RBRC00923, GATA-1 promoter-LacZ mice IE3.9LacZ 404 line

RBRC No. RBRC00923
Type TransgeneCartagena
Species Mus musculus
Strain name GATA-1 promoter-LacZ mice IE3.9LacZ 404 line
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter mouse GATA-1 promoter
1 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome UN
Common name No Data
Symbol description E. coli beta galactosidase
References Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4487-92.

GATA-1 transcription is controlled by distinct regulatory mechanisms during primitive and definitive erythropoiesis.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Proc. Natl. Acad. Sci. U.S.A. 94, 4487-4492 (1997).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The depositor should be a co-author in articles when the users publish their data using these mice for 2 year after provided. Users should contact the depositor in the case of application for any patents with the results from these mice.
Additional information
1 Lab HP (Japanese)
Depositor Yamamoto, Masayuki (University of tsukuba) Yamamoto, Masayuki
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00940, GATA-1 promoter-LacZ mice ITdUE IEintLacZ 863-188 line

RBRC No. RBRC00940
Type TransgeneCartagena
Species Mus musculus
Strain name GATA-1 promoter-LacZ mice ITdUE IEintLacZ 863-188 line
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter mouse GATA-1 promoter
1 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome UN
Common name No Data
Symbol description E. coli beta galactosidase
References Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4487-92.

GATA-1 transcription is controlled by distinct regulatory mechanisms during primitive and definitive erythropoiesis.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The depositor should be a co-author in articles when the users publish their data using these mice for 2 year after provided. Users should contact the depositor in the case of application for any patents with the results from these mice.
Additional information
1 Lab HP (Japanese)
Depositor Yamamoto, Masayuki (University of tsukuba) Yamamoto, Masayuki
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC01663, B6D2-Tg(hK14-AhR-CA)239Mym/MymRbrc

RBRC No. RBRC01663
Type Transgene CongenicCartagena wks
Species Mus musculus
Strain name B6D2-Tg(hK14-AhR-CA)239Mym/MymRbrc
Former Common name K14-AhR-CA TG mouse line 239
H-2 Haplotype No Data
Background strain Jcl:B6D2F1
Appearance
1 Appearance black
Genotype a/a B/? C/C D/?
2 Appearance brown
Genotype a/a b/b C/C D/D
3 Appearance dilute brown
Genotype a/a b/b C/C d/d
4 Appearance dilute black
Genotype a/a B/? C/C d/d
Strain development Developed by Dr. Masayuki Yamamoto at Tsukuba University in 2002. A cDNA fragment encording the constitutive active form of mouse AhR (AhR-CA) under the human cytokeratin 14 promoter was injected into the pronuclei of fertilized egges of B6D2F1.
Strain description K14-AhR-CA transgenic mice carry a cDNA fragment encording the constitutive active form of mouse AhR (aryl hydrocarbon receptor) under control of human cytokeratin 14 promoter. The aryl hydrocarbon receptor (AhR) (dioxin receptor) is a transcription factor that mediate to catalyze xenobiotic Phase I metabolism. Tg hemizygote mice are normal at birth, but severe skin lesions with itching develop postnatally. This strain is useful for the evaluation of the causal relationship between the AhR gene expression and inflammatory dermatitis.
Colony maintenance Cross to B6D2F1 (Hemizygous x Jcl:B6D2F1)
Tg hemizygote mice are normal at birth, but severe skin lesions with itching develop postnatally.
Health Report
BRC facility Health Report in the last year and a half

Examination Date Room Rack
May 7, 2012 2-検 A
Mar 5, 2012 2-検 A
Jan 10, 2012 2-検 A
Nov 7, 2011 2-検 A
Sep 5, 2011 2-検 A
Jul 4, 2011 2-検 A
Apr 25, 2011 2-検 A
Mar 7, 2011 2-検 A

Gene Details
Promoter No Data
1 Symbol HA
Symbol name human influenza virus HA (hemagglutinin) tag sequence
Chromosome No Data
Common name No Data
Symbol description No Data
2 Symbol poly A
Symbol name poly A
Chromosome No Data
Common name No Data
Symbol description No Data
Promoter human Keratin14 promoter
3 Symbol Ahr
Symbol name aryl-hydrocarbon receptor
Chromosome UN
Common name Ah, Ahh, Ahre, dioxin receptor, In
Symbol description No Data
References Mol Cell Biol. 2005 Nov;25(21):9360-8.

