RBRC06388, B6;129P2-Fbxl21<tm1Kei>

RBRC No. RBRC06388
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129P2-Fbxl21<tm1Kei>
Former Common name Fbxl21 KO, B6-bxl21 KO
H-2 Haplotype No Data
ES cell line E14 [129P2/OlaHsd]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Keiichi Nakayama, Medical Institute of Bioregulation, Kyushu University. E14 ES cells were used. The mutant mice were crossed to C57BL/6J (N7 generations).
Strain description Fbxl21 gene knockout mice. Exons 4 and 5 were replaced with an IRES-lacZ/neo cassette.
Colony maintenance Homozygote x Homozygote [or Crossing to C57BL/6JJcl]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name SV40 polyA signal
Chromosome 13
Common name No Data
Symbol description No Data
2 Symbol Fbxl21
Symbol name F-box and leucine-rich repeat protein 21
Chromosome 13
Common name No Data
Symbol description No Data
3 Symbol IRES
Symbol name internal ribosomal entry site (EMCV)
Chromosome 13
Common name No Data
Symbol description No Data
4 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 13
Common name No Data
Symbol description No Data
5 Symbol loxP
Symbol name phage P1 loxP
Chromosome 13
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
6 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 13
Common name No Data
Symbol description No Data
References

Research applications Cre/loxP system,
Fluorescent Proteins/lacZ System,
Metabolism Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 Lab HP
Depositor Nakayama, Keiichi (Medical institute of bioregulation, Kyushu University) Nakayama, Keiichi
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC06404, B6;129P2-Cdkn1c<tm1.1(Cdkn1b*)Kei>

RBRC No. RBRC06404
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129P2-Cdkn1c<tm1.1(Cdkn1b*)Kei>
Former Common name p57/p27KI, B6-Cdkn1c/Cdkn1b KI
H-2 Haplotype No Data
ES cell line E14 [129P2/OlaHsd]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Keiichi Nakayama, Medical Institute of Bioregulation, Kyushu University. E14 ES cells were used. The mutant mice were crossed to C57BL/6J over 5 times.
Strain description p57 gene p27 knockin mice. Intron 2 of p57 was replaced with a p27 cDNA (p57<p27KI> type). Paternal imprinting gene.
Colony maintenance Heterozygote (male) x Wild-type (female) [C57BL/6JJcl]
Health Report
Gene Details
Promoter No Data
1 Symbol Cdkn1c
Symbol name cyclin-dependent kinase inhibitor 1C (P57)
Chromosome 7
Common name No Data
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 7
Common name No Data
Symbol description No Data
References

Research applications Cell Biology Research,
Cre/loxP system
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Nakayama, Keiichi (Medical institute of bioregulation, Kyushu University) Nakayama, Keiichi
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC06389, B6;129P2-Fbxl3<tm1Kei>

RBRC No. RBRC06389
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129P2-Fbxl3<tm1Kei>
Former Common name Fbxl3 KO, B6-Fbxl3 KO
H-2 Haplotype No Data
ES cell line E14 [129P2/OlaHsd]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Keiichi Nakayama, Medical Institute of Bioregulation, Kyushu University. E14 ES cells were used. The mutant mice were crossed to C57BL/6J (N7 generations).
Strain description Fbxl3 gene knockout mice. Exons 2 and 3 were replaced with an IRES-lacZ/neo cassette.
Colony maintenance Homozygote x Homozygote [or Crossing to C57BL/6JJcl]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name SV40 polyA signal
Chromosome 14
Common name No Data
Symbol description No Data
2 Symbol Fbxl3
Symbol name F-box and leucine-rich repeat protein 3
Chromosome 14
Common name No Data
Symbol description No Data
3 Symbol IRES
Symbol name internal ribosomal entry site (EMCV)
Chromosome 14
Common name No Data
Symbol description No Data
4 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 14
Common name No Data
Symbol description No Data
5 Symbol loxP
Symbol name phage P1 loxP
Chromosome 14
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
6 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 14
Common name No Data
Symbol description No Data
References

Research applications Cre/loxP system,
Fluorescent Proteins/lacZ System,
Metabolism Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 Lab HP
Depositor Nakayama, Keiichi (Medical institute of bioregulation, Kyushu University) Nakayama, Keiichi
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC09758, B6;129P2-Chd8<tm1Kei>

