RBRC00765, INAD

RBRC No. RBRC00765
Type Spontaneous Mutation
Species Mus musculus
Strain name INAD
Former Common name infantile neuroaxonal dystrophy: INAD
H-2 Haplotype No Data
Background strain C57BL/6
Appearance
1 Appearance black
Genotype (a/a B/B C/C)
Strain development Discovered in a C57BL/6 breeding colony. Developed by Dr. Yoshibumi Matsushima, Saitama Cancer Center in 2005.
Strain description The spontaneous mutation that was discovered in a C57BL/6 breeding colony. Homozygous mutant mice exhibit the incoordinated limbs and lean body in the lower half of the body, and die from 4 to 5 weeks after birth. In these mice, a neurodystrophic change appearing as spheroid bodies in central and peripheral nervous system is observed. This strain is useful as a mouse model for infantile neuroaxonal dystrophy (INAD).
Colony maintenance Sibling Mating (Heterozygote x Heterozygote) or Transplant-Cross-Intercross (maintenace by ovary transplantation, Homozygote x Heterozygote)
Homozygous mutant mice die before sexual maturity.
Health Report
Gene Details
Promoter No Data
1 Symbol inad
Symbol name infantile neuroaxonal dystrophy
Chromosome 1
Common name infantile neuroaxonal dystrophy
Symbol description No Data
References Mamm Genome. 2005 Feb;16(2):73-8.

A new mouse model for infantile neuroaxonal dystrophy, inad mouse, maps to mouse chromosome 1.
Research applications Mouse Models for Human Disease
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 Mouse of the Month Mar 2005
Depositor Matsushima, Yoshibumi (Saitama Cancer Center) Matsushima, Yoshibumi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC06419, KOR1.Cg-Dms

RBRC No. RBRC06419
Type Spontaneous Mutation
Species Mus musculus
Strain name KOR1.Cg-Dms
Former Common name KOR.DMS, KOR1-Dms
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Yoshibumi Matsushima, Saitama Cancer Center, Research Institute for Clinical Oncology.
Strain description Diabetes Mellitus Saitama, DMS. Spontaneous mutation arose in NC/Jic x KOR1 F2 generations. Heterozygous mutant mice show type 2 diabetes. Homozygous mutant mice show lethal neonatal diabetes. Under investigation (details unknown). AKR background (semicongenic) (RBRC06413), C57BL/6 background (semicongenic) (RBRC06414), BALB/c background (semicongenic) (RBRC06415), C3H background (semicongenic) (RBRC06416), DBA/2 background (semicongenic) (RBRC06417), JF1 background (semicongenic) (RBRC06418), KOR1 background(semicongenic) (RBRC06419), NC background(semicongenic) (RBRC06420).
Colony maintenance Heterozygote x Wild-type [or Crossing to KOR1/Stm (RBRC00427)]
Health Report
Gene Details
Promoter No Data
1 Symbol Insr
Symbol name insulin receptor
Chromosome 8
Common name No Data
Symbol description No Data
References No Data

Research applications Diabetes and Obesity Research,
Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
後日指定。(will be announced.)
For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR.
Additional information
1 No Data
Depositor Matsushima, Yoshibumi (Saitama Cancer Center) Matsushima, Yoshibumi
Strain Status /
Availability
(Expected delivery)


Live
Live mouse :

RBRC00849, B6;KOR1-Traf3ip2<adjm>

RBRC No. RBRC00849
Type Spontaneous Mutation Congenic 4wks,♂
Species Mus musculus
Strain name B6;KOR1-Traf3ip2<adjm>
Former Common name B6.NAD
H-2 Haplotype No Data
Donor strain NAD
Background strain C57BL/6JJcl
Appearance
1 Appearance black
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Traf3ip2
Symbol name TRAF3 interacting protein 2
Chromosome 10
Common name No Data
Symbol description No Data
References

Research applications Dermatology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Immunol., 185, 2340-2349 (2010). Immunopharmacol Immunotoxicol, 37, 202-206 (2015).
Additional information
1 No Data
Depositor Matsushima, Yoshibumi (Saitama Cancer Center) Matsushima, Yoshibumi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC06420, NC.Cg-Dms

