RBRC No. | RBRC00815 |
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Type | Targeted Mutation Congenic![]() |
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Species | Mus musculus molossinus | |||||||||||||||||||||||||||||||
Strain name | MSM.Cg-Trp53<tm1Sia>/JpkRbrc | |||||||||||||||||||||||||||||||
Former Common name | MSM-p53 KO | |||||||||||||||||||||||||||||||
H-2 Haplotype | No Data | |||||||||||||||||||||||||||||||
ES cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] | |||||||||||||||||||||||||||||||
Donor strain | B6.Cg-Trp53tm1Sia (と思われる) | |||||||||||||||||||||||||||||||
Background strain | MSM/Ms | |||||||||||||||||||||||||||||||
Appearance | ||||||||||||||||||||||||||||||||
1 | Appearance | white-bellied agouti | ||||||||||||||||||||||||||||||
Genotype | A |
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Strain development | Developed by Shinichi Aizawa, RIKEN Tsukuba Institute. The TT2 ES cells derived from B6CBAF1 were used to disrupt the p53 gene by homologous recombination. The mutant mice were backcrossed to C57BL/6, ICR and C3H, respectively by Ohtura Niwa, Radiation Biology Center, Kyoto University, to DBA/2 by Takeshi Yagi, Graduate School of Frontier Biosciences, Osaka University, to MSM by Ryo Kominami, Niigata University Graduate School of Medical and Dental Sciences. | |||||||||||||||||||||||||||||||
Strain description | Trp53 gene knockout mice. A neomycin selection cassette was inserted into the second exon of the Trp53 gene. Homozygous deficient mice can grow after birth, but often suffered from development of tumors in various region of the body. Several congenic strains were generated. C57BL/6 background (RBRC01361), ICR background (RBRC01348), C3H background (RBRC00107), DBA/2 background (RBRC01518), and MSM background (RBRC00815). In C57BL/6 background most of the female homozygotes die in utero (probably, also in MSM background). | |||||||||||||||||||||||||||||||
Colony maintenance | Heterozygote x Wild-type [or Crossing to MSM/Ms] | |||||||||||||||||||||||||||||||
Health Report |
BRC facility Health Report in the last year and a half
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Gene Details | ||||||||||||||||||||||||||||||||
Promoter | No Data | |||||||||||||||||||||||||||||||
1 | Symbol | Trp53 | ||||||||||||||||||||||||||||||
Symbol name | transformation-related protein 53 | |||||||||||||||||||||||||||||||
Chromosome | 11 | |||||||||||||||||||||||||||||||
Common name | p53 | |||||||||||||||||||||||||||||||
Symbol description | No Data | |||||||||||||||||||||||||||||||
Promoter | herpes simplex virus thymidine kinase promoter (HSV tk promoter) | |||||||||||||||||||||||||||||||
2 | Symbol | neo | ||||||||||||||||||||||||||||||
Symbol name | neomycin resistance gene (E. coli) | |||||||||||||||||||||||||||||||
Chromosome | 11 | |||||||||||||||||||||||||||||||
Common name | neo; neomycin; | |||||||||||||||||||||||||||||||
Symbol description | No Data | |||||||||||||||||||||||||||||||
References | Jpn J Cancer Res. 1996 Jul;87(7):696-701. Oncogene. 1993 Dec;8(12):3313-22. P53 gene deficiency does not enhance instability of mouse minisatellites in somatic cells of normal tissues.
