RBRC01730, C.129S2-Ptprc<tm1Tyb>/Rbrc

RBRC No. RBRC01730
Type Targeted MutationCartagena
Species Mus musculus
Strain name C.129S2-Ptprc<tm1Tyb>/Rbrc
Former Common name CD45 knockout mouse
H-2 Haplotype No Data
Donor strain 129S2/SvPas via D2 ES cell line
Background strain BALB/cAnNCrlCrlj
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Dr. Victor L J Tybulewicz at National Institute for Medical Research in 1999. A neo was transfered into D2 ES cells to reolace the exon 12 of the Ptprc gene. BALB/c background.
Strain description CD45 is a transmembrane tyrosine phosphatase implicated in the control of T cell receptor signaling. CD45 homozygous mutant mice in the BALB/c background were gorssly normal and fertile.
Colony maintenance Backcross to BALB/c (Heterozygote x BALB/cAnN)
Health Report
Gene Details
Promoter No Data
1 Symbol Ptprc
Symbol name protein tyrosine phosphatase, receptor type, C
Chromosome 1
Common name B220, CD45, Cd45, CD45R, Ly-5, Lyt-4, T200
Symbol description No Data
2 Symbol poly A
Symbol name HSV TK poly A
Chromosome 1
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 1
Common name neo; neomycin;
Symbol description No Data
References Eur J Immunol. 1999 Sep;29(9):2923-33.

Greatly reduced efficiency of both positive and negative selection of thymocytes in CD45 tyrosine phosphatase-deficient mice.
Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Eur. immunol., 29, 2923-2933 (1999).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Research Purpose only. The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEVELOPER (Dr. Victor Tybulewicz).
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Koyasu, Shigeo (Keio University) Koyasu, Shigeo
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC01974, 129S6.129X1(B6)-Dsg3<tm1>

RBRC No. RBRC01974
Type Targeted MutationCartagena
Species Mus musculus
Strain name 129S6.129X1(B6)-Dsg3<tm1>
Former Common name Desmoglein 3
H-2 Haplotype No Data
Background strain 129S6/SvEvTac
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Dsg3
Symbol name desmoglein 3
Chromosome 18
Common name No Data
Symbol description No Data
2 Symbol No Data
Symbol name herpes simplex virus thymidine kinase gene PolyA (HSV TK gene Poly A)
Chromosome 18
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 18
Common name neo; neomycin;
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Koyasu, Shigeo (Keio University) Koyasu, Shigeo
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC02298, C.Cg-Il3<tm1Glli>

RBRC No. RBRC02298
Type Targeted MutationCartagena
Species Mus musculus
Strain name C.Cg-Il3<tm1Glli>
Former Common name IL-3 knock-out mouse
H-2 Haplotype No Data
ES cell line D3 [129S2/SvPas]
Background strain BALB/cAnNTac
Appearance
1 Appearance albino
Genotype A/A b/b c/c
Strain development Developed by Dr. Glenn Dranoff, Dana-Farber Cancer Institute, Harvard Medical School in 1998. Mutant mice were backcrossed to C57BL/6 for 9 gnerations, and then to BALB/cAnNTac for 3 generations. Deposited by Dr. Shigeo Koyasu, Keio University School of Medicine.
Strain description Interluekin-3 is a growth factor of hematopoieic progenitors that yields multipotential blast cells, mast cells, basophils,neutrophils, macrophages, eosinophils, erythrocytes, megakaryocytes, and dendritic cells. IL-3 null mutant mice show unimpaired hematopoiesis, but contact hypersensitivity reactions are compromised.
Colony maintenance Backcross to BALB/c (Heterozygote x BALB/cAnNTac)
Health Report
Gene Details
Promoter No Data
1 Symbol Il3
Symbol name Interleukin 3
Chromosome 11
Common name BPA, Csfmu, HCGF, Il-3, MCGF, PSF
Symbol description No Data
2 Symbol poly A
Symbol name mouse PGK poly A
Chromosome 11
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 11
Common name neo; neomycin;
Symbol description No Data
References

Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEVELOPER (Glenn Dranoff, MD, Harvard Medical School, Dana-Farber Cancer Institute E-mail: glenn_dranoff@dfci.harvard.edu).
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Koyasu, Shigeo (Keio University) Koyasu, Shigeo
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade. Nat Commun.4: 2847 (2013).(24284909)
Leyva-Castillo JM, Hener P, Michea P, Karasuyama H, Chan S, Soumelis V, Li M.
Basophil-derived interleukin-4 controls the function of natural helper cells, a member of ILC2s, in lung inflammation. Immunity.40(5): 758-71 (2014).(24837103)
Motomura Y, Morita H, Moro K, Nakae S, Artis D, Endo TA, Kuroki Y, Ohara O, Koyasu S, Kubo M.
Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis. Science.347(6227): 1260-5. (2015).(25766237)
Weber GF, Chousterman BG, He S, Fenn AM, Nairz M, Anzai A, Brenner T, Uhle F, Iwamoto Y, Robbins CS, Noiret L, Maier SL, Zönchen T, Rahbari NN, Schöch S, Klotzsche-von Ameln A, Chavakis T, Weitz J, Hofer S, Weigand MA, Nahrendorf M, Weissleder R, Swirski FK.

