RBRC05744, B6.Cg-Tg(Grm6-cre)7Tfur

RBRC No. RBRC05744
Type TransgeneCartagena
Species Mus musculus
Strain name B6.Cg-Tg(Grm6-cre)7Tfur
Former Common name mGluR6-Cre, B6-Grm6Cre Tg
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Takahisa Furukawa, Institute for Protein Research, Osaka Bioscience Institute in 2012. The transgene was injected into the pronuclei of B6C3F1 fertilized eggs. The mice were crossed to C57BL/6.
Strain description mGluR6-cre transgenic mice in which cre recombinase is specifically expressed in retinal ON-type bipolar cells under the control of the upstream 9.5 kb region of mGluR6.
Colony maintenance Carrier x Noncarrier [C57BL/6NCrlCrlj]
Health Report No Data
Gene Details
Promoter mouse glutamate receptor, metabotropic 6 promoter
1 Symbol cre
Symbol name Phage P1 Cre recombinase
Chromosome UN
Common name No Data
Symbol description No Data
References No Data

Research applications Cre/loxP system,
Developmental Biology Research,
Sensorineural Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must contract an MTA with the DEPOSITOR (Osaka University).
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Furukawa, Takahisa (Osaka Bioscience Institute) Furukawa, Takahisa
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC09406, B6C3.129-Lrtm2<tm1(EUCOMM)Wtsi>/Tfur

RBRC No. RBRC09406
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6C3.129-Lrtm2<tm1(EUCOMM)Wtsi>/Tfur
Former Common name No Data
H-2 Haplotype No Data
ES cell line JM8A3.N1 [C57BL/6N-A]
Background strain Slc:B6C3F1
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol En2
Symbol name En2 SA (mouse En2 intron 2/exon 3 splice acceptor sequence)
Chromosome 6
Common name No Data
Symbol description No Data
2 Symbol Frt
Symbol name yeast FRT (flippase recombination target) site
Chromosome 6
Common name No Data
Symbol description No Data
3 Symbol Ires
Symbol name internal ribosomal entry site (EMCV)
Chromosome 6
Common name No Data
Symbol description No Data
4 Symbol Lrtm2
Symbol name leucine-rich repeats and transmembrane domains 2
Chromosome 6
Common name No Data
Symbol description No Data
5 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 6
Common name No Data
Symbol description No Data
6 Symbol loxP
Symbol name phage P1 loxP
Chromosome 6
Common name No Data
Symbol description No Data
7 Symbol poly A
Symbol name SV40 polyadenylation site
Chromosome 6
Common name No Data
Symbol description No Data
References No Data

Research applications Cre/loxP system,
FLP/frt system,
Fluorescent Proteins/lacZ System
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must contract an MTA with the DEPOSITOR (Osaka University). The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research.
Additional information
1 No Data
Depositor Furukawa, Takahisa (Institute for Protein Research, Osaka University) Furukawa, Takahisa
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC10302, C3;B6-Lrit1<tm1c(EUCOMM)Hmgu>/Tfur

RBRC No. RBRC10302
Type Targeted MutationCartagena
Species Mus musculus
Strain name C3;B6-Lrit1<tm1c(EUCOMM)Hmgu>/Tfur
Former Common name Lrit1-flox
H-2 Haplotype No Data
ES cell line JM8.N4 [C57BL/6N]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Frt
Symbol name yeast FRT (flippase recombination target) site
Chromosome 14
Common name No Data
Symbol description No Data
2 Symbol Lrit1
Symbol name leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
Chromosome 14
Common name No Data
Symbol description No Data
3 Symbol loxP
Symbol name phage P1 loxP
Chromosome 14
Common name No Data
Symbol description No Data
References No Data

Research applications Cre/loxP system,
FLP/frt system
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Cell Reports, 22, 3548-3561 (2018)
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
RECIPIENT which wants to use the BIOLOGICAL RESOURCE is requested to contact the depositor (Dr. Takahisa Furukawa) and enter into a Material Transfer Agreement with Osaka University. The RECIPIENT shall acknowledge the EUCOMM as the Provider of the ES cells to generate KO mice.
Additional information
1 No Data
Depositor Furukawa, Takahisa (Institute for Protein Research, Osaka University) Furukawa, Takahisa
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC02846, 129S6/SvEvTac-Crx<tm1Clc>

RBRC No. RBRC02846
Type Targeted MutationCartagena
Species Mus musculus
Strain name 129S6/SvEvTac-Crx<tm1Clc>
Former Common name CRX K.O.
H-2 Haplotype No Data
Background strain 129S6/SvEvTac
Appearance
1 Appearance light-bellied agouti
Genotype A/A B/B C/C
Strain development Developed by Dr. Takahisa Furukawa, Harvard Medical School in 1999.
Strain description Crx gene knockout mice. Homozygous mutant mice lack a outer segment of retinal photoreceptor.
Colony maintenance Sibling x Sibling (Homozygote x Homozygote)
Homozygous mutant mice are viable and fertile
Health Report
Gene Details
Promoter No Data
1 Symbol Crx
Symbol name cone-rod homeobox containig gene
Chromosome 7
Common name cone-rod homeobox containg gene
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome No Data
Common name neo; neomycin;
Symbol description No Data
References

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Nat. Genet., 23, 466-470 (1999).
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Furukawa, Takahisa (Osaka Bioscience Institute) Furukawa, Takahisa
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Live
Live mouse :
BRC mice in Publications
Title Journal
(PMID)
Author
Behavioral analyses of visually impaired Crx knockout mice revealed sensory compensation in exploratory activities on elevated platforms. Behav Brain Res. (2013).(24140563)
Iura Y, Udo H.