P53 gene deficiency does not enhance instability of mouse minisatellites in somatic cells of normal tissues. |
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Research applications | Cancer Research, Cell Biology Research, Immunology and Inflammation Research, Mouse Models for Human Disease |
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Specific Term and Conditions | No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.) | |||||||||||||||||||||||||||||||
Additional information | ||||||||||||||||||||||||||||||||
1 | Mouse of the Month Jun 2005 | |||||||||||||||||||||||||||||||
2 | Genotyping protocol <PCR> | |||||||||||||||||||||||||||||||
Depositor | Kominami, Ryo (Niigata University, Graduate School of Science and Technology) ![]() |
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Strain Status / Availability (Expected delivery) |
Tag: A000252k
RBRC02421, C.Cg-Bcl11b<tm1Jpk>
RBRC No. | RBRC02421 |
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Type | Targeted Mutation![]() |
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Species | Mus musculus | |||||||||||||||||||||||||||||||
Strain name | C.Cg-Bcl11b<tm1Jpk> | |||||||||||||||||||||||||||||||
Former Common name | Bcl11b/Rit1-KO mice | |||||||||||||||||||||||||||||||
H-2 Haplotype | No Data | |||||||||||||||||||||||||||||||
ES cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] | |||||||||||||||||||||||||||||||
Background strain | No Data | |||||||||||||||||||||||||||||||
Appearance | ||||||||||||||||||||||||||||||||
1 | Appearance | albino | ||||||||||||||||||||||||||||||
Genotype | A/A b/b c/c | |||||||||||||||||||||||||||||||
Strain development | Developed by Ryo Kominami, Graduate School of Medical and Dental Science, Niigata University. TT2 ES cells derived from B6CBAF1 were used for the generation of knockout mice. C57BL/6 background (RBRC06231), BALB/c background (RBRC02421). | |||||||||||||||||||||||||||||||
Strain description | Bcl11b gene knock-out mice. A PGK-neo cassette was inserted into exon 1 of the Bcl11b gene. Bcl11b is a tumor-suppressor gene involved in T cell lymphomas. Homozygous mutant mice diw within the first day after birth. Mutant mice show a block at the CD4-CD8 double-negative stage of thymocyte development without any impairment in cells of B- or gammadelta T cell lineages. C57BL/6 background (RBRC06231), BALB/c background (RBRC02421). | |||||||||||||||||||||||||||||||
Colony maintenance | Heterozygote x Wild-type [BALB/cAJcl] | |||||||||||||||||||||||||||||||
Health Report |
BRC facility Health Report in the last year and a half
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Gene Details | ||||||||||||||||||||||||||||||||
Promoter | No Data | |||||||||||||||||||||||||||||||
1 | Symbol | Bcl11b | ||||||||||||||||||||||||||||||
Symbol name | B-cell leukemia/lymphoma 11B | |||||||||||||||||||||||||||||||
Chromosome | 12 | |||||||||||||||||||||||||||||||
Common name | 9130430L19Rik, B630002E05Rik, COUP-TF interacting protein 2, CTIP2, Rit1 | |||||||||||||||||||||||||||||||
Symbol description | No Data | |||||||||||||||||||||||||||||||
Promoter | mouse phosphoglycerate kinase promoter (PGK promoter) | |||||||||||||||||||||||||||||||
2 | Symbol | neo | ||||||||||||||||||||||||||||||
Symbol name | neomycin resistance gene (E. coli) | |||||||||||||||||||||||||||||||
Chromosome | 12 | |||||||||||||||||||||||||||||||
Common name | neo; neomycin; | |||||||||||||||||||||||||||||||
Symbol description | No Data | |||||||||||||||||||||||||||||||
References | ||||||||||||||||||||||||||||||||
Research applications | Immunology and Inflammation Research | |||||||||||||||||||||||||||||||
Specific Term and Conditions | The following terms and conditions will be requested by the DEPOSITOR. The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Immunol., 4, 533-539 (2003). The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE. |
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Additional information | ||||||||||||||||||||||||||||||||
1 | No Data | |||||||||||||||||||||||||||||||
2 | Genotyping protocol <PCR> | |||||||||||||||||||||||||||||||
Depositor | Kominami, Ryo (Niigata University, Graduate School of Science and Technology) ![]() |
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Strain Status / Availability (Expected delivery) |
RBRC06226, C57BL/6-Bcl11b<tm2.1Jpk>
RBRC No. | RBRC06226 |