RBRC No. RBRC06420
Type Spontaneous Mutation
Species Mus musculus
Strain name NC.Cg-Dms
Former Common name NC.DMS, NC-Dms
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Yoshibumi Matsushima, Saitama Cancer Center, Research Institute for Clinical Oncology.
Strain description Diabetes Mellitus Saitama, DMS. Spontaneous mutation arose in NC/Jic x KOR1 F2 generations. Heterozygous mutant mice show type 2 diabetes. Homozygous mutant mice show lethal neonatal diabetes. Under investigation (details unknown). AKR background (semicongenic) (RBRC06413), C57BL/6 background (semicongenic) (RBRC06414), BALB/c background (semicongenic) (RBRC06415), C3H background (semicongenic) (RBRC06416), DBA/2 background (semicongenic) (RBRC06417), JF1 background (semicongenic) (RBRC06418), KOR1 background(semicongenic) (RBRC06419), NC background(semicongenic) (RBRC06420).
Colony maintenance Heterozygote x Wild-type [or Crossing to NC/NgaSlc]
Health Report
Gene Details
Promoter No Data
1 Symbol Insr
Symbol name insulin receptor
Chromosome 8
Common name No Data
Symbol description No Data
References No Data

Research applications Diabetes and Obesity Research,
Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
後日指定。(will be announced.)
For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR.
Additional information
1 No Data
Depositor Matsushima, Yoshibumi (Saitama Cancer Center) Matsushima, Yoshibumi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

Live
Live mouse :

RBRC00948, C.KOR1-Traf3ip2<adjm>

RBRC No. RBRC00948
Type Spontaneous Mutation Congenic
Species Mus musculus
Strain name C.KOR1-Traf3ip2<adjm>
Former Common name atopic dermatitis; BALB/c.NAD
H-2 Haplotype No Data
Donor strain NAD
Background strain BALB/cAJcl
Appearance
1 Appearance albino
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Traf3ip2
Symbol name TRAF3 interacting protein 2
Chromosome 10
Common name No Data
Symbol description No Data
References

Research applications Dermatology Research
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Matsushima, Yoshibumi (Saitama Cancer Center) Matsushima, Yoshibumi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC06422, BALB/c-Scn1a<+/->

RBRC No. RBRC06422
Type Spontaneous Mutation
Species Mus musculus
Strain name BALB/c-Scn1a<+/->
Former Common name C.Dravet, BALB-Scn1a
H-2 Haplotype No Data
Background strain BALB/cCrSlc
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Yoshibumi Matsushima, Saitama Cancer Center, Research Institute for Clinical Oncology.
Strain description Scn1a spontaneous mutant (Dravet syndrome) mice arose in BALB/c. Heterozygous mice show heat-induced epileptic seizure. Homozygous mutant mice show severe myoclonic epilepsy in infancy, and die at around 3 weeks old. Under investigation. BALB/cCrSlc background (semicongenic) (RBRC06422).
Colony maintenance Heterozygote x Heterozygote [or Crossing to BALB/cCrSlc]
Health Report
Gene Details
Promoter No Data
1 Symbol Scn1a
Symbol name sodium channel, voltage-gated, type I, alpha
Chromosome 2
Common name No Data
Symbol description No Data
References No Data

Research applications Mouse Models for Human Disease,
Neurobiology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
後日指定。(will be announced.)
For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR.
Additional information
1 No Data
Depositor Matsushima, Yoshibumi (Saitama Cancer Center) Matsushima, Yoshibumi
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC00982, A.KOR1-Traf3ip2<adjm>

RBRC No. RBRC00982
Type Spontaneous Mutation Congenic wks
Species Mus musculus
Strain name A.KOR1-Traf3ip2<adjm>
Former Common name atopic dermatitis; A.NAD
H-2 Haplotype No Data
Donor strain NAD
Background strain A
Appearance
1 Appearance albino
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Traf3ip2
Symbol name TRAF3 interacting protein 2
Chromosome 10
Common name No Data
Symbol description No Data
References

