RBRC02422, B6.129S2-Mdk<tm1Tmu>

RBRC No. RBRC02422
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6.129S2-Mdk<tm1Tmu>
Former Common name Mdk-KO/C57BL/6J
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Mdk
Symbol name midkine
Chromosome 2
Common name Mek, MK
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome No Data
Common name neo; neomycin;
Symbol description No Data
References Am J Pathol. 2004 Nov;165(5):1603-12.
Am J Pathol. 2006 Jan;168(1):9-19.
Circulation. 2006 Oct 17;114(16):1713-20. Epub 2006 Oct 2.
J Cell Sci 2004 Oct 15;117(Pt 22):5405-15. Epub 2004 Oct 5.



Lack of the growth factor midkine enhances survival against cisplatin-induced renal damage.
Lack of the growth factor midkine enhances survival against cisplatin-induced renal damage.
Lack of the growth factor midkine enhances survival against cisplatin-induced renal damage.
Lack of the growth factor midkine enhances survival against cisplatin-induced renal damage.
Lack of the growth factor midkine enhances survival against cisplatin-induced renal damage.
Lack of the growth factor midkine enhances survival against cisplatin-induced renal damage.
Lack of the growth factor midkine enhances survival against cisplatin-induced renal damage.
Lack of the growth factor midkine enhances survival against cisplatin-induced renal damage.
Research applications Cancer Research,
Cell Biology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Muramatsu, Hisako (aichi-gakuin University) Muramatsu, Hisako
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Midkine in the mouse ventral tegmental area limits ethanol intake and Ccl2 gene expression. Genes Brain Behav.16(7): 699-708 (2017).(28398003)
Chen H, He D, Lasek AW.

RBRC02292, B6.129S2-Gcnt2<tm1Tmu>

RBRC No. RBRC02292
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6.129S2-Gcnt2<tm1Tmu>
Former Common name IGnT-KO /C57BL/6J
H-2 Haplotype No Data
ES cell line D3 [129S2/SvPas]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Gcnt2
Symbol name glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
Chromosome 13
Common name 5330430K10Rik, IGnT, IGnTA, IGnTB, IGnTC
Symbol description No Data
Promoter polyoma virus thymidine kinase gene promoter (tk promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 13
Common name neo; neomycin;
Symbol description No Data
References Mol Cell Biol. 2005 Sep;25(17):7828-38.

Abnormalities caused by carbohydrate alterations in Ibeta6-N-acetylglucosaminyltransferase-deficient mice.
Abnormalities caused by carbohydrate alterations in Ibeta6-N-acetylglucosaminyltransferase-deficient mice.
Research applications Immunology and Inflammation Research,
Internal/Organ Research,
Metabolism Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Mol. Cell. Biol., 25, 7858-7838 (2005).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Muramatsu, Hisako (aichi-gakuin University) Muramatsu, Hisako
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC02411, B6.129S2-Ptn<tm1Tmu>

RBRC No. RBRC02411
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129S2-Ptn<tm1Tmu>
Former Common name Ptn-KO/C57BL/6J
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Drs. Muramatsu H. and Muramatsu T., Nagoya University in 2001.
Strain description Pleiotrophin (PTN) knock-out mice, Ptn is a low molecular weight protein that regulates cell growth, survival and migration and other activities of responding cells. Ptn gene strongly expresses in the brain at the later mouse embryogenesis, In the human, it is known that the expression of Ptn gene is observed at the ischemic injury in various cancer.
Colony maintenance Backcross to C57BL/6 (Heterozygote x C57BL/6JJmsSlc)
Health Report
Gene Details
Promoter No Data
1 Symbol Ptn
Symbol name pleiotrophin
Chromosome 6
Common name HB-GAM, HBGF-8, heparin-binding growth factor 8, heparin-binding growth-associated molecule, Osf-1, Osf1
Symbol description No Data
Promoter polyoma virus thymidine kinase gene promoter (tk promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 6
Common name neo; neomycin;
Symbol description No Data
References Genes Cells. 2006 Dec;11(12):1405-17.


Female infertility in mice deficient in midkine and pleiotrophin, which form a distinct family of growth factors.
Female infertility in mice deficient in midkine and pleiotrophin, which form a distinct family of growth factors.
Female infertility in mice deficient in midkine and pleiotrophin, which form a distinct family of growth factors.
Female infertility in mice deficient in midkine and pleiotrophin, which form a distinct family of growth factors.
Research applications Cancer Research,
Cell Biology Research,
Neurobiology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Muramatsu, Hisako (aichi-gakuin University) Muramatsu, Hisako
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months