RBRC06153, B6.Cg-Tg(TOPGAL) Ctnnb1<Rgsc1880>

RBRC No. RBRC06153
Type TransgeneCartagena
Species Mus musculus
Strain name B6.Cg-Tg(TOPGAL) Ctnnb1<Rgsc1880>
Former Common name TOPGAL;Ctnnb1/C429S (B6), B6-TOPGAL Ctnnb1/C429S
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Takuya Murata and Yoichi Gondo, RIKEN BioResource center in 2012. C57BL/6J background.
Strain description Ins-TOPGAL and Ctnnb1 C429S mutant mice. Ctnnb1 C429S mutant mice were generated by ENU mutagenesis. C492S homozygous mutant mice are infertile. Ins-TOPGAL transgenic mice are useful for visualizing Wnt signal pathway. The transgene contains the nLacZ gene under the control of a TOPFLASH promoter (6x TCF binding motifs upstream of a TK promoter). The transgene construct was flanked by the insulator core elements.
Colony maintenance Tg: Carrier x Noncarrier [C57BL/6JJcl]; Ctnnb1: Heterozygote x Wild-type [C57BL/6JJcl]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol nls
Symbol name SV40 large T antigen nuclear localization signal (NLS)
Chromosome UN
Common name No Data
Symbol description No Data
Promoter TOPFLUSH promoter
2 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome UN
Common name No Data
Symbol description No Data
References Nat Rev Genet. 2008 Oct;9(10):803-10.

Trends in large-scale mouse mutagenesis: from genetics to functional genomics.
Trends in large-scale mouse mutagenesis: from genetics to functional genomics.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
後日指定。(will be announced).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Additional information
1 Mouse of the Month Nov 2014
Depositor Gondo, Yoichi (RIKEN, BioResource Center) Gondo, Yoichi
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC06154, B6(D2)-Ctnnb1<Rgsc1880>

RBRC No. RBRC06154
Type Chemically-induced Mutation
Species Mus musculus
Strain name B6(D2)-Ctnnb1<Rgsc1880>
Former Common name Ctnnb1 C429S, Ctnnb1 (B6), B6-Ctnnb1/C429S
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Takuya Murata and Yoichi Gondo, RIKEN BioResource center. C57BL/6J background (over N21 generations).
Strain description Ctnnb1 C429S mutant mice. Ctnnb1 C429S mutant mice were generated by ENU mutagenesis. Homozygous mutant mice are infertile.
Colony maintenance Heterozygote x Wild-type [C57BL/6JJcl]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Ctnnb1
Symbol name catenin (cadherin associated protein), beta 1
Chromosome 9
Common name No Data
Symbol description No Data
References Nat Rev Genet. 2008 Oct;9(10):803-10.

Trends in large-scale mouse mutagenesis: from genetics to functional genomics.
Trends in large-scale mouse mutagenesis: from genetics to functional genomics.
Research applications Developmental Biology Research,
Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Scientific Reports 4, 6959 (2014).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Additional information
1 Mouse of the Month Nov 2014
Depositor Gondo, Yoichi (RIKEN, BioResource Center) Gondo, Yoichi
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC06556, B6(D2)-Sufu<Rgsc2062>

RBRC No. RBRC06556
Type Chemically-induced Mutation
Species Mus musculus
Strain name B6(D2)-Sufu<Rgsc2062>
Former Common name SufuT396I, B6-Sufu/T396I
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Shigeru Makino and Yoichi Gondo, RIKEN BioResource center. Generated by RIKEN ENU-based gene driven mutagenesis. The mutant mice were backcrossed to C57BL/6J.
Strain description Sufu gene ENU mutant mice. Sufu<Rgsc2062>(T396I variant)(RBRC06556): Homozygous mutant mice are embryonic lethal. Sufu<Rgsc2075>(R396X variant)(RBRC06557): Homozygous mutant mice die around E10.
Colony maintenance Heterozygote x Wild-type [C57BL/6JJcl]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Sufu
Symbol name suppressor of fused homolog (Drosophila)
Chromosome 19
Common name No Data
Symbol description No Data
References Nat Rev Genet. 2008 Oct;9(10):803-10.

Trends in large-scale mouse mutagenesis: from genetics to functional genomics.
Research applications Cancer Research,
Developmental Biology Research,
Neurobiology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
後日指定。(will be announced).
Additional information
1 No Data
Depositor Gondo, Yoichi (RIKEN, BioResource Center) Gondo, Yoichi
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC06557, B6(D2)-Sufu<Rgsc2075>

RBRC No. RBRC06557
Type Chemically-induced Mutation
Species Mus musculus
Strain name B6(D2)-Sufu<Rgsc2075>
Former Common name SufuR146X, B6-Sufu/R146X
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Shigeru Makino and Yoichi Gondo, RIKEN BioResource center. Generated by RIKEN ENU-based gene driven mutagenesis. The mutant mice were backcrossed to C57BL/6J.
Strain description Sufu gene ENU mutant mice. Sufu<Rgsc2062>(T396I variant)(RBRC06556): Homozygous mutant mice are embryonic lethal. Sufu<Rgsc2075>(R396X variant)(RBRC06557): Homozygous mutant mice die around E10.
Colony maintenance Heterozygote x Wild-type [C57BL/6JJcl]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Sufu
Symbol name suppressor of fused homolog (Drosophila)
Chromosome 19
Common name No Data
Symbol description No Data
References Nat Rev Genet. 2008 Oct;9(10):803-10.