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Type | Targeted Mutation![]() |
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Species | Mus musculus | |||||||||||||||||||||||||||||||
Strain name | C57BL/6-Bcl11b<tm2.1Jpk> | |||||||||||||||||||||||||||||||
Former Common name | B6-Bcl11b floxed | |||||||||||||||||||||||||||||||
H-2 Haplotype | No Data | |||||||||||||||||||||||||||||||
ES cell line | RENKA [C57BL/6NCrlCrlj] | |||||||||||||||||||||||||||||||
Background strain | C57BL/6JJcl | |||||||||||||||||||||||||||||||
Appearance | ||||||||||||||||||||||||||||||||
1 | Appearance | No Data | ||||||||||||||||||||||||||||||
Genotype | No Data | |||||||||||||||||||||||||||||||
Strain development | Developed by Ryo Kominami, Graduate School of Medical and Dental Science and Kenji Sakimura, Brain Research Institute, Niigata University. RENKA ES cells derived from C57BL/6NCrlCrlj were used for the generation of floxed mice. Neo cassette was removed by crossing with B6-CAG-FLPe mice (RBRC01824). C57BL/6 background (RBRC06226), BALB/c background (RBRC06229). | |||||||||||||||||||||||||||||||
Strain description | Bcl11b floxed mice. Exon 2 was flanked by loxP sites. C57BL/6 background (RBRC06226), BALB/c background (RBRC06229). | |||||||||||||||||||||||||||||||
Colony maintenance | Homozygote x Homozygote [or Crossing to C57BL/6JJcl] | |||||||||||||||||||||||||||||||
Health Report |
BRC facility Health Report in the last year and a half
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Gene Details | ||||||||||||||||||||||||||||||||
Promoter | No Data | |||||||||||||||||||||||||||||||
1 | Symbol | Bcl11b | ||||||||||||||||||||||||||||||
Symbol name | B cell leukemia/lymphoma 11B | |||||||||||||||||||||||||||||||
Chromosome | 12 | |||||||||||||||||||||||||||||||
Common name | No Data | |||||||||||||||||||||||||||||||
Symbol description | No Data | |||||||||||||||||||||||||||||||
2 | Symbol | Frt | ||||||||||||||||||||||||||||||
Symbol name | yeast FRT (flippase recombination target) site | |||||||||||||||||||||||||||||||
Chromosome | 12 | |||||||||||||||||||||||||||||||
Common name | No Data | |||||||||||||||||||||||||||||||
Symbol description | No Data | |||||||||||||||||||||||||||||||
3 | Symbol | loxP | ||||||||||||||||||||||||||||||
Symbol name | phage P1 loxP | |||||||||||||||||||||||||||||||
Chromosome | 12 | |||||||||||||||||||||||||||||||
Common name | No Data | |||||||||||||||||||||||||||||||
Symbol description | No Data | |||||||||||||||||||||||||||||||
4 | Symbol | loxP | ||||||||||||||||||||||||||||||
Symbol name | phage P1 loxP | |||||||||||||||||||||||||||||||
Chromosome | 12 | |||||||||||||||||||||||||||||||
Common name | No Data | |||||||||||||||||||||||||||||||
Symbol description | No Data | |||||||||||||||||||||||||||||||
References | ||||||||||||||||||||||||||||||||
Research applications | Cancer Research, Cre/loxP system, FLP/frt system |
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Specific Term and Conditions | The following terms and conditions will be requested by the DEPOSITOR. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. |
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Additional information | ||||||||||||||||||||||||||||||||
1 | No Data | |||||||||||||||||||||||||||||||
2 | Genotyping protocol <PCR> | |||||||||||||||||||||||||||||||
Depositor | Kominami, Ryo (Niigata University, Graduate School of Science and Technology) ![]() |
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Strain Status / Availability (Expected delivery) |
RBRC06227, B6(D2)-Bcl11b<Rgsc01891>
RBRC No. | RBRC06227 |
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Type | Chemically-induced Mutation | ![]() |
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Species | Mus musculus | ||||
Strain name | B6(D2)-Bcl11b<Rgsc01891> | ||||
Former Common name | B6-Bcl11b/S826G | ||||
H-2 Haplotype | No Data | ||||
Background strain | C57BL/6JJcl | ||||
Appearance | |||||
1 | Appearance | No Data | |||
Genotype | No Data | ||||
Strain development | Developed by Ryo Kominami, Graduate School of Medical and Dental Science and Mutagenesis and Genomics Team, RIKEN BioResrouce Center. Established by RIKEN ENU-base gene-driven mutagenesis. C57BL/6 background (RBRC06227), BALB/c background (RBRC06230). | ||||
Strain description | Bcl11b S826G variant ENU mutant mice. C57BL/6 background (RBRC06227), BALB/c background (RBRC06230). | ||||
