RBRC02327, NOD.129P2(B6)-Fcer1g<tm1Rav>

RBRC No. RBRC02327
Type Targeted Mutation CongenicCartagena wks
Species Mus musculus
Strain name NOD.129P2(B6)-Fcer1g<tm1Rav>
Former Common name NOD.γ-/-
H-2 Haplotype No Data
Background strain NOD/ShiJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Fcer1g
Symbol name Fc receptor, IgE, high affinity I, gamma polypeptide
Chromosome 1
Common name Fce1g, FcR-gamma, FcR[g], FcRgamma, Ly-50
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 1
Common name neo; neomycin;
Symbol description No Data
References J Immunol. 2007 Jul 15;179(2):764-74.

Activating Fc{gamma} Receptors Participate in the Development of Autoimmune Diabetes in NOD Mice.
Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Immunol., 179, 764-774 (2007).
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Takai, Toshiyuki (Tohoku University) Takai, Toshiyuki
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02328, NOD.129X1(B6)-Fcgr3<tm1Ttk>

RBRC No. RBRC02328
Type Targeted Mutation CongenicCartagena wks
Species Mus musculus
Strain name NOD.129X1(B6)-Fcgr3<tm1Ttk>
Former Common name NODIII-/-
H-2 Haplotype No Data
Background strain NOD/ShiJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Fcgr3
Symbol name receptor, IgG, low affinity III
Chromosome 1
Common name CD16, Fcg receptor III, FcgammaRIII
Symbol description No Data
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 1
Common name neo; neomycin;
Symbol description No Data
References J Immunol. 2007 Jul 15;179(2):764-74.

Activating Fc{gamma} Receptors Participate in the Development of Autoimmune Diabetes in NOD Mice.
Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Immunol., 179, 764-774 (2007).
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Takai, Toshiyuki (Tohoku University) Takai, Toshiyuki
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02329, NOD.129S4(B6)-Fcgr2b<tm1Ttk>

RBRC No. RBRC02329
Type Targeted Mutation CongenicCartagena
Species Mus musculus
Strain name NOD.129S4(B6)-Fcgr2b<tm1Ttk>
Former Common name NODIIB-/-
H-2 Haplotype No Data
Background strain NOD/ShiJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 1
Common name neo; neomycin;
Symbol description No Data
2 Symbol Fcgr2b
Symbol name Fc receptor, IgG, low affinity IIb
Chromosome 1
Common name targeted mutation 1, Toshiyuki Takai
Symbol description No Data
References J Immunol. 2007 Jul 15;179(2):764-74.

Activating Fc{gamma} Receptors Participate in the Development of Autoimmune Diabetes in NOD Mice.
Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Immunol., 179, 764-774 (2007).
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Takai, Toshiyuki (Tohoku University) Takai, Toshiyuki
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02330, NOD.Cg-Fcer1g<tm1Rav> Fcgr2b<tm1Ttk>

RBRC No. RBRC02330
Type Targeted Mutation CongenicCartagena
Species Mus musculus
Strain name NOD.Cg-Fcer1g<tm1Rav> Fcgr2b<tm1Ttk>
Former Common name NODFcγRnull
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance albino
Genotype A/A c/c
Strain development Developed by Drs. Y. Inoue and T. Takai, Tohoku University in 2004.
Strain description FcR common gamma-chain (Fc-Rgamma) deficient mice. NOD background.
Colony maintenance Sibling Mating (Homozygote x Homozygote)
This strain shows less severe insulitis, whereas after the onset of diabetes, homozygous and wild-type mice shows cimparable nsulitis indices.
Health Report
Gene Details
Promoter No Data
1 Symbol Fcer1g
Symbol name Fc receptor, IgE, high affinity I, gamma polypeptide
Chromosome 1
Common name Fce1g, FcR-gamma, FcR[g], FcRgamma, Ly-50
Symbol description No Data
2 Symbol Fcgr2b
Symbol name Fc receptor, IgG, low affinity IIb
Chromosome 1
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 1
Common name neo; neomycin;
Symbol description No Data
4 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 1
Common name neo; neomycin;
Symbol description No Data
References J Immunol. 2007 Jul 15;179(2):764-74.

Activating Fc{gamma} Receptors Participate in the Development of Autoimmune Diabetes in NOD Mice.
Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Immunol., 179, 764-774 (2007).
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Takai, Toshiyuki (Tohoku University) Takai, Toshiyuki
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Agonistic Anti-CD40 Induces Thyrocyte Proliferation and Promotes Thyroid Autoimmunity by Increasing CD40 Expression on Thyroid Epithelial Cells. J Immunol. (2013).(23509363)
Kayes T, Fang Y, Yu S, Downey E, Wang S, Braley-Mullen H.

RBRC02692, B6.129X1-Lilrb4a<tm1Ttk>

RBRC No. RBRC02692
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6.129X1-Lilrb4a<tm1Ttk>
Former Common name gp49B
H-2 Haplotype No Data
ES cell line RW4 [129X1/SvJ]
Background strain C57BL/6NCrlCrlj
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Dr. Toshiyuki Takai, Tohoku University in 2008.
Strain description Lilrb4 knock-out mice. Lilrb4 (gp49B) is a member of the immunoglobulin superfamily, containing immunoreceptor tyrosine-based inhibitory motifs that can deliver an inhibitor signal in mast and NK cells.
Colony maintenance Sibling x Sibling (Homozygote x Homozygote)
Homozygous mice are viable and fertile.
Health Report
BRC facility Health Report in the last year and a half

Examination Date Room Rack
Jul 10, 2017 2-検 G
May 15, 2017 2-検 G
Mar 13, 2017 2-検 G
Jan 16, 2017 2-検 G
Nov 14, 2016 2-検 G
Sep 12, 2016 2-検 G
Jul 11, 2016 2-検 G
May 16, 2016 2-検 G

Gene Details
Promoter No Data
1 Symbol Lilrb4a
Symbol name leukocyte immunoglobulin-like receport, subfamily B, member 4
Chromosome 10
Common name CD85K, Gp49b, HM18, ILT3, Lilrb4
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 10
Common name neo; neomycin;
Symbol description No Data
References

Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Biol. Chem., 273, 1070-1074 (1998). J. Immunol., 165, 4970-4977 (2000).
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Takai, Toshiyuki (Tohoku University) Takai, Toshiyuki
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Decidual Macrophage Functional Polarization during Abnormal Pregnancy due to Toxoplasma gondii: Role for LILRB4. Front Immunol8: 1013 (2017).(28883820)
Li Z, Zhao M, Li T, Zheng J, Liu X, Jiang Y, Zhang H, Hu X.