data
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Abcd1
Symbol name ATP-binding cassette, sub-family D (ALD), member 1
Chromosome X
Common name No Data
Symbol description No Data
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome X
Common name No Data
Symbol description No Data
References

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Biochem Biophys Res Commun, 232, 631-636 (1997).
Additional information
1 No Data
Depositor Hashimoto, Naohiro (National Institute for Longevity Sciences) Hashimoto, Naohiro
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC03556, B6.129-Dmd<tm1Mok>

RBRC No. RBRC03556
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129-Dmd<tm1Mok>
Former Common name Mdx52, B6-Dmd KO
H-2 Haplotype No Data
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Motoya Katsuki, Institute of Medical Science, University of Tokyo. CCE/EK.CCE ES cells were used. The mutant mice were backcrossed to C57BL/6 by Naohiro Hashimoto, National Center for Geriatrics and Gerontology.
Strain description dystrophin (Dmd) gene knockout mice. The exon 52 was replaced with a neo cassette. Mutant mice show hypertrophic skeletal muscles. Homozygous female and hemizygous male mutants are viable and fertile. The mice are difficult to start breeding at 8-10 weeks (12-16 weeks is better).
Colony maintenance Homozygote (female) x Hemizygote (male) [or Crossing to C57BL/6JJcl]
Health Report
Gene Details
Promoter No Data
1 Symbol Dmd
Symbol name dystrophin, muscular dystrophy
Chromosome X
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
2 Symbol neo
Symbol name neomycin resistance gene (Klebsiella pneumoniae)
Chromosome X
Common name No Data
Symbol description No Data
References Biochem Biophys Res Commun. 1997 Sep 18;238(2):492-7.

Targeted disruption of exon 52 in the mouse dystrophin gene induced muscle degeneration similar to that observed in Duchenne muscular dystrophy.
Research applications Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Biochem. Biophys. Res. Commun., 238, 492-497 (1997).
Additional information
1 Mouse of the Month Apr 2014
2 Genotyping protocol <PCR>
Depositor Hashimoto, Naohiro (National Institute for Longevity Sciences) Hashimoto, Naohiro
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC03557, B6C3.129P2-Myog<tm1Yin>

RBRC No. RBRC03557
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6C3.129P2-Myog<tm1Yin>
Former Common name Myog KO
H-2 Haplotype No Data
ES cell line E14 [129P2/OlaHsd]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Yo-ichi Nabeshima, National Institute of Neuroscience. E14 ES cells were used. C57BL/6 and C3H mixed background.
Strain description Myog (myogenin gene knockout mice. Homozygous mutant mice are embryonic lethal.
Colony maintenance Heterozygote x Wild-type [or Crossing to Jcl:B6C3F1]
Health Report
Gene Details
Promoter No Data
1 Symbol Myog
Symbol name myogenin
Chromosome 1
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 1
Common name No Data
Symbol description No Data
References

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Nature, 364, 643, 532-535 (1993).
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Hashimoto, Naohiro (National Institute for Longevity Sciences) Hashimoto, Naohiro
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC03558, 129.Cg-Pax7<tm1Pgr>

RBRC No. RBRC03558
Type Targeted MutationCartagena
Species Mus musculus
Strain name 129.Cg-Pax7<tm1Pgr>
Former Common name Pax129, 129-Pax7 KO
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Peter Gruss, Max Planck Institute for Biophysical Chemistry. The mutant mice were backcrossed 129 over 20 times by Naohiro Hashimoto, National Center for Geriatrics and Gerontology.
Strain description Pax7 gene knockout mice. The first exon of the paired box was replaced with a neo cassette (RBRC03558) and lacZ-neo cassette (RBRC03559), respectively. In the C57BL/6 background, most homozygous mutant mice die within 3 weeks after birth (survival rate is below 10%). On the other hand, in the 129 background (RBRC03558 and RBRC03559), approximately 50% of mutant mice die within 3 weeks after birth (details unknown). Heterozygous mutant mice for lacZ repoter Pax7<tm2Pgr> (RBRC03559) show negative X-gal staining in the muscle satellite cells.
Colony maintenance Heterozygote x Wild-type [or Crossing to 129<+Ter>/SvJcl]
Health Report
Gene Details
Promoter No Data
1 Symbol Pax7
Symbol name paired box gene 7
Chromosome 4
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (Klebsiella pneumoniae)
Chromosome 4
Common name No Data
Symbol description No Data
References