RBRC02300, B6.129P2-Pten<tm2Mak>

RBRC No. RBRC02300
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6.129P2-Pten<tm2Mak>
Former Common name Pten-flox mouse (C57BL/6)
H-2 Haplotype No Data
ES cell line E14 [129P2/OlaHsd]
Background strain No Data
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Dr. Tak W. Mak, Ontario Cancer Institute in 2001. Deposited by Dr. Shigeo Koyasu, Keio University School of Medicine. C57BL/6N background.
Strain description Pten is a lipid phosphatase associated with tumor suppression. This conditional knockout mice have a loxP-flanked Pten allele. Conditional Pten deficient mice can be generated by crossing with tissue-specific Cre mice.
Colony maintenance backcross to C57BL/6 (Heterozygote x C57BL/6NTac)
Health Report
Gene Details
Promoter No Data
1 Symbol Pten
Symbol name phosphatase and tensin homolog
Chromosome 19
Common name 2310035O07Rik, A130070J02Rik, MMAC1, TEP1
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 19
Common name No Data
Symbol description No Data
References

Research applications Cancer Research,
Cell Biology Research,
Cre/loxP system,
General Purpose
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEVELOPER (Tak W. Mak, Division of Stem Cell and Developmental Biology, Advanced Medical Discovery Institute/Ontario Cancer Institute E-mail: tmak@uhnresearch.ca).
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Koyasu, Shigeo (Keio University) Koyasu, Shigeo
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Regulation of RhoA by STAT3 coordinates glial scar formation. J. Cell Biol.216(8): 2533-2550 (2017).(28642362)
Renault-Mihara F, Mukaino M, Shinozaki M, Kumamaru H, Kawase S, Baudoux M, Ishibashi T, Kawabata S, Nishiyama Y, Sugai K, Yasutake K, Okada S, Nakamura M, Okano H.
Generation of transgenic mouse line with prostate-specific expression of codon-improved Cre recombinase. Prostate Int. (2018).(30140659)
Mayuko Kanayama, Kazuki Nakao, Shigeo Horie, Atsu Aiba.

RBRC02301, C.Cg-Pten<tm2Mak>

RBRC No. RBRC02301
Type Targeted MutationCartagena
Species Mus musculus
Strain name C.Cg-Pten<tm2Mak>
Former Common name Pten-flox mouse (BALB/c)
H-2 Haplotype No Data
Background strain BALB/cAnNTac
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Pten
Symbol name phosphatase and tensin homolog
Chromosome 19
Common name 2310035O07Rik, A130070J02Rik, MMAC1, TEP1
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 19
Common name No Data
Symbol description No Data
References

Research applications Cancer Research,
Cell Biology Research,
Cre/loxP system,
General Purpose
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEVELOPER (Tak W. Mak, Division of Stem Cell and Developmental Biology, Advanced Medical Discovery Institute/Ontario Cancer Institute E-mail: tmak@uhnresearch.ca).
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Koyasu, Shigeo (Keio University) Koyasu, Shigeo
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC02302, B6.129P2-Lyzs<tm1(cre)Ifo>