Colony maintenance | Heterozygote x Wild-type [C57BL/6JJcl] | ||||
Health Report | No Data | ||||
Gene Details | |||||
Promoter | No Data | ||||
1 | Symbol | Bcl11b | |||
Symbol name | B cell leukemia/lymphoma 11B | ||||
Chromosome | 12 | ||||
Common name | No Data | ||||
Symbol description | No Data | ||||
References | |||||
Research applications | Cancer Research | ||||
Specific Term and Conditions | The following terms and conditions will be requested by the DEPOSITOR. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. |
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Additional information | |||||
1 | No Data | ||||
Depositor | Kominami, Ryo (Niigata University, Graduate School of Science and Technology) ![]() |
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Strain Status / Availability (Expected delivery) |
RBRC06228, B6(D2)-Bcl11b<Rgsc01839>
RBRC No. | RBRC06228 |
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Type | Chemically-induced Mutation | ![]() |
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Species | Mus musculus | ||||
Strain name | B6(D2)-Bcl11b<Rgsc01839> | ||||
Former Common name | B6-Bcl11b/C816ter | ||||
H-2 Haplotype | No Data | ||||
Background strain | C57BL/6JJcl | ||||
Appearance | |||||
1 | Appearance | No Data | |||
Genotype | No Data | ||||
Strain development | Developed by Ryo Kominami, Graduate School of Medical and Dental Science and Mutagenesis and Genomics Team, RIKEN BioResrouce Center. Established by RIKEN ENU-base gene-driven mutagenesis. C57BL/6 background. | ||||
Strain description | Bcl11b C816ter variant ENU mutant mice. | ||||
Colony maintenance | Heterozygote x Wild-type [C57BL/6JJcl] | ||||
Health Report | No Data | ||||
Gene Details | |||||
Promoter | No Data | ||||
1 | Symbol | Bcl11b | |||
Symbol name | B cell leukemia/lymphoma 11B | ||||
Chromosome | 12 | ||||
Common name | No Data | ||||
Symbol description | No Data | ||||
References | Unpublished | ||||
Research applications | Cancer Research | ||||
Specific Term and Conditions | The following terms and conditions will be requested by the DEPOSITOR. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. |
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Additional information | |||||
1 | No Data | ||||
Depositor | Kominami, Ryo (Niigata University, Graduate School of Science and Technology) ![]() |
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Strain Status / Availability (Expected delivery) |
RBRC06229, C.B6-Bcl11b<tm2.1Jpk>
RBRC No. | RBRC06229 |
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Type | Targeted Mutation![]() |
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Species | Mus musculus | ||||
Strain name | C.B6-Bcl11b<tm2.1Jpk> | ||||
Former Common name | BALB-Bcl11b floxed | ||||
H-2 Haplotype | No Data | ||||
ES cell line | RENKA [C57BL/6NCrlCrlj] | ||||
Background strain | BALB/cAJcl | ||||
Appearance | |||||
1 | Appearance | No Data | |||
Genotype | No Data | ||||
Strain development | Developed by Ryo Kominami, Graduate School of Medical and Dental Science and Kenji Sakimura, Brain Research Institute, Niigata University. RENKA ES cells derived from C57BL/6NCrlCrlj were used for the generation of floxed mice. Neo cassette was removed by crossing with B6-CAG-FLPe mice (RBRC01824). C57BL/6 background (RBRC06226), BALB/c background (RBRC06229). | ||||
Strain description | Bcl11b floxed mice. Exon 2 was flanked by loxP sites. C57BL/6 background (RBRC06226), BALB/c background (RBRC06229). | ||||
Colony maintenance | Homozygote x Homozygote [or Crossing to BALB/cAJcl] | ||||
Health Report | No Data | ||||
Gene Details | |||||
Promoter | No Data | ||||
1 | Symbol | Bcl11b | |||
Symbol name | B cell leukemia/lymphoma 11B | ||||
Chromosome | 12 | ||||
Common name | No Data | ||||
Symbol description | No Data | ||||
2 | Symbol | Frt | |||
Symbol name | yeast FRT (flippase recombination target) site | ||||
Chromosome | 12 | ||||
Common name | No Data | ||||
Symbol description | No Data | ||||
3 | Symbol | loxP | |||
Symbol name | phage P1 loxP | ||||
Chromosome | 12 | ||||
Common name | No Data | ||||
Symbol description | No Data | ||||
References | |||||
Research applications | Cancer Research, Cre/loxP system, FLP/frt system |
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Specific Term and Conditions | The following terms and conditions will be requested by the DEPOSITOR. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. |
