RBRC00918, GATA-1 promoter-LacZ mice ITintIEintLacZ 226 line

RBRC No. RBRC00918
Type TransgeneCartagena
Species Mus musculus
Strain name GATA-1 promoter-LacZ mice ITintIEintLacZ 226 line
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter mouse GATA-1 promoter
1 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome UN
Common name No Data
Symbol description E. coli beta galactosidase
References Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4487-92.

GATA-1 transcription is controlled by distinct regulatory mechanisms during primitive and definitive erythropoiesis.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Proc. Natl. Acad. Sci. U.S.A. 94, 4487-4492 (1997).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The depositor should be a co-author in articles when the users publish their data using these mice for 2 year after provided. Users should contact the depositor in the case of application for any patents with the results from these mice.
Additional information
1 Lab HP (Japanese)
Depositor Yamamoto, Masayuki (University of tsukuba) Yamamoto, Masayuki
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00935, GATA-1 promoter-LacZ mice ITintdUE IEintLacZ 865 line

RBRC No. RBRC00935
Type TransgeneCartagena
Species Mus musculus
Strain name GATA-1 promoter-LacZ mice ITintdUE IEintLacZ 865 line
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter mouse GATA-1 promoter
1 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome UN
Common name No Data
Symbol description E. coli beta galactosidase
References Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4487-92.

GATA-1 transcription is controlled by distinct regulatory mechanisms during primitive and definitive erythropoiesis.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The depositor should be a co-author in articles when the users publish their data using these mice for 2 year after provided. Users should contact the depositor in the case of application for any patents with the results from these mice.
Additional information
1 Lab HP (Japanese)
Depositor Yamamoto, Masayuki (University of tsukuba) Yamamoto, Masayuki
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC01236, STOCK Ahr<tm1Yfk> Nfe2l2<tm1Mym>

RBRC No. RBRC01236
Type Targeted MutationCartagena
Species Mus musculus
Strain name STOCK Ahr<tm1Yfk> Nfe2l2<tm1Mym>
Former Common name Nrf2(+/-)::AhR(+/-) compound mouse
H-2 Haplotype No Data
Donor strain B6;129S6-Ahrtm1Yfk and STOCK-Nfe2l2tm1Yin
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Ahr
Symbol name aryl-hydrocarbon receptor
Chromosome 12
Common name Ah, Ahh, Ahre, dioxin receptor, In
Symbol description No Data
2 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 12
Common name No Data
Symbol description E. coli beta galactosidase
3 Symbol nls
Symbol name SV40 large T antigen nuclear localization signal (NLS)
Chromosome 12
Common name No Data
Symbol description No Data
4 Symbol Nfe2l2
Symbol name nuclear factor, erythroid derived 2, like 2
Chromosome 2
Common name Nrf2
Symbol description No Data
5 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 2
Common name No Data
Symbol description E. coli beta galactosidase
6 Symbol nls
Symbol name SV40 large T antigen nuclear localization signal (NLS)
Chromosome 2
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
7 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 12
Common name neo; neomycin;
Symbol description No Data
8 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 2
Common name neo; neomycin;
Symbol description No Data
References Biochem Biophys Res Commun. 1997 Jul 18;236(2):313-22.
Biochem Biophys Res Commun. 2003 Mar 28;303(1):105-11.
Genes Cells. 1997 Oct;2(10):645-54.

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements.
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements.
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements.
Research applications Cell Biology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Noda S.et al. (2003) BIochem Biophys Res Commun. 303:105-111.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT agrees to include the DEPOSITOR/DEVELOPER as a co-author in any publications resulted by the use of the BIOLOGICAL RESOURCE during the first 2 years after deposition by the DEPOSITOR to the RIKEN BRC. The RECIPIENT should contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 Lab HP (Japanese)
Depositor Yamamoto, Masayuki (University of tsukuba) Yamamoto, Masayuki
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC09487, C57BL/6N-Tyr<c-Brd>-Tg(IL6-Luc)

