RBRC00752, B6.129P2-Tnfrsf5<tm1Kik>/Rbrc

RBRC No. RBRC00752
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129P2-Tnfrsf5<tm1Kik>/Rbrc
Former Common name CD40 Knockout mice
H-2 Haplotype No Data
ES cell line E14.1 [129P2/OlaHsd]
Donor strain 129P2/OlaHsd via E14.1 ES cell line
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Hitoshi Kikutani, Institute for Molecular and Cellular Biology, Osaka University in 1994.
Strain description CD40 knockout mice. Exon 3 of the CD40 was replaced with a neo cassette. CD40/Tnfrsf5 (tumor necrosis factor receptor superfamily, member 5) is essential for T cell-dependent immunoglobulin class switching and germinal center formation. Homozygous mutant mice for CD40 targeted mutation exhibit impaired immunoglobulin class switching, and the germinal center formation was defective. Homozygous mice are viable and fertile.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Tnfrsf5
Symbol name tumor necrosis factor receptor superfamily, member 5
Chromosome 2
Common name Bp50, Cd40, IGM, p50
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 2
Common name neo; neomycin;
Symbol description No Data
References Immunity. 1994 Jun;1(3):167-78.

The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation.
Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Immunity, 1, 167-178 (1994).
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Kikutani, Hitoshi (Osaka university) Kikutani, Hitoshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC00753, B6;129P2-Sema4d<tm1Kik>/Rbrc

RBRC No. RBRC00753
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129P2-Sema4d<tm1Kik>/Rbrc
Former Common name CD100 Knockout mice
H-2 Haplotype No Data
ES cell line E14.1 [129P2/OlaHsd]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Sema4d
Symbol name sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Chromosome 13
Common name CD100, coll-4, M-sema G, Semacl2, SEMAJ, Semaj, semaphorin H, Semcl2
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 13
Common name neo; neomycin;
Symbol description No Data
References Immunity. 2000 Nov;13(5):633-42.

The class IV semaphorin CD100 plays nonredundant roles in the immune system: defective B and T cell activation in CD100-deficient mice.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Immunity, 13, 633-642 (2000).
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Kikutani, Hitoshi (Osaka university) Kikutani, Hitoshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Sema4D is required in both the adaptive and innate immune responses of contact hypersensitivity. Mol Immunol.78: 98-104 (2016).(27614265)
Zhu Z, Luo Y, Yu J, Gao J, Zhang Y, Xiao C, Zhang C, Wang G, Liu Y, Fu M, Yao X, Li W.

RBRC00754, B6.Cg-Cd40<tm1Kik> Tg(Igh-CD40)1Kik/Rbrc

RBRC No. RBRC00754
Type Targeted Mutation and TransgeneCartagena
Species Mus musculus
Strain name B6.Cg-Cd40<tm1Kik> Tg(Igh-CD40)1Kik/Rbrc
Former Common name CD40 transgenic mice
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Hitoshi Kikutani, Research Institute for Microbial Diseases, Osaka University in 2002.
Strain description Transgenic mice expressing wild-type human CD40 gene in a mouse CD40 deficient background. CD40/Tnfrsf5 (tumor necrosis factor receptor superfamily, member 5) is essential for T cell-dependent immunoglobulin class switching and germinal center formation.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Tnfrsf5
Symbol name tumor necrosis factor receptor superfamily, member 5
Chromosome 2
Common name Bp50, Cd40, IGM, p50
Symbol description No Data
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 2
Common name neo; neomycin;
Symbol description No Data
Promoter mouse E m, IgH promoter, rabbit beta-globin poly A
3 Symbol TNFRSF5
Symbol name tumor necrosis factor receptor superfamily, member 5 (human)
Chromosome UN
Common name Bp50, Cd40, IGM, p50
Symbol description No Data
References Int Immunol. 2002 Mar;14(3):319-29.
Nature. 1985 Jul 4-10;316(6023):67-9.

Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals.
Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals.
Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Inter. Immunol., 14, 319-329 (2002).
Additional information
1 No Data
Depositor Kikutani, Hitoshi (Osaka university) Kikutani, Hitoshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00755, B6;129P2-Fcer2a<tm1Kik>/KikRbrc

RBRC No. RBRC00755
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129P2-Fcer2a<tm1Kik>/KikRbrc
Former Common name CD23 Knockout mice
H-2 Haplotype No Data
ES cell line E14.1 [129P2/OlaHsd]
Donor strain 129P2/OlaHsd via E14-1 ES cell line
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Fcer2a
Symbol name Fc receptor, IgE, low affinity II, alpha polypeptide
Chromosome 8
Common name CD23, FC epsilon RII, Fce2, low-affinity IgE receptor, Ly-42
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 8
Common name neo; neomycin;
Symbol description No Data
References J Immunol. 1991 Aug 1;147(3):1067-74.
Proc Natl Acad Sci U S A 1994 Jul 19;91(15):6835-9.

Complete genomic sequence of the murine low affinity Fc receptor for IgE. Demonstration of alternative transcripts and conserved sequence elements.
Complete genomic sequence of the murine low affinity Fc receptor for IgE. Demonstration of alternative transcripts and conserved sequence elements.
Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Proc. Natl. Acad. Sci. USA, 91, 6835-6839 (1994).
Additional information
1 Genetic Background
2 Genotyping protocol <PCR>
Depositor Kikutani, Hitoshi (Osaka university) Kikutani, Hitoshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Dendritic cells suppress IgE production in B cells. Int Immunol.19(2): 217-26 (2007).(17208926)
Obayashi K, Doi T, Koyasu S.