||||
Additional information | |||||
1 | No Data | ||||
Depositor | Kominami, Ryo (Niigata University, Graduate School of Science and Technology) ![]() |
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Strain Status / Availability (Expected delivery) |
RBRC06230, C.B6(D2)-Bcl11b<Rgsc01891>
RBRC No. | RBRC06230 |
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Type | Chemically-induced Mutation | ![]() |
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Species | Mus musculus | ||||
Strain name | C.B6(D2)-Bcl11b<Rgsc01891> | ||||
Former Common name | BALB-Bcl11b/S826G | ||||
H-2 Haplotype | No Data | ||||
Background strain | BALB/cAJcl | ||||
Appearance | |||||
1 | Appearance | No Data | |||
Genotype | No Data | ||||
Strain development | Developed by Ryo Kominami, Graduate School of Medical and Dental Science and Mutagenesis and Genomics Team, RIKEN BioResrouce Center. Established by RIKEN ENU-base gene-driven mutagenesis. C57BL/6 background (RBRC06227), BALB/c background (RBRC06230). | ||||
Strain description | Bcl11b S826G variant ENU mutant mice. C57BL/6 background (RBRC06227), BALB/c background (RBRC06230). | ||||
Colony maintenance | Heterozygote x Wild-type [BALB/cAJcl] | ||||
Health Report | No Data | ||||
Gene Details | |||||
Promoter | No Data | ||||
1 | Symbol | Bcl11b | |||
Symbol name | B cell leukemia/lymphoma 11B | ||||
Chromosome | 12 | ||||
Common name | No Data | ||||
Symbol description | No Data | ||||
References | |||||
Research applications | Cancer Research | ||||
Specific Term and Conditions | The following terms and conditions will be requested by the DEPOSITOR. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. |
||||
Additional information | |||||
1 | No Data | ||||
Depositor | Kominami, Ryo (Niigata University, Graduate School of Science and Technology) ![]() |
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Strain Status / Availability (Expected delivery) |
RBRC06231, B6.Cg-Bcl11b<tm1Jpk>
RBRC No. | RBRC06231 |
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Type | Targeted Mutation![]() |
![]() |
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Species | Mus musculus | ||||
Strain name | B6.Cg-Bcl11b<tm1Jpk> | ||||
Former Common name | B6-Bcl11b KO | ||||
H-2 Haplotype | No Data | ||||
ES cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] | ||||
Background strain | No Data | ||||
Appearance | |||||
1 | Appearance | No Data | |||
Genotype | No Data | ||||
Strain development | Developed by Ryo Kominami, Graduate School of Medical and Dental Science, Niigata University. TT2 ES cells derived from B6CBAF1 were used for the generation of knockout mice. C57BL/6 background (RBRC06231), BALB/c background (RBRC02421). | ||||
Strain description | Bcl11b gene knock-out mice. A PGK-neo cassette was inserted into exon 1 of the Bcl11b gene. Bcl11b is a tumor-suppressor gene involved in T cell lymphomas. Homozygous mutant mice diw within the first day after birth. Mutant mice show a block at the CD4-CD8 double-negative stage of thymocyte development without any impairment in cells of B- or gammadelta T cell lineages. C57BL/6 background (RBRC06231), BALB/c background (RBRC02421). | ||||
Colony maintenance | Heterozygote x Wild-type [C57BL/6JJcl] | ||||
Health Report | No Data | ||||
Gene Details | |||||
Promoter | No Data | ||||
1 | Symbol | Bcl11b | |||
Symbol name | B cell leukemia/lymphoma 11B | ||||
Chromosome | 12 | ||||
Common name | No Data | ||||
Symbol description | No Data | ||||
Promoter | mouse phosphoglycerate kinase promoter (PGK promoter) | ||||
2 | Symbol | neo | |||
Symbol name | neomycin resistance gene (E. coli) | ||||
Chromosome | 12 | ||||
Common name | No Data | ||||
Symbol description | No Data | ||||
References | |||||
Research applications | Cancer Research | ||||
Specific Term and Conditions | The following terms and conditions will be requested by the DEPOSITOR. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Immunol., 4, 533-539 (2003). The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
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Additional information | |||||
1 | No Data | ||||
Depositor | Kominami, Ryo (Niigata University, Graduate School of Science and Technology) ![]() |
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Strain Status / Availability (Expected delivery) |