RBRC No. RBRC09758
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129P2-Chd8<tm1Kei>
Former Common name Chd8/Duplin KO
H-2 Haplotype No Data
ES cell line E14 [129P2/OlaHsd]
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Deposited by Keiichi Nakayama, Medical Institute of Bioregulation, Kyusyu University in 2016. E14(129P2/OlaHsd) ES cell line was used. Mixed genetic background in C57BL/6 and 129P2.
Strain description Chd8 (chromodomain helicase DNA binding protein 8) knockout mice. Homozygous mutants are lethal. Heterozygous mutant displays autistic like behavior. All exons were replaced by loxP-neo cassette. Mouse strain carrying deletion of only long isoform of Chd8 (Chd8l) is available as RBRC09759.
Health Report
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name SV40 PolyA signal
Chromosome 14
Common name No Data
Symbol description No Data
2 Symbol Chd8
Symbol name chromodomain helicase DNA binding protein 8
Chromosome 14
Common name No Data
Symbol description No Data
3 Symbol loxP
Symbol name phage P1 loxP
Chromosome 14
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
4 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 14
Common name No Data
Symbol description No Data
References No Data

Research applications Cre/loxP system,
Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 Mouse of the Month Nov 2018
2 Genotyping protocol <PCR>
Depositor Nakayama, Keiichi (Medical institute of bioregulation, Kyushu University) Nakayama, Keiichi
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC06390, B6;129P2-Fbxl5<tm2.1Kei>

RBRC No. RBRC06390
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129P2-Fbxl5<tm2.1Kei>
Former Common name Fbxl5 cKO, B6-Fbxl5 floxed
H-2 Haplotype No Data
ES cell line E14 [129P2/OlaHsd]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Keiichi Nakayama, Medical Institute of Bioregulation, Kyushu University. E14 ES cells were used. The mutant mice were crossed to C57BL/6J (N7 generations).
Strain description Fbx15 gene floxed mice (Flox type). Exons 4 and 5 were flanked by loxP sites.
Colony maintenance Heterozygote x Wild-type [or Crossing to C57BL/6JJcl]
Health Report
Gene Details
Promoter No Data
1 Symbol Fbxl5
Symbol name F-box and leucine-rich repeat protein 5
Chromosome 5
Common name No Data
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 5
Common name No Data
Symbol description No Data
References

Research applications Cre/loxP system,
Metabolism Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Nakayama, Keiichi (Medical institute of bioregulation, Kyushu University) Nakayama, Keiichi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC09759, B6.129P2-Chd8<tm2.1Kei>

RBRC No. RBRC09759
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129P2-Chd8<tm2.1Kei>
Former Common name Chd8L KO
H-2 Haplotype No Data
ES cell line E14 [129P2/OlaHsd]
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Deposited by Keiichi Nakayama, Medical Institute of Bioregulation, Kyusyu University in 2016. E14(129P2/OlaHsd) ES cell line was used. C57BL/6 congenic strain.
Strain description Chd8l (chromodomain helicase DNA binding protein 8 long isoform) knockout mice. Homozygous mutants are lethal. A pair of loxP sites with a neo gene cassette flanking exons 11 to 13, and then these exons were deleted by Cre expression in ES cells. Mouse strain carrying deletion of both long isoform (Chd8l) and short isoform (Chd8s) is available as RBRC09758.
Health Report
Gene Details
Promoter No Data
1 Symbol Chd8
Symbol name chromodomain helicase DNA binding protein 8
Chromosome 14
Common name No Data
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 14
Common name No Data
Symbol description No Data
References No Data

Research applications Cre/loxP system,
Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 Mouse of the Month Nov 2018
2 Genotyping protocol <PCR>
Depositor Nakayama, Keiichi (Medical institute of bioregulation, Kyushu University) Nakayama, Keiichi
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC06391, B6;129P2-Fbxo4<tm1Kei>

