RBRC10428, B6.Cg-Xkr8<tm1.1Osa>

RBRC No. RBRC10428
Type Targeted Mutation CongenicCartagena
Species Mus musculus
Strain name B6.Cg-Xkr8<tm1.1Osa>
Former Common name Xkr8 flox/flox
H-2 Haplotype No Data
ES cell line Bruce 4 [B6.Cg-Thy1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Frt
Symbol name yeast FRT (flippase recombination target) site
Chromosome 4
Common name No Data
Symbol description No Data
2 Symbol Xkr8
Symbol name X-linked Kx blood group related 8
Chromosome 4
Common name No Data
Symbol description No Data
3 Symbol loxP
Symbol name phage P1 loxP
Chromosome 4
Common name No Data
Symbol description No Data
References No Data

Research applications Cre/loxP system,
FLP/frt system
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Science, 341, 403-406 (2013).
The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Nagata, Shigekazu (Graduate School of Medicine, Kyoto University) Nagata, Shigekazu
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC10466, MRL.Cg-Xkr8<tm1.2Osa>

RBRC No. RBRC10466
Type Targeted MutationCartagena
Species Mus musculus
Strain name MRL.Cg-Xkr8<tm1.2Osa>
Former Common name Xkr8-/- MRL mice
H-2 Haplotype No Data
ES cell line Bruce 4 [B6.Cg-Thy1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Xkr8
Symbol name X-linked Kx blood group related 8
Chromosome 4
Common name No Data
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 4
Common name No Data
Symbol description No Data
References No Data

Research applications Cre/loxP system
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Proc. Natl. Acad. Sci. USA, 115; 2132-2137 (2018).
The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Nagata, Shigekazu (Graduate School of Medicine, Kyoto University) Nagata, Shigekazu
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

Live
Live mouse :

RBRC01474, B6.129-Fas<tm1Osa>/OsaRbrc

RBRC No. RBRC01474
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6.129-Fas<tm1Osa>/OsaRbrc
Former Common name B6 Fas-KO
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Drs. Masashi Adachi and Shigekazu Nagata at Osaka University Medical School in 1995.
Strain description Fas is a cell surface receptor belonging to the tumor necrosis factor receptor superfamily which transduces apoptotic signals in many cell types. Fas deficient mutant mice show lymphoma and autoimmune disorders. In a few month after birth, the mice develop lymphadenoma and splenomegaly by an accumulation of abnormal polyclonal T cells with the CD4-CD8- double negative.
Colony maintenance Backcross to C57BL/6 (Heterozygote x C57BL/6NCrlCrlj)
Homozygous mutant mice show lymphoma and autoimmune disorders. 50% dead at about 5 months of age.
Health Report
Gene Details
Promoter No Data
1 Symbol Fas
Symbol name Fas (TNF receptor superfamily member)
Chromosome 19
Common name APO-1, CD95, TNFR6, Tnfrsf6
Symbol description No Data
2 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 19
Common name No Data
Symbol description E. coli beta galactosidase
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 19
Common name neo; neomycin;
Symbol description No Data
References Nat Genet. 1995 Nov;11(3):294-300.

Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver.
Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Nature Genetics, 11, 294-300 (1995).
RECIPIENT may only use the BIOLOGICAL RESOURCE for non-commercial academic research purpose.
The RECIPIENT should negotiate with the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Nagata, Shigekazu (Graduate School of Medicine, Kyoto University) Nagata, Shigekazu
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC01475, B6;129-Fas<tm1Osa>/OsaRbrc

RBRC No. RBRC01475
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129-Fas<tm1Osa>/OsaRbrc
Former Common name Agouti Fas-KO
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Drs. Masashi Adachi and Shigekazu Nagata at Osaka University Medical School in 1995.
Strain description No Data
Colony maintenance Sibling Mating (Heterozygote x Wild-type, Heterozygote)
Health Report
Gene Details
Promoter No Data
1 Symbol Fas
Symbol name Fas (TNF receptor superfamily member)
Chromosome 19
Common name APO-1, CD95, TNFR6, Tnfrsf6
Symbol description No Data
2 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 19
Common name No Data
Symbol description E. coli beta galactosidase
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 19
Common name neo; neomycin;
Symbol description No Data
References Nat Genet. 1995 Nov;11(3):294-300.

Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver.
Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Nature Genetics, 11, 294-300 (1995).
RECIPIENT may only use the BIOLOGICAL RESOURCE for non-commercial academic research purpose.
The RECIPIENT should negotiate with the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Nagata, Shigekazu (Graduate School of Medicine, Kyoto University) Nagata, Shigekazu
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC01476, MRL.129P2(B6)-Fas<tm1Osa>/OsaRbrc

RBRC No. RBRC01476
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name MRL.129P2(B6)-Fas<tm1Osa>/OsaRbrc
Former Common name MRL Fas-KO
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Drs. Masashi Adachi and Shigekazu Nagata at Osaka University Medical School in 1995.
Strain description No Data
Colony maintenance Backcross to MRL/MpJJmsSlc (Heterozygote x C57BL/6NCrlCrlj)
Health Report
Gene Details
Promoter No Data
1 Symbol Fas
Symbol name Fas (TNF receptor superfamily member)
Chromosome 19
Common name APO-1, CD95, TNFR6, Tnfrsf6
Symbol description No Data
2 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 19
Common name No Data
Symbol description E. coli beta galactosidase
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 19
Common name neo; neomycin;
Symbol description No Data
References Nat Genet. 1995 Nov;11(3):294-300.

Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver.
Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Nature Genetics, 11, 294-300 (1995).
RECIPIENT may only use the BIOLOGICAL RESOURCE for non-commercial academic research purpose.
The RECIPIENT should negotiate with the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Nagata, Shigekazu (Graduate School of Medicine, Kyoto University) Nagata, Shigekazu
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC01723, B6;129-Dffb<tm1Osa>/OsaRbrc

RBRC No. RBRC01723
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6;129-Dffb<tm1Osa>/OsaRbrc
Former Common name CAD KO; CAD Knockout mouse
H-2 Haplotype No Data
Donor strain (129X1/SvJ x 129S1/Sv)F1-Kitl+ via R1 ES cell line
Background strain No Data
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Drs. Kohki Kawane and Shigekazu Nagata at Osaka University in 2003. A neomycin cassette replaced exons 1-6 and part of 7 of Dffb gene. The mutant mice were backcrossed to C57BL/6.
Strain description B6;129-Dffb<tm1Osa>. CAD, Caspase-activated DNase is an endonuclease that is activated in apoptotic cells. CAD deficient thymocytes did not undergo apoptotic DNA fragmentation, but their DNA was digested by thymic macrophages that effectively phagocytosed the
apoptotic thymocytes. This strain is useful for elucidation of the function of CAD gene.
Colony maintenance Backcross to C57BL/6 (Heterozygote x C57BL/6NCrlCrlj)
Homozygous mutant mice show no gross developmental abnormalities and are fertile with normal fecundity.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Dffb
Symbol name DNA fragmentation factor, beta subunit
Chromosome 4
Common name 40kDa, 5730477D02Rik, caspase-activated DNase, CPAN, DFF40, Didff
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 4
Common name neo; neomycin;
Symbol description No Data
References Nat Immunol. 2003 Feb;4(2):138-44. Epub 2003 Jan 13.

Impaired thymic development in mouse embryos deficient in apoptotic DNA degradation.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Nat. immunol., 4, 138-144 (2003).
RECIPIENT may only use the BIOLOGICAL RESOURCE for non-commercial academic research purpose.
The RECIPIENT should negotiate with the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Nagata, Shigekazu (Graduate School of Medicine, Kyoto University) Nagata, Shigekazu
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Novel role for caspase-activated DNase in the regulation of pathological cardiac hypertrophy. Hypertension65(4): 871-81 (2015).(25646292)
Gao L, Huang K, Jiang DS, Liu X, Huang D, Li H, Zhang XD, Huang K.

RBRC01724, B6;129-Dnase2b<tm1Osa>/OsaRbrc

RBRC No. RBRC01724
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129-Dnase2b<tm1Osa>/OsaRbrc
Former Common name DLAD KO
H-2 Haplotype No Data
Donor strain (129X1/SvJ x 129S1/Sv)F1-Kitl+ via R1 ES cell line
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Dnase2b
Symbol name deoxyribonuclease II beta
Chromosome 3
Common name Dlad, DnaseIIb
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 3
Common name neo; neomycin;
Symbol description No Data
References Nature. 2003 Aug 28;424(6952):1071-4.

Nuclear cataract caused by a lack of DNA degradation in the mouse eye lens.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Nature, 424, 1071-1074 (2003).
RECIPIENT may only use the BIOLOGICAL RESOURCE for non-commercial academic research purpose.
The RECIPIENT should negotiate with the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
For period of two (2) years after deposition by the DEPOSITOR to the REKEN BRC, the RECIPIENT agrees to include the DEPOSITOR/DEVELOPER as a co-author.
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Nagata, Shigekazu (Graduate School of Medicine, Kyoto University) Nagata, Shigekazu
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC01725, B6;129-Dnase2a<tm1Osa>/OsaRbrc