RBRC No. RBRC09487
Type TransgeneCartagena
Species Mus musculus
Strain name C57BL/6N-Tyr<c-Brd>-Tg(IL6-Luc)
Former Common name hIL6-BAC-Luc
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Tyr
Symbol name tyrosinase
Chromosome 7
Common name No Data
Symbol description No Data
2 Symbol Frt
Symbol name yeast FRT (flippase recombination target) site
Chromosome 7
Common name No Data
Symbol description No Data
3 Symbol No Data
Symbol name SV40 polyA
Chromosome UN
Common name No Data
Symbol description No Data
4 Symbol loxP
Symbol name phage P1 loxP
Chromosome UN
Common name No Data
Symbol description No Data
Promoter human IL6 promoter
5 Symbol luc
Symbol name luciferase
Chromosome UN
Common name No Data
Symbol description No Data
References No Data

Research applications Cre/loxP system,
FLP/frt system
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Mol Cell Biol. 2015 Aug 17. pii: MCB.00506-15.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, involving the DEPOSITOR in author byline is requested (by Aug 2017).
Additional information
1 Mouse of the Month May 2016
2 Genotyping protocol <PCR>
Depositor Yamamoto, Masayuki (Tohoku university) Yamamoto, Masayuki
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC00919, GATA-1 promoter-LacZ mice IE3.9intLacZ 455 line

RBRC No. RBRC00919
Type TransgeneCartagena
Species Mus musculus
Strain name GATA-1 promoter-LacZ mice IE3.9intLacZ 455 line
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter mouse GATA-1 promoter
1 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome UN
Common name No Data
Symbol description E. coli beta galactosidase
References Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4487-92.

GATA-1 transcription is controlled by distinct regulatory mechanisms during primitive and definitive erythropoiesis.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Proc. Natl. Acad. Sci. U.S.A. 94, 4487-4492 (1997).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The depositor should be a co-author in articles when the users publish their data using these mice for 2 year after provided. Users should contact the depositor in the case of application for any patents with the results from these mice.
Additional information
1 Lab HP (Japanese)
Depositor Yamamoto, Masayuki (University of tsukuba) Yamamoto, Masayuki
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00936, GATA-1 promoter-LacZ mice IT(dApaUE)IEintLacZ 254 line

RBRC No. RBRC00936
Type TransgeneCartagena
Species Mus musculus
Strain name GATA-1 promoter-LacZ mice IT(dApaUE)IEintLacZ 254 line
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter mouse GATA-1 promoter
1 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome UN
Common name No Data
Symbol description E. coli beta galactosidase
References Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4487-92.

GATA-1 transcription is controlled by distinct regulatory mechanisms during primitive and definitive erythropoiesis.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The depositor should be a co-author in articles when the users publish their data using these mice for 2 year after provided. Users should contact the depositor in the case of application for any patents with the results from these mice.
Additional information
1 Lab HP (Japanese)
Depositor Yamamoto, Masayuki (University of tsukuba) Yamamoto, Masayuki
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC01388, B6;129P2-Keap1<tm1Mym>/MymRbrc

RBRC No. RBRC01388
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129P2-Keap1<tm1Mym>/MymRbrc
Former Common name Keap1 knockout mice
H-2 Haplotype No Data
ES cell line E14 [129P2/OlaHsd]
Donor strain 129P2/OlaHsd via E14 ES cell line
Background strain No Data
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Masayuki Yamamoto, Center for Tsukuba Advanced Research Alliance, University of Tsukuba in 2003. Sequence encoding 8 through 204 of Keap1 was replaced with neomycin and nls-lacZ cassette.
Strain description Keap1 gene is a cytoplasmic protein, acts as a negative regulator of Nrf2 and as a sensor of xenobiotic and oxidative stresses. Double knockout mice of Nrf2 and Keap1 demonstrated that Nrf2 is a primary target of Keap1. Nrf2-Keap1 system is one of the major cellular protection mechanisms against xenobiotic and oxidative stresses. Keap1 homozygous mutant mice exhibit scaly skin, hyperkeratosis in the esophague and forestomatch, and died postnatally.
Colony maintenance Heterozygote x Wild-type [C57BL/6JJcl]. Homozygous mutant mice are postnatal letha.
Health Report
Gene Details
Promoter No Data
1 Symbol Keap1
Symbol name kelch-like ECH-associated protein 1
Chromosome 9
Common name No Data
Symbol description No Data
2 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 9
Common name No Data
Symbol description E. coli beta galactosidase
3 Symbol nls
Symbol name SV40 large T antigen nuclear localization signal (NLS)
Chromosome 9
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
4 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 9
Common name neo; neomycin;
Symbol description No Data
References Nat Genet. 2003 Nov;35(3):238-45. Epub 2003 Sep 28.

