RBRC00376, ATX/Nem-Cts

RBRC No. RBRC00376
Type Spontaneous Mutation
Species Mus musculus
Strain name ATX/Nem-Cts
Former Common name No Data
H-2 Haplotype No Data
Donor strain CTS
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Cts
Symbol name cataract and small eye
Chromosome 10
Common name No Data
Symbol description No Data
References Anat. Rec., 178, 380, (1974).
Jpn. J. Genet., 53, 147, (1978).

Research applications Sensorineural Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
Additional information
1 No Data
Depositor Oda, Senichi (Nagoya University) Oda, Senichi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00377, C3H/HeNem-ruf/+

RBRC No. RBRC00377
Type Spontaneous Mutation
Species Mus musculus
Strain name C3H/HeNem-ruf/+
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol ruf
Symbol name rough fur
Chromosome 9
Common name No Data
Symbol description No Data
References Exp Anim. 2001 Apr;50(2):179-82.

Research applications Cell Biology Research,
Dermatology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Oda, Senichi (Nagoya University) Oda, Senichi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00379, B6.Cg-Hm+/+Reln<rl>/NemOdaRbrc

RBRC No. RBRC00379
Type Spontaneous Mutation wks
Species Mus musculus
Strain name B6.Cg-Hm+/+Reln<rl>/NemOdaRbrc
Former Common name C57BL/6-Hm/+-rl/+
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Dr. Sen-ichi Oda, Nagoya University. This strain was generated by crossbreeding heterozygotic reeler (C57BL/6-rl) and hammer-toe (C57BL/6-Hm) mutants.
Strain description B6.Cg-Hm+/+Reln<rl>. This strain was generated by crossbreeding heterozygotic reeler (Reln<rl>) and hammer-toe (Hm) mutant mice to facilitate distinguishing between heterozygous reeler mice (rl/+) and wildtype. The Hammer-toe semidominant gene is located near reeler locus on the homologous chromosome. The reeler mutation causes an abnormal pattern in the layering of neurons in the neocortex and the cerebellum. The reeler homozygous (rl/rl) mutant mice show impaired motor coordination, tremors and ataxia. The hammer-toe homozygous (Hm/Hm) mutant mice show markedly-flexed digits having a fusion of the interdigital tissues, whereas in Hm heterozygotes (Hm/+) the degree of flexion is not so severe compared to those of homozygotes.
Colony maintenance Sibling mating (Hm +/+ rl x Hm +/+ rl)
Reeler homozygous mutant mice show impaired motor coordination, tremors and ataxia, and die by 4 weeks of age. Hammer toe homozygous mutant mice are viable and fertile.
Health Report
Gene Details
Promoter No Data
1 Symbol Hm
Symbol name hammer toe
Chromosome 5
Common name No Data
Symbol description No Data
2 Symbol Reln
Symbol name reelin
Chromosome 5
Common name No Data
Symbol description No Data
References Anat Embryol (Berl). 1993 Oct;188(4):317-29.

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
Additional information
1 No Data
Depositor Oda, Senichi (Nagoya University) Oda, Senichi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00380, C57BL/6By-Sd/+-Re

RBRC No. RBRC00380
Type Spontaneous Mutation
Species Mus musculus
Strain name C57BL/6By-Sd/+-Re
Former Common name No Data
H-2 Haplotype No Data
Donor strain C57BL/6By
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Krt25
Symbol name keratin 25
Chromosome 11
Common name No Data
Symbol description No Data
2 Symbol Etn2
Symbol name early transposon element 2; short Danforth
Chromosome 2
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
Depositor Oda, Senichi (Nagoya University) Oda, Senichi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00382, DLB/Oda

RBRC No. RBRC00382
Type Spontaneous Mutation wks
Species Mus musculus
Strain name DLB/Oda
Former Common name DSL-dl-se/+
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
BRC facility Health Report in the last year and a half

Examination Date Room Rack
May 13, 2008 2-検 H
May 12, 2008 2-検 H
Mar 3, 2008 2-検 H
Jan 7, 2008 2-検 H
Oct 29, 2007 2-検 H
Jul 2, 2007 2-検 H
May 8, 2007 2-検 H
May 7, 2007 2-検 H

Gene Details
Promoter No Data
1 Symbol Bmp5
Symbol name bone morphogenetic protein 5
Chromosome 9
Common name No Data
Symbol description No Data
2 Symbol Myo5a
Symbol name myosin Va
Chromosome 9
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Additional information
1 No Data
Depositor Oda, Senichi (Nagoya University) Oda, Senichi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00383, DSO/Oda

RBRC No. RBRC00383
Type Spontaneous Mutation
Species Mus musculus
Strain name DSO/Oda
Former Common name d30-d30/+-se/+
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Bmp5
Symbol name bone morphogenetic protein 5
Chromosome 9
Common name No Data
Symbol description No Data
2 Symbol Myo5a
Symbol name myosin Va
Chromosome 9
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Additional information
1 No Data
Depositor Oda, Senichi (Nagoya University) Oda, Senichi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00384, JOG/Oda

RBRC No. RBRC00384
Type Spontaneous Mutation wks
Species Mus musculus
Strain name JOG/Oda
Former Common name m98
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Atp2b2
Symbol name ATPase, Ca++ transporting, plasma membrane 2
Chromosome 6
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Additional information
1 No Data
Depositor Oda, Senichi (Nagoya University) Oda, Senichi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00385, ITO3/Oda