Constitutive expression of aryl hydrocarbon receptor in keratinocytes causes inflammatory skin lesions.
Research applications Dermatology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Mol. Cell. Biol., 25, 9360-9368 (2005).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT agrees to include the DEPOSITOR/DEVELOPER as a co-author in any publications resulted by the use of the BIOLOGICAL RESOURCE during the first 2 years after deposition by the DEPOSITOR to the RIKEN BRC. The RECIPIENT should contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 Lab HP (Japanese)
2 Mouse of the Month Aug 2007
3 Genotyping protocol <PCR>
Depositor Yamamoto, Masayuki (University of tsukuba) Yamamoto, Masayuki
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC10148, B6.129-Nfe2l1<tm1.2Mym>

RBRC No. RBRC10148
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129-Nfe2l1<tm1.2Mym>
Former Common name Nrf1-floxed mouse
H-2 Haplotype No Data
ES cell line E14 [129P2/OlaHsd]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol EGFP
Symbol name Enhanced Green Fluorescent Protein, F64L and S65T (Jellyfish)
Chromosome 11
Common name No Data
Symbol description No Data
2 Symbol Ires
Symbol name internal ribosomal entry site (EMCV)
Chromosome 11
Common name No Data
Symbol description No Data
3 Symbol Nfe2l1
Symbol name nuclear factor, erythroid derived 2,-like 1
Chromosome 11
Common name No Data
Symbol description No Data
4 Symbol loxP
Symbol name phage P1 loxP
Chromosome 11
Common name No Data
Symbol description No Data
5 Symbol loxP
Symbol name phage P1 loxP
Chromosome 11
Common name No Data
Symbol description No Data
References No Data

Research applications Cre/loxP system,
Fluorescent Proteins/lacZ System
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Biol. Chem., 283, 33554-33562 (2008).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
For two years after deposition, the RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 GFP Transfer License (Japanese / English)
Please fill in the Schedule A, and submit two signed copies to us together with two signed copies of RIKEN BRC’s MTA. Please also read Schedule B.
2 Genotyping protocol <PCR>
Depositor Yamamoto, Masayuki (Tohoku university) Yamamoto, Masayuki
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC00924, GATA-1 promoter-LacZ mice IE3.9LacZ 932 line

RBRC No. RBRC00924
Type TransgeneCartagena
Species Mus musculus
Strain name GATA-1 promoter-LacZ mice IE3.9LacZ 932 line
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter mouse GATA-1 promoter
1 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome UN
Common name No Data
Symbol description E. coli beta galactosidase
References Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4487-92.

GATA-1 transcription is controlled by distinct regulatory mechanisms during primitive and definitive erythropoiesis.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Proc. Natl. Acad. Sci. U.S.A. 94, 4487-4492 (1997).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The depositor should be a co-author in articles when the users publish their data using these mice for 2 year after provided. Users should contact the depositor in the case of application for any patents with the results from these mice.
Additional information
1 Lab HP (Japanese)
Depositor Yamamoto, Masayuki (University of tsukuba) Yamamoto, Masayuki
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00941, GATA-1 promoter-LacZ mice ITintdUEntLacZ 863-978 line

RBRC No. RBRC00941
Type TransgeneCartagena
Species Mus musculus
Strain name GATA-1 promoter-LacZ mice ITintdUEntLacZ 863-978 line
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter mouse GATA-1 promoter
1 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome UN
Common name No Data
Symbol description E. coli beta galactosidase
References Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4487-92.

GATA-1 transcription is controlled by distinct regulatory mechanisms during primitive and definitive erythropoiesis.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The depositor should be a co-author in articles when the users publish their data using these mice for 2 year after provided. Users should contact the depositor in the case of application for any patents with the results from these mice.
Additional information
1 Lab HP (Japanese)
Depositor Yamamoto, Masayuki (University of tsukuba) Yamamoto, Masayuki
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02190, C.129P2-Nfe2l2<tm1Mym>