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEVELOPER of the Pax7tm1Pgr allele (Peter Gruss, Max Planck Institute for Biophysical Chemistry). (http://www.mpibpc.mpg.de/de/gruss)
Additional information
1 MATERIAL TRANSFER AGREEMENT (English)
2 Genotyping protocol <PCR>
Depositor Hashimoto, Naohiro (National Institute for Longevity Sciences) Hashimoto, Naohiro
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

Live
Live mouse :

RBRC03559, 129.Cg-Pax7<tm2Pgr>

RBRC No. RBRC03559
Type Targeted MutationCartagena
Species Mus musculus
Strain name 129.Cg-Pax7<tm2Pgr>
Former Common name PaxZ129, 129-Pax7/lacZ
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Peter Gruss, Max Planck Institute for Biophysical Chemistry. The mutant mice were backcrossed 129 over 20 times by Naohiro Hashimoto, National Center for Geriatrics and Gerontology.
Strain description Pax7 gene knockout mice. The first exon of the paired box was replaced with a neo cassette (RBRC03558) and lacZ-neo cassette (RBRC03559), respectively. In the C57BL/6 background, most homozygous mutant mice die within 3 weeks after birth (survival rate is below 10%). On the other hand, in the 129 background (RBRC03558 and RBRC03559), approximately 50% of mutant mice die within 3 weeks after birth (details unknown). Heterozygous mutant mice for lacZ repoter Pax7<tm2Pgr> (RBRC03559) show negative X-gal staining in the muscle satellite cells.
Colony maintenance Heterozygote x Wild-type [or Crossing to 129<+Ter>/SvJcl]
Health Report
Gene Details
Promoter No Data
1 Symbol Pax7
Symbol name paired box gene 7
Chromosome 4
Common name No Data
Symbol description No Data
2 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 4
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
3 Symbol neo
Symbol name neomycin resistance gene (Klebsiella pneumoniae)
Chromosome 4
Common name No Data
Symbol description No Data
References

Research applications Fluorescent Proteins/lacZ System
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEVELOPER of the Pax7tm2Pgr allele (Peter Gruss, Max Planck Institute for Biophysical Chemistry). (http://www.mpibpc.mpg.de/de/gruss)
Additional information
1 MATERIAL TRANSFER AGREEMENT (English)
2 Genotyping protocol <PCR>
Depositor Hashimoto, Naohiro (National Institute for Longevity Sciences) Hashimoto, Naohiro
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC06190, D2;129-Myod1<tm1Jae>

RBRC No. RBRC06190
Type Targeted MutationCartagena
Species Mus musculus
Strain name D2;129-Myod1<tm1Jae>
Former Common name MyoD-KO, D2-Myod1 KO
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Rudolf Jaenisch, Whitehead Institute and Department of Biology Massachusetts Institute of Technology Cambridge. J1 ES cells were used. The mutant mice were maintained by Naohiro Hashimoto, National Center for Geriatrics and Gerontology. 129 and DBA/2 mixed background.
Strain description MyoD1 gene knockout mice. The Myod1 promoter, exon 1 and half of intron 1 were replaced with a a neomycin cassette.
Colony maintenance Homozygote x Homozygote
Health Report
Gene Details
Promoter No Data
1 Symbol Myod1
Symbol name myogenic differentiation 1
Chromosome 7
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (Klebsiella pneumoniae)
Chromosome 7
Common name No Data
Symbol description No Data
References

Research applications Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Cell, 71, 383-390 (1992).
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Hashimoto, Naohiro (National Institute for Longevity Sciences) Hashimoto, Naohiro
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC06191, B6.129-Acsbg1<tm1Nah>

