RBRC02258, B6;129S(Cg)-Grin2c<tm1Nak>

RBRC No. RBRC02258
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6;129S(Cg)-Grin2c<tm1Nak>
Former Common name NR2C KO
H-2 Haplotype No Data
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Motoya Katsuki, National Institutes of Natural Sciences (Institute of Medical Science, University of Tokyo).
Strain description NR2C (Grin2c) gene knockout mice. Homozygous mutant mice are viable and fertile.
Colony maintenance Homozygote x Homozygote [or Crossing to C57BL/6JJcl]
Health Report
Gene Details
Promoter No Data
1 Symbol Grin2c
Symbol name glutamate receptor, ionotropic, NMDA2C (epsilon 3)
Chromosome 11
Common name GluRepsilon3, NMDAR2C, NR2C
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 11
Common name neo; neomycin;
Symbol description No Data
References J Neurosci. 1996 Dec 15;16(24):7859-67.

Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Neurosci., 16, 7859-7867 (1996).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 Genetic Background
2 Genotyping protocol <PCR>
Depositor Sasaoka, Toshikuni (Niigata university) Sasaoka, Toshikuni
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02430, B6.Cg-Tg(HRAS/pBS302)1Mok

RBRC No. RBRC02430
Type Transgene CongenicCartagena
Species Mus musculus
Strain name B6.Cg-Tg(HRAS/pBS302)1Mok
Former Common name A-ras Tg, B6-Aras Tg
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Motoya Katsuki, National Institutes of Natural Sciences.
Strain description Human mutant HRAS gene transgenic mice.
Colony maintenance Carrier x Noncarrier [C57BL/6JJcl]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name No Data
Chromosome No Data
Common name No Data
Symbol description No Data
References not yet determined

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
未定
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Sasaoka, Toshikuni (Niigata university) Sasaoka, Toshikuni
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02457, B6;129S-Drd2<tm1Mok> Drd3<tm1Mok>

RBRC No. RBRC02457
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129S-Drd2<tm1Mok> Drd3<tm1Mok>
Former Common name D2RD3R-KO
H-2 Haplotype No Data
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Motoya Katsuki, National Institutes of Natural Sciences.
Strain description D2R (Drd2) and D3R (Drd3) genes double knockout mice. Mixed background.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Drd3
Symbol name dopamine receptor 3
Chromosome 16
Common name D3 receptor, D3R
Symbol description No Data
2 Symbol Drd2
Symbol name dopamine receptor D2
Chromosome 9
Common name D2 receptor, D2R, Drd-2
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 16
Common name neo; neomycin;
Symbol description No Data
4 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 9
Common name neo; neomycin;
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
5 Symbol Ecogpt
Symbol name E.coli xanthine phosphoribosyltransferase
Chromosome 16
Common name No Data
Symbol description No Data
References Genes Cells. 1996 Feb;1(2):253-68.

Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Genes Cells, 1, 253-268 (1996).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Sasaoka, Toshikuni (Niigata university) Sasaoka, Toshikuni
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02476, B6.Cg-Kras<tm1Mok> Il6st<tm1>

RBRC No. RBRC02476
Type Targeted Mutation CongenicCartagena
Species Mus musculus
Strain name B6.Cg-Kras<tm1Mok> Il6st<tm1>
Former Common name B6-Kras/gp130 KO
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Motoya Katsuki, National Institutes of Natural Sciences.
Strain description Kras and gp130 (Il6st) genes double knockout mice.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Il6st
Symbol name interleukin 6 signal transducer
Chromosome 13
Common name No Data
Symbol description No Data
2 Symbol Kras
Symbol name v-Ki-ras2 Kirsten rat sarcome viral oncogene homolog
Chromosome 6
Common name No Data
Symbol description No Data
References Oncogene. 1997 Sep 4;15(10):1151-9.

K-ras is essential for the development of the mouse embryo.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Oncogene, 15, 1151-1159 (1997).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Sasaoka, Toshikuni (Niigata university) Sasaoka, Toshikuni
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02525, B6.Cg-Tg(HRAS)2Mok Kit<Wv>

RBRC No. RBRC02525
Type Transgene CongenicCartagena
Species Mus musculus
Strain name B6.Cg-Tg(HRAS)2Mok Kit<Wv>
Former Common name HRAS Tg Wv mutant, B6-HRAS Tg#2/Wv
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Motoya Katsuki, National Institutes of Natural Sciences.
Strain description human HRAS transgene and Kit<Wv> double mutant mice.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Kit
Symbol name kit oncogene
Chromosome 5
Common name No Data
Symbol description No Data
2 Symbol HRAS
Symbol name Harvey rat sarcoma virus oncogene (human)
Chromosome UN
Common name No Data
Symbol description No Data
References Oncogene. 1990 Aug;5(8):1195-200.

Most tumors in transgenic mice with human c-Ha-ras gene contained somatically activated transgenes.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Oncogene, 5, 1195-1200 (1990).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Sasaoka, Toshikuni (Niigata university) Sasaoka, Toshikuni
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02259, B6.129S-Kras<tm1Mok>

RBRC No. RBRC02259
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6.129S-Kras<tm1Mok>
Former Common name K-ras KO, B6-Kras KO
H-2 Haplotype No Data
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Motoya Katsuki, National Institutes of Natural Sciences (Institute of Medical Science, University of Tokyo).
Strain description Kras gene knockout mice. Homozygous mutant mice are embryonic lethal.
Colony maintenance Heterozygote x Wild-type [C57BL/6JJcl]
Health Report
Gene Details
Promoter No Data
1 Symbol Kras
Symbol name v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Chromosome 6
Common name K-ras, Ki-ras, Kras-2, Kras2
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 6
Common name neo; neomycin;
Symbol description No Data
References Oncogene. 1997 Sep 4;15(10):1151-9.