RBRC No. RBRC02302
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6.129P2-Lyzs<tm1(cre)Ifo>
Former Common name LysM-Cre knock-in mice (C57BL/6)
H-2 Haplotype No Data
ES cell line E14 [129P2/OlaHsd]
Background strain C57BL/6NTac
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Technical University of Munich, Irmgard Foerster. Deposited by Shigeo Koyasu, School of Medicine, Keio University through Akita University Graduate School of Medicine. E14 ES cells were used to generate the knock-in mice. The mice were crossed to C57BL/6 for several times, and then backcrossed to C57BL/6NTac and BALB/cAnN, respectively (RBRC02302 and RBRC02303).
Strain description Lyzs (Lyz2, lysozyme 2) Cre knock-in mice, known as the LysMcre mouse. A NLS-cre cDNA was inserted into the endogenous ATG start site of Lyz2 gene. LysMcre mice allow for both specific and highly efficient Cre-mediated deletion of loxP-flanked target genes in myeloid cells. C57BL/6 background (RBRC02302) and BALB/c background (RBRC02303).
Colony maintenance Homozygote x Homozygote [or Crossing to C57BL/6NTac]
Health Report
Gene Details
Promoter No Data
1 Symbol Lyzs
Symbol name lysozyme
Chromosome 10
Common name LC, Lys-cre, LysM Cre, lysM/cre, LysMCre, LysMcre
Symbol description No Data
2 Symbol Frt
Symbol name yeast FRT (flippase recombination target) site
Chromosome 10
Common name No Data
Symbol description No Data
3 Symbol cre
Symbol name Phage P1 Cre recombinase
Chromosome 10
Common name No Data
Symbol description No Data
4 Symbol nls
Symbol name SV40 large T antigen nuclear localization signal (NLS)
Chromosome 10
Common name No Data
Symbol description No Data
References

Research applications Cell Biology Research,
Cre/loxP system,
FLP/frt system
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEVELOPER, Dr. Irmgard Foerster, Life and Medical Sciences (LIMES) Institute, University of Bonn E-mail: irmgard.foerster@uni-bonn.de.
Additional information
1 Lab HP
2 Genetic Background
3 Genotyping protocol <PCR>
Depositor Koyasu, Shigeo (Keio University) Koyasu, Shigeo
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

Live
Live mouse :
BRC mice in Publications
Title Journal
(PMID)
Author
IRF4 in Dendritic Cells Inhibits IL-12 Production and Controls Th1 Immune Responses against Leishmania major. J Immunol.192(5): 134288 (2014).(24489086)
Akbari M, Honma K, Kimura D, Miyakoda M, Kimura K, Matsuyama T, Yui K.
Prostaglandin Transporter OATP2A1/SLCO2A1 Is Essential for Body Temperature Regulation during Fever. J. Neurosci.38(24): 5584-5595 (2018).(29899035)
Nakamura Y, Nakanishi T, Shimada H, Shimizu J, Aotani R, Maruyama S, Higuchi K, Okura T, Deguchi Y, Tamai I.

RBRC00522, C57BL/6-Rag2 tm1Fwa -IL2rb tm1Mak

RBRC No. RBRC00522
Type Targeted Mutation CongenicCartagena 18wks,♂
Species Mus musculus
Strain name C57BL/6-Rag2tm1Fwa-IL2rbtm1Mak
Former Common name C57BL/6-Rag2tm1Fwa-IL2rbtm1Och
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance black
Genotype No Data
Strain development 1998 by Koyasu at Keio Univ. School of Med.
Original :
Rag2tm1Fwa :1992 by F. W. Alt at Columbia Univ., N.Y. USA
IL2rbtm1Och:1995 by T. W. Mak at Ontario Cancer Institute, Toronto, Canada
Strain description They lack T, B and NK cells. Furthermore, Macrophages and DCs have some functional defects.
Colony maintenance Nothing special. Breed well.
Health Report
Gene Details
Promoter No Data
1 Symbol Il2rb
Symbol name interleukin 2 receptor, beta chain
Chromosome 15
Common name CD122, IL-2 receptor beta chain, Il-2Rbeta, p70
Symbol description No Data
2 Symbol Rag2
Symbol name recombination activating gene 2
Chromosome 2
Common name Rag-2
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 15
Common name neo; neomycin;
Symbol description No Data
4 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 2
Common name neo; neomycin;
Symbol description No Data
References Cell. 1992 Mar 6;68(5):855-67.
Eur J Immunol. 2001 Nov;31(11):3147-52.
J Immunol. 1996 Nov 15;157(10):4379-89.
Nat Immunol. 2001 Dec;2(12):1138-43.
Science. 1995 Jun 9;268(5216):1472-6.

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement.
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement.
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement.
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement.
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement.
Research applications Cell Biology Research,
Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Koyasu, Shigeo (Keio University) Koyasu, Shigeo
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02303, C.Cg-Lyzs<tm1(cre)Ifo>