Research applications Immunology and Inflammation Research
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Matsushima, Yoshibumi (Saitama Cancer Center) Matsushima, Yoshibumi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC06424, SMD

RBRC No. RBRC06424
Type Spontaneous Mutation
Species Mus musculus
Strain name SMD
Former Common name SMD, BALB-smd
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Yoshibumi Matsushima, Saitama Cancer Center, Research Institute for Clinical Oncology. BALB/cNCrSlc background (semicongenic).
Strain description Spontaneous muscular dystrophy (SMD) mice. Autosomal recessive mutant arose in BALB/c. Homozygous mutant mice show muscular dystrophy, survive for up to about 2-5 months old. Under investigation.
Colony maintenance Heterozygote x Heterozygote [or Homozygote (female) x Heterozygote (male)(Transplant-Cross-Intercross)][or Crossing to BALB/cCrSlc]
Health Report
Gene Details
Promoter No Data
1 Symbol smd
Symbol name spontaneous muscular dystrophy
Chromosome UN
Common name No Data
Symbol description No Data
References No Data

Research applications Mouse Models for Human Disease,
Neurobiology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
後日指定。(will be announced.)
For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR.
Additional information
1 No Data
Depositor Matsushima, Yoshibumi (Saitama Cancer Center) Matsushima, Yoshibumi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC00052, SHL

RBRC No. RBRC00052
Type Wild-derived Inbred and Spontaneous Mutation 4wks
Species Mus musculus molossinus
Strain name SHL
Former Common name hyperlipidemia
H-2 Haplotype No Data
Background strain KOR [Mus musculus molossinus]
Appearance
1 Appearance white belly agouti
Genotype No Data
Strain development Spontaneous mutation arose in KOR wild-derived mouse colony. The mutant mice were maintained by sibling mating.
Strain description SHL, spontaneously hyperlipidemia mutant mice. Spontaneous mutation arose in KOR mouse colony derived from Japanese wild-mice (Mus musculus molossius). Homozygous mutant mice show increased circulating cholesterol level. Homozygous mutant mice are viable and fertile (before onset of xanthoma). Females of homozygote show lower reproductive performance.
Health Report
Gene Details
Promoter No Data
1 Symbol Apoe
Symbol name apolipoprotein E
Chromosome 7
Common name Apoe
Symbol description No Data
References The Lipid, 13, 318-324 (2002).
J Atheroscler Thromb. 2001;8(3):71-9.
Mamm Genome. 1999 Apr;10(4):352-7.

Research applications Hematological Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT shall use the BIOLOGICAL RESOURCE only for academic research for the purpose of publishing the research results.
Additional information
1 Mouse of the Month Jan 2006
Depositor Matsushima, Yoshibumi (Saitama Cancer Center) Matsushima, Yoshibumi
Strain Status /
Availability
(Expected delivery)


Live
Live mouse :

RBRC01004, SL/Kh-Tlsm1

RBRC No. RBRC01004
Type Spontaneous Mutation wks
Species Mus musculus
Strain name SL/Kh-Tlsm1
Former Common name No Data
H-2 Haplotype No Data
Donor strain AKR/Ms
Background strain SL/Kh
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Bomb1
Symbol name bone marrow pre-B 1
Chromosome 3
Common name No Data
Symbol description No Data
2 Symbol Tlsm1
Symbol name thymic lymphoma susceptible 1
Chromosome 7
Common name No Data
Symbol description No Data
3 Symbol Tlsm1
Symbol name thymic lymphoma susceptible 1
Chromosome 7
Common name No Data
Symbol description No Data
References J Exp Med. 1994 Dec 1;180(6):2155-62.

T lymphomagenesis is determined by a dominant host gene thymic lymphoma susceptible mouse-1 (TLSM-1) in mouse models.
Research applications No Data
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Matsushima, Yoshibumi (Saitama Cancer Center) Matsushima, Yoshibumi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months