RBRC No. RBRC02190
Type Targeted Mutation CongenicCartagena wks
Species Mus musculus
Strain name C.129P2-Nfe2l2<tm1Mym>
Former Common name BALB/c(F10)-nfe2l2
H-2 Haplotype No Data
Background strain BALB/cAJcl
Appearance
1 Appearance albino
Genotype A/A b/b c/c
Strain development Developed by Masayuki Yamamoto, Institute of Basic Medical Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba in 1996. The targeting vector containing lacZ-neo cassette was transferred into E14 ES cells to replace the 1.2 kb segment containing the rest of the exon 5 coding sequence of the Nrf2 gene.
Strain description Nrf2 (Nfe2l2) Knockout mice. This strain is a useful model for the in vivo analysis of chemical carcinogenesis and resistance to anti-cancer drugs. A phenolic antioxidant significantly induced the expression of phase II enzymes such as glutathione S-transferase and NAD(P)H: quinone oxidoreductase in normal mice. However, in the homozygous Nrf2 deficient mice the induction of the phase II enzymes by a phenolic antioxidant was largely eliminated in the liver and intestine. Since Nrf2 is constantly degraded by proteasome under normal condition, it is hardly to detect Nrf2 protein in the absence of stimuli. Electrophilic chemicals, such as DEM (diethyl maleate) and tBHQ (tert-buthyl hydroquinone), are generally used to stabilize Nrf2. Or proteasomal inhibitors, such as MG132, are also effective increasing the protein amount of Nrf2. C57BL/6 background (RBRC01390), BALB/c background (RBRC02190), A/J background (RBRC02414), ICR mixed background (RBRC00984). Homozygous mutant mice are viable and fertile, but show lower reproductive performance.
Colony maintenance Homozygote x Heterozygote [or Crossing to BALB/cAJcl]
Health Report
Gene Details
Promoter No Data
1 Symbol Nfe2l2
Symbol name nuclear factor, erythroid derived 2, like 2
Chromosome 2
Common name Nrf2
Symbol description No Data
2 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 2
Common name No Data
Symbol description E. coli beta galactosidase
3 Symbol nls
Symbol name SV40 large T antigen nuclear localization signal (NLS)
Chromosome 2
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
4 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 2
Common name neo; neomycin;
Symbol description No Data
References Biochem Biophys Res Commun. 1997 Jul 18;236(2):313-22.

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Biochem. Biophys. Res. Commun. 236,313-322 (1997).
The DEPOSITEOR should be a co-author in the articles when the RECIPIENT publish their data using these mice for 2 year after deposition to the RIKEN BRC. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from these mice.
Additional information
1 Lab HP (Japanese)
2 Mouse of the Month Apr 2012
3 Genotyping protocol <PCR>
Depositor Yamamoto, Masayuki (University of tsukuba) Yamamoto, Masayuki
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC10149, B6.B6D2-Tg(Mafg-Nfe2l1)1Mym

RBRC No. RBRC10149
Type TransgeneCartagena
Species Mus musculus
Strain name B6.B6D2-Tg(Mafg-Nfe2l1)1Mym
Former Common name MGRD-Nrf1-Tg mouse
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name mouse Mafg pA and 3′ region
Chromosome UN
Common name No Data
Symbol description No Data
2 Symbol FLAG
Symbol name No Data
Chromosome UN
Common name No Data
Symbol description No Data
Promoter mouse Mafg promoter
3 Symbol Nfe2l1
Symbol name nuclear factor, erythroid derived 2,-like 1
Chromosome UN
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Genes Cells. 19, 650-665 (2014).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
For two years after deposition, the RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Yamamoto, Masayuki (Tohoku university) Yamamoto, Masayuki
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC00925, GATA-1 promoter-LacZ mice ITint8.0LacZ 0 line

RBRC No. RBRC00925
Type TransgeneCartagena
Species Mus musculus
Strain name GATA-1 promoter-LacZ mice ITint8.0LacZ 0 line
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter mouse GATA-1 promoter
1 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome UN
Common name No Data
Symbol description E. coli beta galactosidase
References Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4487-92.

GATA-1 transcription is controlled by distinct regulatory mechanisms during primitive and definitive erythropoiesis.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The depositor should be a co-author in articles when the users publish their data using these mice for 2 year after provided. Users should contact the depositor in the case of application for any patents with the results from these mice.
Additional information
1 Lab HP (Japanese)
Depositor Yamamoto, Masayuki (University of tsukuba) Yamamoto, Masayuki
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00942, GATA-1 promoter-LacZ mice ITintApaintLacZ 364 line

RBRC No. RBRC00942
Type TransgeneCartagena
Species Mus musculus
Strain name GATA-1 promoter-LacZ mice ITintApaintLacZ 364 line
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter mouse GATA-1 promoter
1 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome UN
Common name No Data
Symbol description E. coli beta galactosidase
References Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4487-92.

GATA-1 transcription is controlled by distinct regulatory mechanisms during primitive and definitive erythropoiesis.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The depositor should be a co-author in articles when the users publish their data using these mice for 2 year after provided. Users should contact the depositor in the case of application for any patents with the results from these mice.
Additional information
1 Lab HP (Japanese)
Depositor Yamamoto, Masayuki (University of tsukuba) Yamamoto, Masayuki
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months