RBRC02711, B6.129S-Osmr<tm1Mtan>

RBRC No. RBRC02711
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6.129S-Osmr<tm1Mtan>
Former Common name Oncostatin M receptor knockout mouse, OSMR-KO
H-2 Haplotype No Data
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]
Background strain C57BL/6NCrSlc
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Dr. Minoru Tanaka in 1999.
Strain description Osmr knock-out mice. Osmr, Oncostain M receptor is an alternative subunit that activated by Osm. Osm is a multifunctional cytokine that belongs to the interleukin 6 family, considered to play a role in hematopoiesis. Homozygous mutant mice are viable and fertile, but show a mild anemia and recovery delay of erythrocytes from chemically induced acute hemolysis.
Colony maintenance Heterozygote x Wild-type [C57BL/6CrSlc]
Health Report
Gene Details
Promoter No Data
1 Symbol Osmr
Symbol name oncostatin M receptor
Chromosome 15
Common name OSMRB
Symbol description No Data
2 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 15
Common name No Data
Symbol description E. coli beta galactosidase
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 15
Common name neo; neomycin;
Symbol description No Data
References Blood 2003 Nov 1;102(9):3154-62. Epub 2003 Jul 10.
Hepatology 2004 Mar;39(3):635-44.

Targeted disruption of oncostatin M receptor results in altered hematopoiesis.
Targeted disruption of oncostatin M receptor results in altered hematopoiesis.
Research applications Hematological Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Blood, 102, 3154-3162 (2003). Hepatology, 39, 635-644 (2004).
The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEVELOPER (Chiome Bioscience Inc. Email:knakamura@chiome.co.jp).
Additional information
1 Lab HP (Japanese)
2 Genotyping protocol <PCR>
Depositor Miyajima, Atsushi (The University of Tokyo) Miyajima, Atsushi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Oncostatin M protects against demyelination by inducing a protective microglial phenotype. Glia (2015).(25921393)
Janssens K, Maheshwari A, Van den Haute C, Baekelandt V, Stinissen P, Hendriks JJ, Slaets H, Hellings N.
Oncostatin M Confers Neuroprotection against Ischemic Stroke. J. Neurosci.35(34): 12047-62. (2015).(26311783)
Guo S, Li ZZ, Gong J, Xiang M, Zhang P, Zhao GN, Li M, Zheng A, Zhu X, Lei H, Minoru T, Li H.
The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction. Nat Commun. (2017).(28067314)
Yamamura K, Uruno T, Shiraishi A, Tanaka Y, Ushijima M, Nakahara T, Watanabe M, Kido-Nakahara M, Tsuge I, Furue M, Fukui Y.

RBRC02796, B6.Cg-Stab2<tm1>

RBRC No. RBRC02796
Type Targeted Mutation CongenicCartagena
Species Mus musculus
Strain name B6.Cg-Stab2<tm1>
Former Common name Stab2-KO
H-2 Haplotype No Data
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 10
Common name neo; neomycin;
Symbol description No Data
2 Symbol Stab2
Symbol name stabilin 2
Chromosome 10
Common name No Data
Symbol description No Data
3 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 10
Common name No Data
Symbol description E. coli beta galactosidase
References

Research applications Fluorescent Proteins/lacZ System
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR.
Additional information
1 Lab HP (Japanese)
2 Genotyping protocol <PCR>
Depositor Miyajima, Atsushi (The University of Tokyo) Miyajima, Atsushi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Co-Administration of an Excipient Oligonucleotide Helps Delineate Pathways of Productive and Nonproductive Uptake of Phosphorothioate Antisense Oligonucleotides in the Liver. Nucleic Acid Ther27(4): 209-220 (2017).(28448194)
Donner AJ, Wancewicz EV, Murray HM, Greenlee S, Post N, Bell M, Lima WF, Swayze EE, Seth PP.
Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1. PLoS Genet. (2018).(30372444)
Pirie E, Ray S, Pan C, Fu W, Powers AF, Polikoff D, Miller CM, Kudrna KM, Harris EN, Lusis AJ, Crooke RM, Lee RG.

RBRC03897, B6.129P2-Glg1<Gt(KST005)Byg>

RBRC No. RBRC03897
Type Gene Trap
Species Mus musculus
Strain name B6.129P2-Glg1<Gt(KST005)Byg>
Former Common name Cfr KO
H-2 Haplotype No Data
Background strain C57BL/6
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name No Data
Chromosome No Data
Common name No Data
Symbol description No Data
References Development. 2010 Jan;137(1):159-67.

A novel regulatory mechanism for Fgf18 signaling involving cysteine-rich FGF receptor (Cfr) and delta-like protein (Dlk).
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Development, 137, 159-167 (2010).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and the founders of BayGenomics, and must obtain a prior written consent from the DEPOSITOR and the founders of BayGenomics.
Additional information
1 Lab HP (Japanese)
Depositor Miyajima, Atsushi (The University of Tokyo) Miyajima, Atsushi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
A novel regulatory mechanism for Fgf18 signaling involving cysteine-rich FGF receptor (Cfr) and delta-like protein (Dlk). Development.137(1): 159-67 (2010).(20023171)
Miyaoka Y, Tanaka M, Imamura T, Takada S, Miyajima A.

RBRC01491, B6;B6CB-Lrrn4<tm1>/Rbrc

RBRC No. RBRC01491
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;B6CB-Lrrn4<tm1>/Rbrc
Former Common name NLRR4-KO(B6); B6.Cg-B430119L13Rik
H-2 Haplotype No Data
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Donor strain (C57BL/6 x CBA)F1 via TT2 ES cell line
Background strain No Data
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Drs. Takayoshi Bando and Atsushi Miyajima at the University of Tokyo in 2001. The TT2 ES cells originated from an F1 embryo between C57BL/6 and CBA mice were used. The targeting construct contains relpaced exons with the beta-galactosidase and the neomycin resistance genes by homologous reconbination. The NLRR4 deficient mice were backcrossed to C57BL/6JJcl.
Strain description B6.Cg-B430119L13Rik<tm>. NLRR4 is a member of the neuronal leucine-rich repeat protein family. NLRR proteins are type I transmembrane proteins with leucine-rich repeats and a fibronectine type III repeat, and expressed in neuronal tissues. NLRR4 deficient mice have a severe damage to their long-term memory in hippocampus-dependent tasks, while their hippocampal long-term potentiation was intact. NLRR4 plays a role in hippocamus-dependent long-lasting memory.
Colony maintenance Backcross to C57BL/6 (Heterozygote x C57BL/6J)
Homozygous deficient mice are viable and fertile.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Lrrn4
Symbol name leucine rich repeat neuronal 4
Chromosome 2
Common name B430119L13Rik
Symbol description No Data
2 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 2
Common name No Data
Symbol description E. coli beta galactosidase
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 2
Common name neo; neomycin;
Symbol description No Data
References Mol Cell Biol 2005 May;25(10):4166-75.

Neuronal leucine-rich repeat protein 4 functions in hippocampus-dependent long-lasting memory.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Mol. Cell Biol., 10, 4160-4175 (2005).
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
Additional information
1 Lab HP (Japanese)
2 Genotyping protocol <PCR>
Depositor Miyajima, Atsushi (The University of Tokyo) Miyajima, Atsushi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months