RBRC01253, B6;129S4-Gopc<tm1.1Tno>/Rbrc

RBRC No. RBRC01253
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129S4-Gopc<tm1.1Tno>/Rbrc
Former Common name GOPC Knockout mouse
H-2 Haplotype No Data
Donor strain 129S4/SvJae via J1 ES cell line
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Drs. Ryoji Yao and Tetsuo Noda, Japanese Foundation for Cancer Research Cancer Institute in 1999. Genomic sequence containing 2, 2b, 3 and 4 of Gopc was replaced by the insertion of a LacZ and a floxed neo cassette. The floxed neo cassette was excised in this strain. This strain originated on a B6;129 bachground.
Strain description B6;129S4-Gopc<tm1.1Tno>. Gopc, golgi associtated PDZ and coiled-coil motif containing that predominantly localized at trans-Golgi region, propose that play a role in vesicle transport from the Golgi. The Gopc deficient male mice are infertile that spermatozoa showed complete lack of acrosomes. This knockout mice are proved to be powerful tools for understanding the mechanisms underlying spermatogenesism, and valuable animal mode for human globozoospermia.
Colony maintenance Sibling Mating (Heterozygote x Wild-type, Heterozygote)
Health Report
Gene Details
Promoter No Data
1 Symbol Gopc
Symbol name golgi associated PDZ and coiled-coil motif containing protein
Chromosome 10
Common name 2210402P09Rik, GOPC1
Symbol description No Data
2 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 10
Common name No Data
Symbol description E. coli beta galactosidase
3 Symbol loxP
Symbol name phage P1 loxP
Chromosome 10
Common name No Data
Symbol description No Data
4 Symbol nls
Symbol name SV40 large T antigen nuclear localization signal (NLS)
Chromosome 10
Common name No Data
Symbol description No Data
5 Symbol poly A
Symbol name poly A
Chromosome 10
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
6 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 10
Common name neo; neomycin;
Symbol description No Data
References Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11211-6. Epub 2002 Jul 30.

Lack of acrosome formation in mice lacking a Golgi protein, GOPC.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Proc. Natl. Acad. Sci. USA, 99, 11211-11216 (2002).
It is agreed by the parties hereto that any patent or other intellectual property right to any inventions to be made by or derived of the use by the RECIPIENT of the BIOLOGICAL RESOURCE shall be jointly owned by the RECIPIENT and the DEPOSITOR. The share in the ownership on such patents etc. shall be agreed between the RECIPIENT and the DEPOSITOR. In the event that the RECIPIENT desires to file patent applications for such inventions, the RECIPIENT shall obtain a prior written consent of the DEVELOPER, Dr. Tetsuo Noda before the RECIPIENT files such patent applications.
The RECIPIENT should negotiate in good faith with the DEPOSITOR, or its representatives, to agree a fair and reasonable consideration to the DEPOSITOR in respect of the contribution to the said intellectual property rights afforded by the provision of the BIOLOGICAL RESOURCE hereunder.
The RECIPIENT must inform the DEPOSITOR the research project using the BIOLOGICAL RESOURCE and must obtain a prior permission from the DEPOSITOR to avoid the conflict of interest with the DEPOSITOR.
The RECIPIENT agrees to include the DEVELOPER, Dr. Tetsuo Noda as a co-author in any publications resulted by the use of the BIOLOGICAL RESOURCE during first 2 years after deposition by the DEPOSITOR to the RIKEN BRC.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Noda, Tetsuo (The CANCER INSTITUTE of the Japanese Foundation for Cancer Research) Noda, Tetsuo
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC01254, B6;129S4-Cnot7<tm1Tno>/Rbrc

RBRC No. RBRC01254
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129S4-Cnot7<tm1Tno>/Rbrc
Former Common name Cnot7 Knockout mouse
H-2 Haplotype No Data
ES cell line J1 [129S4/SvJae]
Donor strain 129S4/SvJae via J1 ES cell line
Background strain No Data
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Drs. Ryoji Yao, Tadashi Yamamoto, and Tetsuo Noda, Japanese Foundation for Cancer Research Cancer Institute in 1999. An exon of Cnot7 subcloned the 18-kb genomic DNA fragment, was replaced by the insertion of a LacZ and a floxed neo cassette. The floxed neo cassette was excised in this strain. This strain originated on a B6;129 background.
Strain description B6;129S4-Cnot7<tm1Tno>. Cnot7 gene (CCR4-NOT transcription complex. subunit 7) is essential for spermatogenesis. Cnot7 deficient male mice are sterile owing to oligo-astheno-teratozoospermia, impaired sperm motility, unsynchronized spermatid maturation, and Sertoli cell abnormalities. This knockout mouse strain is a powerful tool for understanding the mechanisms underlying spermatogenesis.
Colony maintenance Heterozygote x Wild-type
Homozygous mutant males are sterile.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Cnot7
Symbol name CCR4-NOT transcription complex, subunit 7
Chromosome 8
Common name Caf1
Symbol description No Data
2 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 8
Common name No Data
Symbol description E. coli beta galactosidase
3 Symbol loxP
Symbol name phage P1 loxP
Chromosome 8
Common name No Data
Symbol description No Data
4 Symbol nls
Symbol name SV40 large T antigen nuclear localization signal (NLS)
Chromosome 8
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
5 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 8
Common name neo; neomycin;
Symbol description No Data
References Nat Genet. 2004 May;36(5):528-33. Epub 2004 Apr 25.