RBRC No. RBRC02303
Type Targeted MutationCartagena
Species Mus musculus
Strain name C.Cg-Lyzs<tm1(cre)Ifo>
Former Common name LysM-Cre knock-in mice (BALB/c)
H-2 Haplotype No Data
ES cell line E14 [129P2/OlaHsd]
Background strain C57BL/6NCrlCrlj
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Technical University of Munich, Irmgard Foester. Deposited by Shigeo Koyasu, School of Medicine, Keio University through Akita University Graduate School of Medicine. E14 ES cells were used to generate the knock-in mice. The mice were crossed to C57BL/6 for several times, and then backcrossed to C57BL/6NTac and BALB/cAnN, respectively (RBRC02302 and RBRC02303).
Strain description Lyzs (Lyz2, lysozyme 2) Cre knock-in mice, known as the LysMcre mouse. A NLS-cre cDNA was inserted into the endogenous ATG start site of Lyz2 gene. LysMcre mice allow for both specific and highly efficient Cre-mediated deletion of loxP-flanked target genes in myeloid cells. C57BL/6 background (RBRC02302) and BALB/c background (RBRC02303).
Colony maintenance Homozygote x Homozygote [or Crossing to BALB/cAnN]
Health Report
Gene Details
Promoter No Data
1 Symbol Lyzs
Symbol name lysozyme
Chromosome 10
Common name LC, Lys-cre, LysM Cre, lysM/cre, LysMCre, LysMcre
Symbol description No Data
2 Symbol Frt
Symbol name yeast FRT (flippase recombination target) site
Chromosome 10
Common name No Data
Symbol description No Data
3 Symbol cre
Symbol name Phage P1 Cre recombinase
Chromosome 10
Common name No Data
Symbol description No Data
4 Symbol nls
Symbol name SV40 large T antigen nuclear localization signal (NLS)
Chromosome 10
Common name No Data
Symbol description No Data
References

Research applications Cell Biology Research,
Cre/loxP system,
FLP/frt system
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEVELOPER. Dr. Irmgard Foerster, Life and Medical Sciences (LIMES) Institute, University of Bonn E-mail: irmgard.foerster@uni-bonn.de.
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Koyasu, Shigeo (Keio University) Koyasu, Shigeo
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00850, B6.129P2-Itgal tm1Mak

RBRC No. RBRC00850
Type Targeted Mutation CongenicCartagena
Species Mus musculus
Strain name B6.129P2-Itgaltm1Mak
Former Common name C57BL/6-[KO]LFA-1; B6.129P2-Itgb2tm1Oci
H-2 Haplotype No Data
Donor strain 129P2/OlaHsd via E14 ES cell line
Background strain No Data
Appearance
1 Appearance black
Genotype No Data
Strain development From Tak. W. Mak of ontario Cancer Institute, N6
Strain description Original line was established by Tak Mak at Ontario Cancer Institute in Tronto (Schmits et al., J. Exp. Med., 183, 1415, 1996). Neo registance gene construct was introduced into the CD11a allele of an ES cell line E14k of 129/Ola origin. Mutant ES cells were injected to C57BL/6 blastocysts. Chimeras were mated with C57BL/6 and was backcrossed to C57BL/6 for 6 generations. After embryo transfer at Taconic, the colony has been maintained through intercrossing of homozygous mice.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Itgal
Symbol name integrin alpha L
Chromosome 7
Common name CD11a, Integrin alpha L
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 7
Common name neo; neomycin;
Symbol description No Data
References J Exp Med. 1996 Apr 1;183(4):1415-26.

LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Koyasu, Shigeo (Keio University) Koyasu, Shigeo
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells. Nat Commun8(1): 1592 (2017).(29150602)
Saitoh SI, Abe F, Kanno A, Tanimura N, Mori Saitoh Y, Fukui R, Shibata T, Sato K, Ichinohe T, Hayashi M, Kubota K, Kozuka-Hata H, Oyama M, Kikko Y, Katada T, Kontani K, Miyake K.

RBRC02304, B6.Cg-Kit<W-sh>(N18)

RBRC No. RBRC02304
Type Spontaneous Mutation Congenic wks
Species Mus musculus
Strain name B6.Cg-Kit<W-sh>(N18)
Former Common name C57BL6-W N18
H-2 Haplotype No Data
Background strain C57BL/6NTac
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Kit
Symbol name kit oncogene
Chromosome 5
Common name belly-spot, c-KIT, CD117, Dominant white spotting, Steel Factor Receptor, Tr-kit
Symbol description No Data
References Am J Pathol. 2005 Sep;167(3):835-48.
Development. 1993 Jul;118(3):705-17.
Genet Res. 1982 Jun;39(3):315-22.

Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
Research applications Dermatology Research,
Developmental Biology Research,
Immunology and Inflammation Research,
Reproductive Biology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT agrees to use of BIOLOGICAL RESOURCE only for publishing the research papers. In publishing research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowlidgement to the DEPOSITOR is requested.
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Koyasu, Shigeo (Keio University) Koyasu, Shigeo
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months