RBRC00216, RFM/Ms

RBRC No. RBRC00216
Type Inbred 24wks,♂
Species Mus musculus
Strain name RFM/Ms
Former Common name No Data
H-2 Haplotype No Data
Background strain RFM/MsStm
Appearance
1 Appearance albino
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name No Data
Chromosome No Data
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Shisa, Hayase (Saitama Cancer Center) Shisa, Hayase
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00217, RFM/Ms-Rb(6.15)

RBRC No. RBRC00217
Type Chromosomal Aberration
Species Mus musculus
Strain name RFM/Ms-Rb(6.15)
Former Common name No Data
H-2 Haplotype No Data
Donor strain AKR/J-Rb(6.15)1Ald
Background strain RFM/Ms
Appearance
1 Appearance albino
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Rb(6.15)1Ald
Symbol name Robertsonian translocation, Chr 6 and 15
Chromosome 15
Common name Rb1Ald
Symbol description No Data
2 Symbol Rb(6.15)1Ald
Symbol name Robertsonian translocation, Chr 6 and 15
Chromosome 6
Common name Rb1Ald
Symbol description No Data
References No Data

Research applications Genetics Research
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Shisa, Hayase (Saitama Cancer Center) Shisa, Hayase
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00222, SL/Kh

RBRC No. RBRC00222
Type Inbred
Species Mus musculus
Strain name SL/Kh
Former Common name No Data
H-2 Haplotype No Data
Background strain SL/KhStm
Appearance
1 Appearance albino
Genotype A/A, B/B, c/c
Strain development The spontaneous leukemia (SL) strain was originated from outbred Swiss albino mice, developed as a high-leukemia strain by Dr. K. Tsuchikawa in Mishima. At least 4 substrains, namely SL/Am, SL/Kh, SL/Ni, and SL/QDj had been established and maintained. SL/Kh and SL/Ni strains were deposited by Dr. Hayase Shisa, Saitama Cancer Center Institute. Pregnant females were transferred to RIKEN Tsukuba Institute, their babies were cleaned up by caesarean section, and introduced into the SPF facility.
Strain description SL/Kh is a member of the spontaneous leukemia family of mice, originated from outbred Swiss albino mice. Based on genotype analysis using microsatellite markers, SL/Kh was defined as a recombinant congenic strain between proto-SL and AKR strain mice. This strain develops pre-B lympomas by reintegration of the endogenous ecotropic MuLV provirus into a number of common integration sites, including Stat5a, Evi3, c-Myc, Stat5b, N-Myc, and others. SL/Kh is useful for an excellent multifactorial disease model.
Colony maintenance Sibling Mating
High incidence of pre-B lymphomas at early age
Health Report
Gene Details
Promoter No Data
1 Symbol Bomb1
Symbol name bone marrow pre-B 1
Chromosome 3
Common name No Data
Symbol description No Data
2 Symbol Tlsm1
Symbol name thymic lymphoma susceptible 1
Chromosome 7
Common name No Data
Symbol description No Data
References Cancer Res. 1994 Jan 15;54(2):399-402.
Cancer Res. 1994 Jan 15;54(2):403-7.
Cancer Res. 1996 Aug 15;56(16):3716-20.
Cancer Res. 1999 Jun 1;59(11):2593-5.
J Exp Med. 1994 Dec 1;180(6):2155-62.
J Natl Cancer Inst. 1987 Oct;79(4):781-7.
Lab Anim Sci. 1996 Aug;46(4):410-7.
Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8253-8. Epub 2002 Jun 4.