Oligo-astheno-teratozoospermia in mice lacking Cnot7, a regulator of retinoid X receptor beta.
Research applications Cell Biology Research,
Genetics Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Nature Genetics, 36, 528-533 (2004).
It is agreed by the parties hereto that any patent or other intellectual property right to any inventions to be made by or derived of the use by the RECIPIENT of the BIOLOGICAL RESOURCE shall be jointly owned by the RECIPIENT and the DEPOSITOR. The share in the ownership on such patents etc. shall be agreed between the RECIPIENT and the DEPOSITOR. In the event that the RECIPIENT desires to file patent applications for such inventions, the RECIPIENT shall obtain a prior written consent of the DEVELOPER, Dr. Tetsuo Noda before the RECIPIENT files such patent applications.
The RECIPIENT should negotiate in good faith with the DEPOSITOR, or its representatives, to agree a fair and reasonable consideration to the DEPOSITOR in respect of the contribution to the said intellectual property rights afforded by the provision of the BIOLOGICAL RESOURCE hereunder.
The RECIPIENT must inform the DEPOSITOR the research project using the BIOLOGICAL RESOURCE and must obtain a prior permission from the DEPOSITOR to avoid the conflict of interest with the DEPOSITOR.
The RECIPIENT agrees to include the DEVELOPER, Dr. Tetsuo Noda as a co-author in any publications resulted by the use of the BIOLOGICAL RESOURCE during first 2 years after deposition by the DEPOSITOR to the RIKEN BRC.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Noda, Tetsuo (The CANCER INSTITUTE of the Japanese Foundation for Cancer Research) Noda, Tetsuo
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC01312, B6;129S4(Cg)-Ogg1<tm1.1Tno>

RBRC No. RBRC01312
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129S4(Cg)-Ogg1<tm1.1Tno>
Former Common name Mmh/Ogg1 Knockout Mouse
H-2 Haplotype No Data
Donor strain 129S4/SvJae via J1 ES cell line
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Ogg1
Symbol name 8-oxoguanine DNA-glycosylase 1
Chromosome 6
Common name Mmh
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 6
Common name No Data
Symbol description No Data
References Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4156-61.

Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice.
Research applications Cancer Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Proc. Natl. Acad. Sci. USA, 97, 4156-4161 (2000).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Noda, Tetsuo (The CANCER INSTITUTE of the Japanese Foundation for Cancer Research) Noda, Tetsuo
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC09696, C57BL/6J-Tg(SFTPC-CD74/ROS1)125Tno

RBRC No. RBRC09696
Type TransgeneCartagena
Species Mus musculus
Strain name C57BL/6J-Tg(SFTPC-CD74/ROS1)125Tno
Former Common name #125
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Tetsuo Noda, The Cancer Institute of JFCR. C57BL/6J background.
Strain description Mice model for the lung adenocarcinoma. Transgenice mice expressing CD74-ROS1 fusion protein under the control of the human SPC promoter.
Health Report
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name Flag tag (synthetic)
Chromosome UN
Common name No Data
Symbol description No Data
2 Symbol ROS1
Symbol name Ros1 proto-oncogene (human)
Chromosome UN
Common name No Data
Symbol description No Data
Promoter human SFTPC promoter
3 Symbol CD74
Symbol name CD74 antigen (human)
Chromosome UN
Common name No Data
Symbol description No Data
References No Data

Research applications Cancer Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Carcinogenesis, 37, 452-460 (2016).
For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Noda, Tetsuo (The CANCER INSTITUTE of the Japanese Foundation for Cancer Research) Noda, Tetsuo
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

Live
Live mouse :

RBRC09697, C57BL/6J-Tg(SFTPC-SDC4/ROS1)141Tno

RBRC No. RBRC09697
Type TransgeneCartagena
Species Mus musculus
Strain name C57BL/6J-Tg(SFTPC-SDC4/ROS1)141Tno
Former Common name #141
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Tetsuo Noda, The Cancer Institute of JFCR. C57BL/6J background.
Strain description Mice model for the lung adenocarcinoma. Transgenice mice expressing SDC4/ROS1 fusion protein under the control of the human SPC promoter.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol CD74
Symbol name CD74 antigen (human)
Chromosome UN
Common name No Data
Symbol description No Data
2 Symbol ROS1
Symbol name Ros1 proto-oncogene (human)
Chromosome UN
Common name No Data
Symbol description No Data
References No Data

Research applications Cancer Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Carcinogenesis, 37, 452-460 (2016).
For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Noda, Tetsuo (The CANCER INSTITUTE of the Japanese Foundation for Cancer Research) Noda, Tetsuo
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months