RBRC No. RBRC01725
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6;129-Dnase2a<tm1Osa>/OsaRbrc
Former Common name DNase II Hetero; DNase II Hetero Knockout mouse
H-2 Haplotype No Data
ES cell line R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]
Donor strain (129X1/SvJ x 129S1/Sv)F1-Kitl+ via R1 ES cell line
Background strain No Data
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Drs. Kohki Kawane and Shigekazu Nagata at Osaka University in 2001. A neomycin cassette replaced exons 1-5 and part of 6 of the Dnase2a gene. The mutant mice were backcrossed to C57BL/6.
Strain description B6;129-Dnase2a<tm1Osa>. In macrophage, DNase II, deoxyribonuclease II is responsible for digesting nuclear DNA expelled from erythroid precuursor cells. Homozygous null mice for DNase II are embryonic lethal due to sever anemia, and impaired definitive erythropoiesis in the fetal liver. This strain is useful for elucidation of the function of DNase II gene.
Colony maintenance Backcross to C57BL/6 (Heterozygote x C57BL/6NCrlCrlj)
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Dnase2a
Symbol name deoxyribonuclease II alpha
Chromosome 8
Common name No Data
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 8
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 8
Common name neo; neomycin;
Symbol description No Data
References

Research applications Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Science, 292, 1546-1549 (2001).
RECIPIENT may only use the BIOLOGICAL RESOURCE for non-commercial academic research purpose.
The RECIPIENT should negotiate with the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
For period of two (2) years after deposition by the DEPOSITOR to the REKEN BRC, the RECIPIENT agrees to include the DEPOSITOR/DEVELOPER as a co-author.
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Nagata, Shigekazu (Graduate School of Medicine, Kyoto University) Nagata, Shigekazu
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
STING manifests self DNA-dependent inflammatory disease. Proc Natl Acad Sci U S A. (2012).(23132945)
Ahn J, Gutman D, Saijo S, Barber GN.
DNase II-dependent DNA digestion is required for DNA sensing by TLR9. Nat Commun6: 5853 (2015).(25600358)
Chan MP, Onji M, Fukui R, Kawane K, Shibata T, Saitoh S, Ohto U, Shimizu T, Barber GN, Miyake K.

RBRC01726, B6;129-Mfge8<tm1Osa>/OsaRbrc

RBRC No. RBRC01726
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6;129-Mfge8<tm1Osa>/OsaRbrc
Former Common name MFG-E8 KO; MFG-E8 Knockout mouse
H-2 Haplotype No Data
ES cell line R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]
Donor strain (129X1/SvJ x 129S1/Sv)F1-Kitl+ via R1 ES cell line
Background strain C57BL/6
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Drs. Rikinari Hanayama and Shigekazu Nagata at Osaka University in 2004. A neomycin cassette replaced exons 4-6 of MFGE-8 gene. The mutant mice were backcrossed to C57BL/6N for at least 9 times.
Strain description B6;129-Mfge8<tm1Osa>. Apoptotic cells are rapidly uptaken by macrophages. This process is essential to prevent inflammation and the autoimmune response against intracellular antigens released from dying cells. Milk fat globule epidermal growth factor 8 (MFG-E8) is a protein that specifically binds to apoptotic cells and enhance the uptake of apoptotic cells by macrophages. The MFG-E8 deficient mice developed splenomegaly and suffered from glomerulonephritis as a result of autoantibody production. MFG-E8 is considered to have a critical role in removing apoptotic B cells in spleen and lymph nodes, and its deficiency can lead to autoimmune disease.
Colony maintenance Backcross to C57BL/6(Heterozygote x C57BL/6NCrlj)
Health Report
Gene Details
Promoter No Data
1 Symbol Mfge8
Symbol name milk fat globule-EGF factor 8 protein
Chromosome 7
Common name MFG-E8, Mfgm, SED1
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 7
Common name neo; neomycin;
Symbol description No Data
References Science. 2004 May 21;304(5674):1147-50.

Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice.
Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Science, 304, 1147-1150 (2004).
RECIPIENT may only use the BIOLOGICAL RESOURCE for non-commercial academic research purpose.
The RECIPIENT should negotiate with the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
For period of two (2) years after deposition by the DEPOSITOR to the REKEN BRC, the RECIPIENT agrees to include the DEPOSITOR/DEVELOPER as a co-author.
Additional information
1 Mouse of the Month Nov 2006
2 Lab HP
3 Genotyping protocol <PCR>
Depositor Nagata, Shigekazu (Graduate School of Medicine, Kyoto University) Nagata, Shigekazu
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

Live
Live mouse :

RBRC02442, MRL/MpJ-lpr-Tg(dLck-Fas)

RBRC No. RBRC02442
Type Targeted Mutation and TransgeneCartagena wks
Species Mus musculus
Strain name MRL/MpJ-lpr-Tg(dLck-Fas)
Former Common name T&B Tg lpr, Mm-MRL/MpJ-lpr/lpr-TgN(dLck-Fas)
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter mouse lck distal promoter
1 Symbol Fas
Symbol name Fas (TNF receptor superfamily member)
Chromosome UN
Common name APO-1, CD95, TNFR6, Tnfrsf6
Symbol description No Data
References

Research applications Apoptosis Research,
Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Eur. J. Immunol., 32, 223-230 (2002).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE. The RECIPIENT may only use the BIOLOGICAL RESOURCE for non-commercial academic research purpose.
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Nagata, Shigekazu (Graduate School of Medicine, Kyoto University) Nagata, Shigekazu
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months