RBRC06218, C57BL/6-Susd3<tm1(KOMP)Vlcg>

RBRC No. RBRC06218
Type Targeted MutationCartagena
Species Mus musculus
Strain name C57BL/6-Susd3<tm1(KOMP)Vlcg>
Former Common name Susd3 KO, B6-Susd3 KO
H-2 Haplotype No Data
ES cell line VGB6 [C57BL/6NTac]
Background strain C57BL/6NTac
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Yoshihiro Omori and Takahisa Furukawa, Institute for Protein Research, Osaka University. The original allele and mouse were on C57BL/6 background and from the Knockout Mouse Project (KOMP) Repository.
Strain description Susd3, sushi domain containing 3 gene knockout mice. A 17004 bp region between 49,343,498-49,326,495 positions of Chromosome 13 was deleted by the insertion of ZEN-Ub1 cassette. Homozygous mutant mice are viable and fertile.
Colony maintenance Homozygote x Homozygote [or Crossing to C57BL/6NTac]
Health Report
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name SV40 polyA
Chromosome 13
Common name No Data
Symbol description No Data
2 Symbol Pgk1
Symbol name mouse PGK polyA signal
Chromosome 13
Common name No Data
Symbol description No Data
3 Symbol Susd3
Symbol name sushi domain containing 3
Chromosome 13
Common name No Data
Symbol description No Data
4 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 13
Common name No Data
Symbol description No Data
5 Symbol loxP
Symbol name phage P1 loxP
Chromosome 13
Common name No Data
Symbol description No Data
Promoter human ubiquitin C promoter
6 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 13
Common name No Data
Symbol description No Data
References No Data

Research applications Cell Biology Research,
Cre/loxP system,
Fluorescent Proteins/lacZ System
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The use of the BIOLOGICAL RESOURCE is strictly limited to academic, non-profit research institutes for academic non-profit research purposes. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must contract an MTA with the DEPOSITOR (Osaka University). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR and a mention of the Knockout Mouse Project and the KOMP Repository as the source of the original allele and mice are requested.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Furukawa, Takahisa (Institute for Protein Research, Osaka University) Furukawa, Takahisa
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC09407, B6C3.129-Zfp365<tm1(KOMP)Wtsi>/Tfur

RBRC No. RBRC09407
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6C3.129-Zfp365<tm1(KOMP)Wtsi>/Tfur
Former Common name Zfp365 KO mice
H-2 Haplotype No Data
ES cell line JM8.N4 [C57BL/6N]
Background strain Slc:B6C3F1
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol En2
Symbol name En2 SA (mouse En2 intron 2/exon 3 splice acceptor sequence)
Chromosome 10
Common name No Data
Symbol description No Data
2 Symbol Frt
Symbol name yeast FRT (flippase recombination target) site
Chromosome 10
Common name No Data
Symbol description No Data
3 Symbol Ires
Symbol name internal ribosomal entry site (EMCV)
Chromosome 10
Common name No Data
Symbol description No Data
4 Symbol Zfp365
Symbol name zinc finger protein 365
Chromosome 10
Common name No Data
Symbol description No Data
5 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 10
Common name No Data
Symbol description No Data
6 Symbol loxP
Symbol name phage P1 loxP
Chromosome 10
Common name No Data
Symbol description No Data
7 Symbol poly A
Symbol name SV40 polyadenylation site
Chromosome 10
Common name No Data
Symbol description No Data
References No Data

Research applications Cre/loxP system,
FLP/frt system,
Fluorescent Proteins/lacZ System
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must contract an MTA with the DEPOSITOR (Osaka University). The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research.
Additional information
1 No Data
Depositor Furukawa, Takahisa (Institute for Protein Research, Osaka University) Furukawa, Takahisa
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC10303, C3;B6-Lrit1<tm1b(EUCOMM)Hmgu>/Tfur

RBRC No. RBRC10303
Type Targeted MutationCartagena
Species Mus musculus
Strain name C3;B6-Lrit1<tm1b(EUCOMM)Hmgu>/Tfur
Former Common name Lrit1-gt
H-2 Haplotype No Data
ES cell line JM8.N4 [C57BL/6N]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Frt
Symbol name yeast FRT (flippase recombination target) site
Chromosome 14
Common name No Data
Symbol description No Data
2 Symbol Lrit1
Symbol name leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
Chromosome 14
Common name No Data
Symbol description No Data
3 Symbol loxP
Symbol name phage P1 loxP
Chromosome 14
Common name No Data
Symbol description No Data
References No Data