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation.
Research applications Fluorescent Proteins/lacZ System
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Nature Genetics, 35, 238-245 (2003).
The DEPOSITOR should be a co-author in the articles when the users publish their data using these mice for 2 year after deposition to the RIKEN BRC. Users should contact the DEPOSITOR in the case of application for any patents with the results from these mice.
Additional information
1 Lab HP (Japanese)
2 Mouse of the Month Oct 2005
3 Genotyping protocol <PCR>
Depositor Yamamoto, Masayuki (University of tsukuba) Yamamoto, Masayuki
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Transcript profiling identifies dynamic gene expression patterns and an important role for nrf2/keap1 pathway in the developing mouse esophagus. PLoS One.7(5): e36504 (2012).(22567161)
Chen H, Li J, Li H, Hu Y, Tevebaugh W, Yamamoto M, Que J, Chen X.
Effects of deficiency of Kelch-like ECH-associated protein 1 on skeletal organization: a mechanism for diminished nuclear factor of activated T cells cytoplasmic 1 during osteoclastogenesis. FASEB J.31(9): 4011-4022 (2017).(28515152)
Sakai E, Morita M, Ohuchi M, Kido MA, Fukuma Y, Nishishita K, Okamoto K, Itoh K, Yamamoto M, Tsukuba T.

RBRC09508, C57BL/6J-Tg(RP11-94J18/RP11-662G11)BMy

RBRC No. RBRC09508
Type TransgeneCartagena
Species Mus musculus
Strain name C57BL/6J-Tg(RP11-94J18/RP11-662G11)BMy
Former Common name 3q21q26 mouse line B
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Frt
Symbol name yeast FRT (flippase recombination target) site
Chromosome UN
Common name No Data
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome UN
Common name No Data
Symbol description No Data
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome UN
Common name No Data
Symbol description No Data
Promoter human GATA2 enhancer
4 Symbol MECOM
Symbol name MDS1 and EVI1 complex locus
Chromosome UN
Common name No Data
Symbol description No Data
References No Data

Research applications Cre/loxP system,
Hematological Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Cancer Cell 25, 415-427 (2014).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE,involving the DEPOSITOR in author byline is requested (by Oct 2017).
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Yamamoto, Masayuki (Tohoku university) Yamamoto, Masayuki
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC00920, GATA-1 promoter-LacZ mice IE3.9intLacZ 508 line

RBRC No. RBRC00920
Type TransgeneCartagena
Species Mus musculus
Strain name GATA-1 promoter-LacZ mice IE3.9intLacZ 508 line
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter mouse GATA-1 promoter
1 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome UN
Common name No Data
Symbol description E. coli beta galactosidase
References Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4487-92.

GATA-1 transcription is controlled by distinct regulatory mechanisms during primitive and definitive erythropoiesis.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Proc. Natl. Acad. Sci. U.S.A. 94, 4487-4492 (1997).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The depositor should be a co-author in articles when the users publish their data using these mice for 2 year after provided. Users should contact the depositor in the case of application for any patents with the results from these mice.
Additional information
1 Lab HP (Japanese)
Depositor Yamamoto, Masayuki (University of tsukuba) Yamamoto, Masayuki
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC00937, GATA-1 promoter-LacZ mice IT(dApaUE)IEintLacZ 260 line

RBRC No. RBRC00937
Type TransgeneCartagena
Species Mus musculus
Strain name GATA-1 promoter-LacZ mice IT(dApaUE)IEintLacZ 260 line
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter mouse GATA-1 promoter
1 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome UN
Common name No Data
Symbol description E. coli beta galactosidase
References Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4487-92.

GATA-1 transcription is controlled by distinct regulatory mechanisms during primitive and definitive erythropoiesis.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The depositor should be a co-author in articles when the users publish their data using these mice for 2 year after provided. Users should contact the depositor in the case of application for any patents with the results from these mice.
Additional information
1 Lab HP (Japanese)
Depositor Yamamoto, Masayuki (University of tsukuba) Yamamoto, Masayuki
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months