RBRC No. RBRC06191
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129-Acsbg1<tm1Nah>
Former Common name Lipidosin-KO, B6-Acsbg1 KO
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Naohiro Hashimoto, National Center for Geriatrics and Gerontology in 2004. The mutant mice were backcrossed to C57BL/6.
Strain description Lipidosin (Acsbg1) gene knockout mice. Homozygous mutant mice show no obvious abnormality.
Colony maintenance Homozygote x Homozygote [or Crossing to C57BL/6JJcl]
Health Report
Gene Details
Promoter No Data
1 Symbol Acsbg1
Symbol name acyl-CoA synthetase bubblegum family member 1
Chromosome 9
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (Klebsiella pneumoniae)
Chromosome 9
Common name No Data
Symbol description No Data
References

Research applications No Data
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Hashimoto, Naohiro (National Institute for Longevity Sciences) Hashimoto, Naohiro
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC06192, B6.129-Trib3<tm1Nah>

RBRC No. RBRC06192
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129-Trib3<tm1Nah>
Former Common name Nudin1-KO, B6-Trib3 KO
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Naohiro Hashimoto, National Center for Geriatrics and Gerontology in 2004. The mutant mice were backcrossed to C57BL/6.
Strain description Nudin1 (Trib3) gene knockout mice. Homozygous mutant mice show no obvious abnormality.
Colony maintenance Homozygote x Homozygote [or Crossing to C57BL/6JJcl]
Health Report
Gene Details
Promoter No Data
1 Symbol Trib3
Symbol name ribbles homolog 3 (Drosophila)
Chromosome 2
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (Klebsiella pneumoniae)
Chromosome 2
Common name No Data
Symbol description No Data
References

Research applications Diabetes and Obesity Research
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Hashimoto, Naohiro (National Institute for Longevity Sciences) Hashimoto, Naohiro
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC06193, B6.Cg-Tg(Pax7-eGFP)13Nah

RBRC No. RBRC06193
Type TransgeneCartagena
Species Mus musculus
Strain name B6.Cg-Tg(Pax7-eGFP)13Nah
Former Common name PaxG13, B6-Pax7-eGFP Tg#13
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Naohiro Hashimoto, National Center for Geriatrics and Gerontology in 2004. The mutant mice were backcrossed to C57BL/6.
Strain description Pax7-GFP BAC transgenic mice. The GFP cDNA was inserted into the exon 1 of Pax7 BAC gene. Expresion of the transgene mostly matches that of the endogenous Pax7 in the nervous system, but, limited to part of anti-Pax7 positive cells in the muscle satellite cells.
Colony maintenance Carrier x Noncarrier [C57BL/6JJcl]
Health Report
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name SV40 polyA signal
Chromosome UN
Common name No Data
Symbol description No Data
2 Symbol Cm
Symbol name Chloramphenicol resistantce gene (E. coli)
Chromosome UN
Common name No Data
Symbol description No Data
Promoter mouse Pax7 promoter
3 Symbol EGFP
Symbol name Enhanced Green Fluorescent Protein, F64L and S65T (Jellyfish)
Chromosome UN
Common name No Data
Symbol description No Data
References Unpublished

Research applications Fluorescent Proteins/lacZ System
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 GFP Transfer License (Japanese / English)
Please fill in the Schedule A, and submit two signed copies to us together with two signed copies of RIKEN BRC’s MTA. Please also read Schedule B.
2 Genotyping protocol <PCR>
Depositor Hashimoto, Naohiro (National Institute for Longevity Sciences) Hashimoto, Naohiro
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC03551, B6.Cg-Abcd1<tm1Ymd>

RBRC No. RBRC03551
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.Cg-Abcd1<tm1Ymd>
Former Common name No Data
H-2 Haplotype No Data
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Abcd1
Symbol name ATP-binding cassette, sub-family D (ALD), member 1
Chromosome X
Common name No Data
Symbol description No Data
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome X
Common name No Data
Symbol description No Data
References

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Biochem Biophys Res Commun, 232, 631-636 (1997).
Additional information
1 No Data
Depositor Hashimoto, Naohiro (National Institute for Longevity Sciences) Hashimoto, Naohiro
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months