Research applications Cancer Research
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Shisa, Hayase (Saitama Cancer Center) Shisa, Hayase
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice. Proc. Natl. Acad. Sci. USA99: 8253-8258 (2002).(12048235)
Tatsuaki TSURUYAMA, Takuro NAKAMURA, Guang JIN, Munetaka OZEKI, Yoshihiro YAMADA, Hiroshi HIAI
Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Blood100: 238-245 (2002).(12070033)
Scott C KOGAN, Jerrold M WARD, Miriam R ANVER, Jules J BERMAN, Cory BRAYTON, Robert D CARDIFF, John S CARTER, Sherri de CORONADO, James R DOWNING, Torgny N FREDRICKSON, Diana C HAINES, Alan W HARRIS, Nancy Lee HARRIS, Hiroshi HIAI, Elaine S JAFFE, Ian C M MACLENNAN, Pier Paolo PANDOLFI, Paul K PATTENGALE, Archibald S PERKINS, R Mark SIMPSON, Mark S TUTTLE, Joanne F WONG, Herbert C 3rd MORSE
Svi3: A provirus common integration site in c-myc in SL/Kh pre-B lymphomas. Cancer Sci.94: 791-795 (2003).(12967477)
Guang JIN, Tatsuaki TSURUYAMA, Yoshihiro YAMADA, Hiroshi HIAI
Bone marrow pre-B expansion by SL/Kh-Bomb1 locus: not sufficient for lymphomagenesis. Leuk Res.32(2): 309-14 (2008).(17617450)
Hiratsuka T, Tsuruyama T, Kaszynski R, Kometani K, Minato N, Nakamura T, Tamaki K, Hiai H.
Genetic and virological predisposition to pre-B lymphomagenesis in SL/Kh. In: Mouse Models of Human Blood Cancers: Basic Research and Pre-Clinical Applications, ed. Li, S, Springer-Verlag. Springer-Verlag227-244 (2008).
Hiai H.
In vitro murine leukemia retroviral integration and structure fluctuation of target DNA. PLoS One.7(2): e31533 (2012).(22348097)
Tsuruyama T, Liu W, Yoshikawa K.
ZFP521 contributes to pre-B-cell lymphomagenesis through modulation of the pre-B-cell receptor signaling pathway. Oncogene (2015).(26522721)
Hiratsuka T, Takei Y, Ohmori R, Imai Y, Ozeki M, Tamaki K, Haga H, Nakamura T, Tsuruyama T.
STAT5A Modulates Chemokine Receptor CCR6 Expression and Enhances Pre-B Cell Growth in a CCL20-Dependent Manner. J. Cell Biochem. (2016).(27018255)
Tsuruyama T, Hiratsuka T, Wulamujiang A, Nakamura T.
DNA insertion mutations can be predicted by a periodic probability function. arXiv (2017).
Tatsuaki Tsuruyama.

RBRC00224, SL/Ni

RBRC No. RBRC00224
Type Inbred wks
Species Mus musculus
Strain name SL/Ni
Former Common name No Data
H-2 Haplotype q
Background strain SL/NiStm
Appearance
1 Appearance albino
Genotype No Data
Strain development This strain originated from outbred Swiss mice, and the four substrains of SL family had been established at Kyushyu University. SL/Kh and SL/Ni strains were deposited by Dr. Hayase Shisa, Saitama Cancer Center Institute.
Pregnant females were transferred to RIKEN Tsukuba Institute, their babies were cleaned up by Caesarean section, and introduced into the SPF facility.
Strain description This strain has been established in Japan. Outbred Swiss mouse origin. High incidence of lymphoma was found in SL/Am, and not in SL/Ni.
There are four substrains of SL family, DL/QDj, SL/Am, SL/Ni and SL/Kh. The SL/Ni and SL/Am strains are almost identical and share similar genetic background with the proto-SL strain.
Colony maintenance The mice are maintained by sister-brother mating. Females and males in the same litter are recommended to mate just after weaning. When females and males from the different litters are used, males of 8-12 weeks old and females of 4-8 weeks old breed well.
Health Report
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name No Data
Chromosome No Data
Common name No Data
Symbol description No Data
References Cancer Res. 1994 Jan 15;54(2):399-402.
Cancer Res. 1994 Jan 15;54(2):403-7.
Cancer Res. 1996 Aug 15;56(16):3716-20.
Cancer Res. 1999 Jun 1;59(11):2593-5.
J Exp Med. 1994 Dec 1;180(6):2155-62.
J Natl Cancer Inst. 1987 Oct;79(4):781-7.
Lab Anim Sci. 1996 Aug;46(4):410-7.
Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8253-8. Epub 2002 Jun 4.

Abnormal bone marrow B-cell differentiation in pre-B lymphoma-prone SL/Kh mice.
Abnormal bone marrow B-cell differentiation in pre-B lymphoma-prone SL/Kh mice.
Abnormal bone marrow B-cell differentiation in pre-B lymphoma-prone SL/Kh mice.
Abnormal bone marrow B-cell differentiation in pre-B lymphoma-prone SL/Kh mice.
Abnormal bone marrow B-cell differentiation in pre-B lymphoma-prone SL/Kh mice.
Abnormal bone marrow B-cell differentiation in pre-B lymphoma-prone SL/Kh mice.
Abnormal bone marrow B-cell differentiation in pre-B lymphoma-prone SL/Kh mice.
Abnormal bone marrow B-cell differentiation in pre-B lymphoma-prone SL/Kh mice.
Research applications Cancer Research
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Shisa, Hayase (Saitama Cancer Center) Shisa, Hayase
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00692, BALB/cAcc/Stm-nu

RBRC No. RBRC00692
Type Spontaneous Mutation
Species Mus musculus
Strain name BALB/cAcc/Stm-nu
Former Common name No Data
H-2 Haplotype No Data
Background strain BALB/c
Appearance
1 Appearance albino
Genotype No Data
Strain description No Data
Health Report
BRC facility Health Report in the last year and a half

Examination Date Room Rack
Nov 11, 2019 2-検 G
Sep 9, 2019 2-検 G
Jul 8, 2019 2-検 G
May 7, 2019 2-検 G
Mar 11, 2019 2-検 G
Jan 15, 2019 2-検 G
Nov 12, 2018 2-検 G
Sep 10, 2018 2-検 G