Trends in large-scale mouse mutagenesis: from genetics to functional genomics.
Research applications Cancer Research,
Developmental Biology Research,
Neurobiology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
後日指定。(will be announced).
Additional information
1 No Data
Depositor Gondo, Yoichi (RIKEN, BioResource Center) Gondo, Yoichi
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC06558, B6(D2)-Smo<Rgsc2073>

RBRC No. RBRC06558
Type Chemically-induced Mutation
Species Mus musculus
Strain name B6(D2)-Smo<Rgsc2073>
Former Common name SmoG457X, B6-Smo/G457X
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Shigeru Makino and Yoichi Gondo, RIKEN BioResource center. Generated by RIKEN ENU-based gene driven mutagenesis. The mutant mice were backcrossed to C57BL/6J.
Strain description Smo gene G457X variant mice. Homozygous mutant mice die around E10.
Colony maintenance Heterozygote x Wild-type [C57BL/6JJcl]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Smo
Symbol name smoothened homolog (Drosophila)
Chromosome 6
Common name No Data
Symbol description No Data
References Nat Rev Genet. 2008 Oct;9(10):803-10.

Trends in large-scale mouse mutagenesis: from genetics to functional genomics.
Research applications Cancer Research,
Developmental Biology Research,
Neurobiology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
後日指定。(will be announced).
Additional information
1 No Data
Depositor Gondo, Yoichi (RIKEN, BioResource Center) Gondo, Yoichi
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC10044, B6(D2)-Sufu<Rgsc1185>

RBRC No. RBRC10044
Type Chemically-induced Mutation
Species Mus musculus
Strain name B6(D2)-Sufu<Rgsc1185>
Former Common name SufuS290G
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Sufu
Symbol name suppressor of fused homolog (Drosophila)
Chromosome 19
Common name No Data
Symbol description No Data
References No Data

Research applications Cancer Research,
Developmental Biology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
PLoS One. 2015 Mar 11;10(3):e0119455. doi: 10.1371/journal.pone.0119455.
Additional information
1 No Data
Depositor Gondo, Yoichi (RIKEN, BioResource Center) Gondo, Yoichi
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC10045, B6(D2)-Sufu<Rgsc2027>

RBRC No. RBRC10045
Type Chemically-induced Mutation
Species Mus musculus
Strain name B6(D2)-Sufu<Rgsc2027>
Former Common name SufuE260K
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Sufu
Symbol name suppressor of fused homolog (Drosophila)
Chromosome 19
Common name No Data
Symbol description No Data
References No Data

Research applications Cancer Research,
Developmental Biology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
PLoS One. 2015 Mar 11;10(3):e0119455. doi: 10.1371/journal.pone.0119455.
Additional information
1 No Data
Depositor Gondo, Yoichi (RIKEN, BioResource Center) Gondo, Yoichi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC10046, B6(D2)-Sufu<Rgsc2029>

RBRC No. RBRC10046
Type Chemically-induced Mutation
Species Mus musculus
Strain name B6(D2)-Sufu<Rgsc2029>
Former Common name SufuI291N
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Sufu
Symbol name suppressor of fused homolog (Drosophila)
Chromosome 19
Common name No Data
Symbol description No Data
References No Data

Research applications Cancer Research,
Developmental Biology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
PLoS One. 2015 Mar 11;10(3):e0119455. doi: 10.1371/journal.pone.0119455.
Additional information
1 No Data
Depositor Gondo, Yoichi (RIKEN, BioResource Center) Gondo, Yoichi
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC10047, B6(D2)-Sufu<Rgsc2070>

RBRC No. RBRC10047
Type Chemically-induced Mutation
Species Mus musculus
Strain name B6(D2)-Sufu<Rgsc2070>
Former Common name SufuS157R
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Sufu
Symbol name suppressor of fused homolog (Drosophila)
Chromosome 19
Common name No Data
Symbol description No Data
References No Data

Research applications Cancer Research,
Developmental Biology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
PLoS One. 2015 Mar 11;10(3):e0119455. doi: 10.1371/journal.pone.0119455.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Gondo, Yoichi (RIKEN, BioResource Center) Gondo, Yoichi
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC10048, B6(D2)-Sufu<Rgsc2071>

RBRC No. RBRC10048
Type Chemically-induced Mutation
Species Mus musculus
Strain name B6(D2)-Sufu<Rgsc2071>
Former Common name SufuL68S
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Sufu
Symbol name suppressor of fused homolog (Drosophila)
Chromosome 19
Common name No Data
Symbol description No Data
References No Data

Research applications Cancer Research,
Developmental Biology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
PLoS One. 2015 Mar 11;10(3):e0119455. doi: 10.1371/journal.pone.0119455.
Additional information
1 No Data
Depositor Gondo, Yoichi (RIKEN, BioResource Center) Gondo, Yoichi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months