RBRC No. RBRC00385
Type Spontaneous Mutation wks
Species Mus musculus
Strain name ITO3/Oda
Former Common name ITO/Nem
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Tyr
Symbol name tyrosinase
Chromosome 7
Common name skc35
Symbol description No Data
2 Symbol oen
Symbol name open eyelid Nagoya
Chromosome UN
Common name open eyelid Nagoya
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Additional information
1 No Data
Depositor Oda, Senichi (Nagoya University) Oda, Senichi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00386, KDT/Nem -Lb/+ -p/+

RBRC No. RBRC00386
Type Spontaneous Mutation
Species Mus musculus
Strain name KDT/Nem -Lb/+ -p/+
Former Common name No Data
H-2 Haplotype No Data
Donor strain KSB x DBA/MaMs-ce-fa
Background strain No Data
Appearance
1 Appearance black and white patches
Genotype a/a B/B s/s
2 Appearance pink eyed dilution and white patches
Genotype a/a B/B s/s p/p
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol T
Symbol name brachyury
Chromosome 17
Common name No Data
Symbol description No Data
2 Symbol Oca2
Symbol name oculocutaneous albinism II
Chromosome 7
Common name D7H15S12, D7H15S12, pink-eyed dilution
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Oda, Senichi (Nagoya University) Oda, Senichi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00388, PROD-Cacna1a<tg-rol>/NemOdaRbrc

RBRC No. RBRC00388
Type Spontaneous Mutation wks
Species Mus musculus
Strain name PROD-Cacna1a<tg-rol>/NemOdaRbrc
Former Common name PROD-rol/+
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance agouti with white spot
Genotype A/A B/? C/C s/s
Strain development Developed by Dr. Sen-ichi Oda, Nagoya University. Cacna1a<tg-rol> arose spontaneously in descendants of (SIII x C57BL/6)F1 in 1969.
Strain description Rolling mouse Nagoya, PROD-Cacna1a<tg-rol>/NemOdaRbrc. Cacna1a gene is a voltage-gated pore-forming membrane protein, mediates Ca2+ influx across presynaptic and somatodendritic membranes, thereby triggering fast neurotransmitter release and other key neuronal responses. Homozygous mutant mice exhibit a severe ataxia, episodic dyskinesia, and cerebellar atrophy.
Colony maintenance Homozygous mutant mice are identifiable between 10 and 14 days old by a creeping or rolling gait.
homozygous females are fertile but do not breed well.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Cacna1a
Symbol name calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Chromosome 8
Common name alpha1A, Cacnl1a4, Ccha1a, EA2, MHP1, nmf352, SCA6
Symbol description No Data
References Biomed. Res., 1, 88-90 (1980).
Genetic Approches to Developmental Neurobiology (TSUKADA Yasuzo, ed), University of Tokyo Press, Tokyo, pp. 171-181 (1982).
Jpn. J. Genet., 56, 295-299 (1981).
Dev Psychobiol. 1986 Jan;19(1):67-77.
J Neurosci. 2000 Aug 1;20(15):5654-62.
Neurosci Lett. 1999 Apr 30;266(1):49-52.
Neurosci Res. 1988 Apr;5(4):316-24.

Research applications Developmental Biology Research,
Genetics Research,
Neurobiology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Oda, Senichi (Nagoya University) Oda, Senichi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation. Blood.107(3): 1078-84 (2006).(16219795)
Goriely S, Molle C, Nguyen M, Albarani V, Haddou NO, Lin R, De Wit D, Flamand V, Willems F, Goldman M.
Spatial learning deficit in aged heterozygous Cav2.1 channel mutant mice, rolling mouse Nagoya. Exp Gerontol.44(4): 274-9 (2009).(19073246)
Takahashi E, Niimi K.
Hypoalgesic behaviors of P/Q-type voltage-gated Ca2+ channel mutant mouse, rolling mouse Nagoya. Neuroscience.160(1): 165-73 (2009).(19248821)
Fukumoto N, Obama Y, Kitamura N, Niimi K, Takahashi E, Itakura C, Shibuya I.
Motor coordination impairment in aged heterozygous rolling Nagoya, Cav2.1 mutant mice. Brain Res.1279 16983: (2009).(19446536)
Takahashi E, Niimi K, Itakura C.
Age-related spatial and nonspatial short-term memory in Cav2.1alpha1 mutant mice, Rolling Nagoya. Behav Brain Res.204(1): 241-5 (2009).(19467269)
Takahashi E, Niimi K, Itakura C.
Interaction between Ca(v)2.1alpha (1) and CaMKII in Ca (v)2.1alpha (1) mutant mice, Rolling Nagoya. J Mol Neurosci.41(2): 223-9 (2010).(19609731)
Takahashi E, Niimi K, Itakura C.
Ca(2+) channel currents in dorsal root ganglion neurons of P/Q-type voltage-gated Ca(2+) channel mutant mouse, rolling mouse Nagoya. Neurosci Res.73(3): 199-206 (2012).(22575052)
Fukumoto N, Kitamura N, Niimi K, Takahashi E, Itakura C, Shibuya I.
Analysis of ischemic neuronal injury in Cav2.1 channel alpha 1 subunit mutant mice. Biochem Biophys Res Commun. (2013).(23545255)
Tian X, Zhou Y, Gao L, He G, Jiang W, Li W, Takahashi E.
Blockade of Cav2.1-mediated NMDA receptor signaling disrupts conditioned fear extinction. Behav Brain Res. (2013).(24177210)
Niimi K, Han Y, Zhou Y, Yoshimoto T, Dai F, Teng X, Tian X, Li W, Takahashi E.
Analysis of the protective effects of the α2/δ subunit of voltage-gated Ca2+ channels in brain injury. Brain Res. (2016).(27840189)
Kim TY, Niimi K, Takahashi E.