K-ras is essential for the development of the mouse embryo.
Research applications Cancer Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Oncogene, 15, 1151-1159 (1997).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Sasaoka, Toshikuni (Niigata university) Sasaoka, Toshikuni
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC02431, B6.129-Drd2<tm1Mok> Drd3<tm1Mok> Drd4<tm1Mok>

RBRC No. RBRC02431
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129-Drd2<tm1Mok> Drd3<tm1Mok> Drd4<tm1Mok>
Former Common name D2R D3R D4R multiple KO, B6-D2R/D3R/D4R KO
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Motoya Katsuki, National Institutes of Natural Sciences.
Strain description D2R (Drd2), D3R (Drd3) and D4R (Drd4) triple knockout mice.
Health Report
Gene Details
Promoter No Data
1 Symbol Drd3
Symbol name dopamine receptor 3
Chromosome 16
Common name D3 receptor, D3R
Symbol description No Data
2 Symbol Drd4
Symbol name dopamine receptor 4
Chromosome 7
Common name D4R, Drd-4
Symbol description No Data
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 7
Common name No Data
Symbol description No Data
4 Symbol Drd2
Symbol name dopamine receptor D2
Chromosome 9
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
5 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 16
Common name No Data
Symbol description No Data
6 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 9
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
7 Symbol Ecogpt
Symbol name E.coli xanthine phosphoribosyltransferase
Chromosome 16
Common name No Data
Symbol description No Data
8 Symbol Ecogpt
Symbol name E.coli xanthine phosphoribosyltransferase
Chromosome 7
Common name No Data
Symbol description No Data
References Genes Cells. 1996 Feb;1(2):253-68.

Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Genes Cells, 1, 253-268 (1996).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Sasaoka, Toshikuni (Niigata university) Sasaoka, Toshikuni
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

Live
Live mouse :

RBRC02458, B6.129-Adcyap1<tm1Mok>

RBRC No. RBRC02458
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129-Adcyap1<tm1Mok>
Former Common name PACAP-KO
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Motoya Katsuki, National Institutes of Natural Sciences.
Strain description PACAP (Adcyap1) gene knockout mice.
Colony maintenance Heterozygote x Wild-type [C57BL/6JJcl]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Adcyap1
Symbol name adenylate cyclase activating polypeptide 1
Chromosome 17
Common name No Data
Symbol description No Data
References not yet determined

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
未定
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Sasaoka, Toshikuni (Niigata university) Sasaoka, Toshikuni
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02477, B6;129-Grin2a<tm1Nak> Grin2b<tm1Stl> Drd2<tm1Mok> Drd3<tm1Mok> Drd4<tm1Mok>

RBRC No. RBRC02477
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129-Grin2a<tm1Nak> Grin2b<tm1Stl> Drd2<tm1Mok> Drd3<tm1Mok> Drd4<tm1Mok>
Former Common name B6-NR2A/NR2B/D2R/D3R/D4R KO
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Motoya Katsuki, National Institutes of Natural Sciences.
Strain description NR2A (Grin2a), NR2B (Grin2b), D2R (Drd2), D3R (Drd3) and D4R (Drd4) genes multiple knockout mice.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Drd3
Symbol name dopamine receptor 3
Chromosome 16
Common name D3 receptor, D3R
Symbol description No Data
2 Symbol Grin2a
Symbol name glutamate receptor, ionotropic, NMDA2A (epsilon 1)
Chromosome 16
Common name No Data
Symbol description No Data
3 Symbol Grin2b
Symbol name glutamate receptor, ionotropic, NMDA2B (epsilon 2)
Chromosome 6
Common name GluRepsilon2, NMDAR2B, Nmdar2b, NR2B
Symbol description No Data
4 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 6
Common name neo; neomycin;
Symbol description No Data
5 Symbol Drd4
Symbol name dopamine receptor 4
Chromosome 7
Common name D4R, Drd-4
Symbol description No Data
6 Symbol Ecogpt
Symbol name E.coli xanthine phosphoribosyltransferase
Chromosome 7
Common name No Data
Symbol description No Data
7 Symbol Drd2
Symbol name dopamine receptor D2
Chromosome 9
Common name D2 receptor, D2R, Drd-2
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
8 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 16
Common name neo; neomycin;
Symbol description No Data
9 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 9
Common name neo; neomycin;
Symbol description No Data
Promoter mouse RNA polymerase II large subunit promoter
10 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 7
Common name neo; neomycin;
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
11 Symbol Ecogpt
Symbol name E.coli xanthine phosphoribosyltransferase
Chromosome 16
Common name No Data
Symbol description No Data
References Genes Cells. 1996 Feb;1(2):253-68.
J Neurosci. 1996 Dec 15;16(24):7859-67.

Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary.
Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Nerurosci., 16, 7859-7867 (1996).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Drs. Motoya Katsuki and Toshikuni Sasaoka is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Sasaoka, Toshikuni (Niigata university) Sasaoka, Toshikuni
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02526, C57BL/6-Kit<Wv>

RBRC No. RBRC02526
Type Spontaneous Mutation
Species Mus musculus
Strain name C57BL/6-Kit<Wv>
Former Common name B6-Wv
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Motoya Katsuki, National Institutes of Natural Sciences.
Strain description Kit<Wv> mutant mice.
Colony maintenance Heterozygote x Wild-type [C57BL/6JJcl]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Kit
Symbol name kit oncogene
Chromosome 5
Common name No Data
Symbol description No Data
References not yet determined

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
未定
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Sasaoka, Toshikuni (Niigata university) Sasaoka, Toshikuni
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months