Gene Details
Promoter No Data
1 Symbol Foxn1
Symbol name forkhead box N1
Chromosome 11
Common name D11Bhm185e, Hfh11, whn
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Shisa, Hayase (Saitama Cancer Center) Shisa, Hayase
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

Live
Live mouse :

RBRC00011, AKR/Ms-Rb(6.15)

RBRC No. RBRC00011
Type Chromosomal Aberration 24wks,♂
Species Mus musculus
Strain name AKR/Ms-Rb(6.15)
Former Common name No Data
H-2 Haplotype k
Donor strain AKR-Rb(6.15)1Ald
Background strain AKR/Ms
Appearance
1 Appearance albino
Genotype a/a B/B c/c
Strain development AKR-Rb(6.15)1Ald/StmBrc. This strain have a Robertsonian translocation involving Chr 6 and Chr 15, the 1st chromosome anomaly from Dr. Adler Leonard’s lab. This strain is useful as genetic research tools.
Strain description Chromosomal abbreviation originally arose in AKR/J at Dr. Adler Leonard’s lab in 1996. The AKR/Ms-Rb(6.15) strain was generated by backcrossed to AKR/Ms by Dr. Izumi Shisa at Saitama Cancer Institute.
Colony maintenance Sibling Mating (Homozygote x Homozygote)
Health Report
Gene Details
Promoter No Data
1 Symbol Rb(6.15)1Ald
Symbol name Robertsonian translocation, Chr 6 and 15
Chromosome 15
Common name Rb1Ald
Symbol description No Data
2 Symbol Rb(6.15)1Ald
Symbol name Robertsonian translocation, Chr 6 and 15
Chromosome 6
Common name Rb1Ald
Symbol description No Data
References Cancer Genet Cytogenet. 1983 Jun;9(2):151-66.

Trisomy of chromosome 6.15 is not necessary for proliferation of AKR(Rb6.15)1Ald lymphoma cells.
Research applications Cancer Research,
Genetics Research
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Shisa, Hayase (Saitama Cancer Center) Shisa, Hayase
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00693, AKR/J-nu str

RBRC No. RBRC00693
Type Spontaneous Mutation
Species Mus musculus
Strain name AKR/J-nustr
Former Common name No Data
H-2 Haplotype k
Background strain No Data
Appearance
1 Appearance albino
Genotype No Data
2 Appearance albino nude
Genotype nu
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Foxn1
Symbol name forkhead box N1
Chromosome 11
Common name D11Bhm185e, Hfh11, whn
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Shisa, Hayase (Saitama Cancer Center) Shisa, Hayase
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00012, AKR/Ms-Rb(6.15)- Foxn1 nu

RBRC No. RBRC00012
Type Spontaneous Mutation Congenic 8wks,♂
Species Mus musculus
Strain name AKR/Ms-Rb(6.15)-Foxn1nu
Former Common name No Data
H-2 Haplotype No Data
Background strain AKR
Appearance
1 Appearance albino, hairless albino
Genotype nu/+, Rb
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Foxn1
Symbol name forkhead box N1
Chromosome 11
Common name D11Bhm185e, Hfh11, whn
Symbol description No Data
2 Symbol Rb(6.15)1Ald
Symbol name Robertsonian translocation, Chr 6 and 15
Chromosome 15
Common name Rb1Ald
Symbol description No Data
3 Symbol Rb(6.15)1Ald
Symbol name Robertsonian translocation, Chr 6 and 15
Chromosome 6
Common name Rb1Ald
Symbol description No Data
References Cancer Genet Cytogenet. 1983 Jun;9(2):151-66.

Trisomy of chromosome 6.15 is not necessary for proliferation of AKR(Rb6.15)1Ald lymphoma cells.
Research applications Cancer Research
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Shisa, Hayase (Saitama Cancer Center) Shisa, Hayase
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00034, C57BL/10-mt<ddY>/StmRbrc

RBRC No. RBRC00034
Type Spontaneous Mutation
Species Mus musculus
Strain name C57BL/10-mt<ddY>/StmRbrc
Former Common name B10mtJ
H-2 Haplotype No Data
Background strain C57BL/10
Appearance
1 Appearance black
Genotype No Data
Strain description mitochondrial gene mutation
Health Report No Data
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name No Data
Chromosome No Data
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Shisa, Hayase (Saitama Cancer Center) Shisa, Hayase
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00093, C3H-fBi

RBRC No. RBRC00093
Type Inbred
Species Mus musculus
Strain name C3H-fBi
Former Common name No Data
H-2 Haplotype k
Background strain C3H
Appearance
1 Appearance agouti, retinal degeneration
Genotype A/A Pde6brd1/Pde6brd1
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Pde6b
Symbol name phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Chromosome 5
Common name nmf137, Pdeb, r, rd, rd10
Symbol description No Data
References No Data

Research applications Sensorineural Research
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Shisa, Hayase (Saitama Cancer Center) Shisa, Hayase
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months