RBRC No. RBRC06391
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129P2-Fbxo4<tm1Kei>
Former Common name Fbxo4 KO, B6-Fbxo4 KO
H-2 Haplotype No Data
ES cell line E14 [129P2/OlaHsd]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Keiichi Nakayama, Medical Institute of Bioregulation, Kyushu University. E14 ES cells were used. The mutant mice were crossed to C57BL/6J.
Strain description Fbxo4 gene knockout mice. Exons 4 to 5 were raplaced with an IRES-lacZ/neo cassette.
Colony maintenance Homozygote x Homozygote [or Crossing to C57BL/6JJcl]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name SV40 polyA signal
Chromosome 15
Common name No Data
Symbol description No Data
2 Symbol Fbxo4
Symbol name F-box protein 4
Chromosome 15
Common name No Data
Symbol description No Data
3 Symbol IRES
Symbol name internal ribosomal entry site (EMCV)
Chromosome 15
Common name No Data
Symbol description No Data
4 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 15
Common name No Data
Symbol description No Data
5 Symbol loxP
Symbol name phage P1 loxP
Chromosome 15
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
6 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 15
Common name No Data
Symbol description No Data
References

Research applications Cre/loxP system,
Fluorescent Proteins/lacZ System
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 Lab HP
Depositor Nakayama, Keiichi (Medical institute of bioregulation, Kyushu University) Nakayama, Keiichi
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC10084, B6.Cg-Zfyve27<tm1Kei>

RBRC No. RBRC10084
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.Cg-Zfyve27<tm1Kei>
Former Common name Prt KO
H-2 Haplotype No Data
ES cell line E14 [129P2/OlaHsd]
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name SV40 PolyA
Chromosome 19
Common name No Data
Symbol description No Data
2 Symbol Zfyve27
Symbol name zinc finger, FYVE domain containing
Chromosome 19
Common name No Data
Symbol description No Data
3 Symbol loxP
Symbol name phage P1 loxP
Chromosome 19
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
4 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 19
Common name No Data
Symbol description No Data
References No Data

Research applications Cre/loxP system
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Nakayama, Keiichi (Medical institute of bioregulation, Kyushu University) Nakayama, Keiichi
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC06392, B6;129P2-Fbxo45<tm1Kei>

RBRC No. RBRC06392
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129P2-Fbxo45<tm1Kei>
Former Common name Fbxo45 KO, B6-Fbxo45 KO
H-2 Haplotype No Data
ES cell line E14 [129P2/OlaHsd]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Keiichi Nakayama, Medical Institute of Bioregulation, Kyushu University. E14 ES cells were used. The mutant mice were crossed to C57BL/6J over 7 times.
Strain description Fbxo41 gene knockout mice. Exon 1 was replaced with an IRES-lacZ/neo cassette.
Colony maintenance Heterozygote x Wild-type [C57BL/6JJcl]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name SV40 polyA signal
Chromosome 16
Common name No Data
Symbol description No Data
2 Symbol Fbxo45
Symbol name F-box protein 45
Chromosome 16
Common name No Data
Symbol description No Data
3 Symbol IRES
Symbol name internal ribosomal entry site (EMCV)
Chromosome 16
Common name No Data
Symbol description No Data
4 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 16
Common name No Data
Symbol description No Data
5 Symbol loxP
Symbol name phage P1 loxP
Chromosome 16
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
6 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 16
Common name No Data
Symbol description No Data
References

Research applications Cre/loxP system,
Developmental Biology Research,
Fluorescent Proteins/lacZ System,
Neurobiology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 Lab HP
Depositor Nakayama, Keiichi (Medical institute of bioregulation, Kyushu University) Nakayama, Keiichi
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC10321, 129.129P2-Aldh2<tm1Kaw>

RBRC No. RBRC10321
Type Targeted MutationCartagena
Species Mus musculus
Strain name 129.129P2-Aldh2<tm1Kaw>
Former Common name Aldh2 KO mice
H-2 Haplotype No Data
ES cell line E14 [129P2/OlaHsd]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name SV40 polyA
Chromosome 5
Common name No Data
Symbol description No Data
2 Symbol Aldh2
Symbol name aldehyde dehydrogenase 2, mitochondrial
Chromosome 5
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 5
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
Additional information
1 No Data
Depositor Nakayama, Keiichi (Medical institute of bioregulation, Kyushu University) Nakayama, Keiichi
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months