RBRC00688, B6;129S-Psap<tm2Suz>/JumaRbrc

RBRC No. RBRC00688
Type Targeted MutationCartagena 6wks,♂
Species Mus musculus
Strain name B6;129S-Psap<tm2Suz>/JumaRbrc
Former Common name mouse saposin A mutant mouse
H-2 Haplotype No Data
Donor strain 129/SvEv
Background strain C57BL/6JJcl
Appearance
1 Appearance black
Genotype No Data
2 Appearance brown
Genotype No Data
Strain development 2001, Junko Matsuda, M.D. and Kunihiko Suzuki, M.D.
Neuroscience Center, Departments of neurology and Psychiatry, University of North Carolina, Chapel Hill, NC 27599-7250, U.S.A.
Strain description Neurobiology Research, Metabolic Defects, Lysosomal Disease, Demyelinating disease
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Psap
Symbol name prosaposin
Chromosome 10
Common name SGP-1, saposin A
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 10
Common name No Data
Symbol description No Data
References Hum Mol Genet. 2001 May 15;10(11):1191-9.
Hum Mol Genet. 2001 Nov 1;10(23):2709-15.

A mutation in the saposin A domain of the sphingolipid activator protein (prosaposin) gene results in a late-onset, chronic form of globoid cell leukodystrophy in the mouse.
A mutation in the saposin A domain of the sphingolipid activator protein (prosaposin) gene results in a late-onset, chronic form of globoid cell leukodystrophy in the mouse.
Research applications Cre/loxP system,
Metabolism Research,
Mouse Models for Human Disease,
Neurobiology Research
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Matsuda, Junko (The University of Tokushima) Matsuda, Junko
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC00690, B6;129P2-Glb1<tm11Azzo>/Rbrc

RBRC No. RBRC00690
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6;129P2-Glb1<tm11Azzo>/Rbrc
Former Common name beta-galactosidase Knockout mice
H-2 Haplotype No Data
ES cell line E14 [129P2/OlaHsd]
Donor strain (C57BL/6 x CBA)F1 via TT2 ES cell line
Background strain C57BL/6JJcl
Appearance
1 Appearance black
Genotype No Data
Strain development 1997, Kunihiko Suzuki, M.D.
Departments of neurology and Psychiatry, University of North Carolina, Chapel Hill, NC 27599-7250, U.S.A.
Strain description Neurobiology Research, Metabolic Defects, Lysosomal Storage Disease
Colony maintenance Heterozygote X Heterozygote
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Glb1
Symbol name galactosidase, beta 1
Chromosome 9
Common name Bge, Bgl, Bgl-e, Bgl-s, Bgl-t, Bgs, Bgt
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 9
Common name neo; neomycin;
Symbol description No Data
References Hum Mol Genet. 1997 Feb;6(2):205-11.

Generalized CNS disease and massive GM1-ganglioside accumulation in mice defective in lysosomal acid beta-galactosidase.
Research applications Metabolism Research,
Neurobiology Research
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Matsuda, Junko (The University of Tokushima) Matsuda, Junko
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC01293, B6;129-Psap<tm1Juma>/Rbrc

RBRC No. RBRC01293
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129-Psap<tm1Juma>/Rbrc
Former Common name Saposin D mutant mouse
H-2 Haplotype No Data
Donor strain 129/SvEv
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Dr. Junko Matsuda, the University of Tokushima Graduate School and Dr. Kunihiko Suzuki, University of North Carolina at 2004.
Strain description Homozygous mutant mice exhibit renal tubular degeneration around 2 months, and a cerebellar Purkinje cell degeneration around 4 months with accumulation of hydroxy fatty acid-containing ceramide. Average life sopan is 10-15 months.
Colony maintenance Backcross to C57BL/6 (Heterozygote x C57BL/6JJcl)
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Psap
Symbol name prosaposin
Chromosome 10
Common name SGP-1, snoRNA MBII-198
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 10
Common name No Data
Symbol description No Data
References Hum Mol Genet 2004 Nov 1;13(21):2709-23. Epub 2004 Sep 2.

Mutation in saposin D domain of sphingolipid activator protein gene causes urinary system defects and cerebellar Purkinje cell degeneration with accumulation of hydroxy fatty acid-containing ceramide in mouse.
Research applications Cre/loxP system,
Neurobiology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Hum. Mol. Genet., 13, 2709-2723 (2004).
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Matsuda, Junko (The University of Tokushima) Matsuda, Junko
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months