Research applications Cre/loxP system,
FLP/frt system,
Fluorescent Proteins/lacZ System
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Cell Reports, 22, 3548-3561 (2018)
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
RECIPIENT which wants to use the BIOLOGICAL RESOURCE is requested to contact the depositor (Dr. Takahisa Furukawa) and enter into a Material Transfer Agreement with Osaka University. The RECIPIENT shall acknowledge the EUCOMM as the Provider of the ES cells to generate KO mice.
Additional information
1 No Data
Depositor Furukawa, Takahisa (Institute for Protein Research, Osaka University) Furukawa, Takahisa
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC02847, 129S6/SvEvTac-Dkk3<tm1Tfur>

RBRC No. RBRC02847
Type Targeted MutationCartagena
Species Mus musculus
Strain name 129S6/SvEvTac-Dkk3<tm1Tfur>
Former Common name DKK3 K.O.
H-2 Haplotype No Data
ES cell line TC1 [129S6/SvEvTac]
Background strain 129S6/SvEvTac
Appearance
1 Appearance light-bellied agouti
Genotype A/A B/B C/C
Strain development Developed by Dr. Takahisa Furukawa, Osaka Bioscience Institute in 2007.
Strain description Dkk3 knockout mice. Homozygous mutant mice show no obvious phenotype.
Colony maintenance Sibling Mating (Homozygote x Homozygote)
Health Report
Gene Details
Promoter No Data
1 Symbol DKK3
Symbol name dickkopf homolog 3 (Xenopus laevis)
Chromosome 7
Common name dickkopf homolog 3 (Xenopus laevis)
Symbol description No Data
2 Symbol No Data
Symbol name SV40 PolyA signal
Chromosome 7
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 7
Common name neo; neomycin;
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Furukawa, Takahisa (Osaka Bioscience Institute) Furukawa, Takahisa
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging. J. Clin. Invest.124(7): 3263-73. (2014).(24911145)
Zhu Y, Demidov ON, Goh AM, Virshup DM, Lane DP, Bulavin DV.
Expression analysis of Dickkopf-related protein 3 (Dkk3) suggests its pleiotropic roles for a secretory glycoprotein in adult mouse. J. Mol. Histol. (2016).(27866302)
Inoue J, Fujita H, Bando T, Kondo Y, Kumon H, Ohuchi H.

RBRC06219, C57BL/6-Frmpd1<tm1Tfur>

RBRC No. RBRC06219
Type Targeted MutationCartagena
Species Mus musculus
Strain name C57BL/6-Frmpd1<tm1Tfur>
Former Common name Frmpd1, B6-Frmpd1 KO
H-2 Haplotype No Data
ES cell line JM8 [C57BL/6N]
Background strain C57BL/6NTac
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Yoshihiro Omori and Takahisa Furukawa, Institute for Protein Research, Osaka University in 2012. JM8 ES cells were used.
Strain description Frmpd1 gene knockout mice. Exons 3 and 4 were replaced with a PGK-neo cassette. Homozygous mutant mice are viable and fertile.
Colony maintenance Homozygote x Homozygote [or Crossing to C57BL/6NTac]
Health Report
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name SV40 poly A
Chromosome 4
Common name No Data
Symbol description No Data
2 Symbol Frmpd1
Symbol name FERM and PDZ domain containing 1
Chromosome 4
Common name No Data
Symbol description No Data
Promoter human PGK promotor
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 4
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must contract an MTA with the DEPOSITOR (Osaka University).
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Furukawa, Takahisa (Institute for Protein Research, Osaka University) Furukawa, Takahisa
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC09433, 129(Cg)-Ick<tm1.1Tfur>

RBRC No. RBRC09433
Type Targeted MutationCartagena
Species Mus musculus
Strain name 129(Cg)-Ick<tm1.1Tfur>
Former Common name ICK flox mice
H-2 Haplotype No Data
ES cell line TC1 [129S6/SvEvTac]
Background strain 129S6/SvEvTac
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Frt
Symbol name yeast FRT (flippase recombination target) site
Chromosome 9
Common name No Data
Symbol description No Data
2 Symbol Ick
Symbol name intestinal cell kinase
Chromosome 9
Common name No Data
Symbol description No Data
3 Symbol loxP
Symbol name phage P1 loxP
Chromosome 9
Common name No Data
Symbol description No Data
4 Symbol loxP
Symbol name phage P1 loxP
Chromosome 9
Common name No Data
Symbol description No Data
References No Data

Research applications Cre/loxP system,
FLP/frt system
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
EMBO J., 33(11):1227-1242(2014).
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must contract an MTA with the DEPOSITOR (Osaka University). The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Furukawa, Takahisa (Institute for Protein Research, Osaka University) Furukawa, Takahisa
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months