RBRC02484, B6.Cg-B6.Cg-Hras1<tm1Mok> Nras<tm1Mok> Tg(HRAS/floxed)1Mok

RBRC No. RBRC02484
Type Targeted Mutation and TransgeneCartagena
Species Mus musculus
Strain name B6.Cg-B6.Cg-Hras1<tm1Mok> Nras<tm1Mok> Tg(HRAS/floxed)1Mok
Former Common name H-ras, N-ras double KO, L-Tg, B6-Hras KO/Nras KO/HRASfloxed Tg
H-2 Haplotype No Data
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Motoya Katsuki, National Institutes of Natural Sciences.
Strain description Hras knockout, Nras knockout and Lras transgenic triple mutant mice.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Nras
Symbol name neuroblastoma ras oncogene
Chromosome 3
Common name N-ras
Symbol description No Data
2 Symbol Csde1
Symbol name cold shock domain containing E1, RNA binding
Chromosome 3
Common name No Data
Symbol description No Data
3 Symbol Hras
Symbol name Harvey rat sarcoma virus oncogene
Chromosome 7
Common name c-H-ras, c-rasHa, H-ras, Ha-ras, Harvey-ras, Hras-1, ras
Symbol description No Data
4 Symbol neo
Symbol name No Data
Chromosome 7
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
5 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 3
Common name neo; neomycin;
Symbol description No Data
References Oncogene. 2000 Jun 15;19(26):2951-6.

Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis.
Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Oncogene, 19, 2951-2956 (2000). EMBO J., 21, 1021-1030 (2000).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Sasaoka, Toshikuni (Niigata university) Sasaoka, Toshikuni
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02586, C.Cg-Hras<tm1Mok>

RBRC No. RBRC02586
Type Targeted MutationCartagena
Species Mus musculus
Strain name C.Cg-Hras<tm1Mok>
Former Common name H-ras KO-BALB, BALB-Hras KO
H-2 Haplotype No Data
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Motoya Katsuki, National Institutes of Natural Sciences (Institute of Medical Science, University of Tokyo).
Strain description Hras gene knockout mice. BALB/c background.
Colony maintenance Heterozygote x Wild-type [or Crossing to BALB/cByJJcl]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name No Data
Chromosome No Data
Common name No Data
Symbol description No Data
References Oncogene. 2000 Jun 15;19(26):2951-6.

Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Oncogene,19, 2951-2956 (2000).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Sasaoka, Toshikuni (Niigata university) Sasaoka, Toshikuni
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC01083, B6.129S-Drd4<tm1Mok>

RBRC No. RBRC01083
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129S-Drd4<tm1Mok>
Former Common name D4R KO, B6-D4R KO
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Motoya Katsuki, National Institutes of Natural Sciences.
Strain description D4R (Drd4) gene knockout mice. Homozygous mutant mice show no obvious abnormality.
Colony maintenance Heterozygote x Wild-type [C57BL/6JJcl]
Health Report
Gene Details
Promoter No Data
1 Symbol Drd4
Symbol name dopamine receptor 4
Chromosome 7
Common name D4R, Drd-4
Symbol description No Data
2 Symbol Ecogpt
Symbol name E.coli xanthine phosphoribosyltransferase
Chromosome 7
Common name No Data
Symbol description No Data
Promoter mouse RNA polymerase II large subunit promoter
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 7
Common name neo; neomycin;
Symbol description No Data
References not yet determined

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
未定
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Sasaoka, Toshikuni (Niigata university) Sasaoka, Toshikuni
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC02377, B6;129S4-Cav3<tm1Ncnp>/177

RBRC No. RBRC02377
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129S4-Cav3<tm1Ncnp>/177
Former Common name cav3-KO/177, Cav3 KO#177
H-2 Haplotype No Data
ES cell line J1 [129S4/SvJae]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Toshikuni Sasaoka, National Institutes of Natural Sciences (National Institute of Neuroscience, National Center of Neurology and Psychiatry).
Strain description Cav3 (Caveolin 3) gene knockout mice. Cav3 is a muscle-specific form of the caveolin family proteins, which are small molecular weight proteins shown to be associated with the caveolar plasma membrane. Homozygous mutant mice show mid myopathic changes in muscle from 8 weeks ages. Viable and fertile. Line 177 (C57BL/6 background) (RBRC02374), Line 32 (mixed background) (RBRC02375), Line 142 (mixed background), Line 177 (mixed background) (RBRC02377).
Colony maintenance Homozygote x Heterozygote [or Crossing to C57BL/6JJcl]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Cav3
Symbol name caveolin 3
Chromosome 6
Common name Cav-3, M-caveolin
Symbol description No Data
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 6
Common name neo; neomycin;
Symbol description No Data
References

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Hum. Mol. Genet., 9, 3047-3054 (2000).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Toshikuni Sasaoka is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Sasaoka, Toshikuni (National Institute for Basic Biology) Sasaoka, Toshikuni
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02450, C3.Cg-Hras1<tm1Mok>/Q

RBRC No. RBRC02450
Type Targeted Mutation CongenicCartagena
Species Mus musculus
Strain name C3.Cg-Hras1<tm1Mok>/Q
Former Common name H-ras/Q-KO C3H/HeJ Jcl, C3H-Hras KO/Q
H-2 Haplotype No Data
Background strain C3H/HeJJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Motoya Katsuki, National Institutes of Natural Sciences (Institute of Medical Science, University of Tokyo).
Strain description Hras gene knockout mice (Line Q). C3H background.
Colony maintenance Heterozygote x Wild-type [or Crossing to C3H/HeJJcl]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Hras
Symbol name Harvey rat sarcoma virus oncogene
Chromosome 7
Common name c-H-ras, c-rasHa, H-ras, Ha-ras, Harvey-ras, Hras-1, ras
Symbol description No Data
2 Symbol neo
Symbol name No Data
Chromosome 7
Common name No Data
Symbol description No Data
References Oncogene. 2000 Jun 15;19(26):2951-6.

Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Oncogene, 19, 2951-2956 (2000).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Sasaoka, Toshikuni (Niigata university) Sasaoka, Toshikuni
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02469, B6.Cg-Prnp<tm1(PRNP)Tkik>

RBRC No. RBRC02469
Type Targeted Mutation CongenicCartagena
Species Mus musculus
Strain name B6.Cg-Prnp<tm1(PRNP)Tkik>
Former Common name B6-PRNP KO
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Motoya Katsuki, National Institutes of Natural Sciences (Institute of Medical Science, University of Tokyo).
Strain description Prnp gene-human PRNP knock-in mice.
Colony maintenance Heterozygote x Wild-type [C57BL/6JJcl]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name No Data
Chromosome No Data
Common name No Data
Symbol description No Data
References

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Biochem. Biophys. Res. Commun., 222, 742-747 (1996).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Sasaoka, Toshikuni (Niigata university) Sasaoka, Toshikuni
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02485, B6.Cg-Hras1<tm1Mok> Nras<tm1Mok> Kras<tm1Mok> Tg(HRAS/floxed)1Mok

RBRC No. RBRC02485
Type Targeted Mutation and TransgeneCartagena
Species Mus musculus
Strain name B6.Cg-Hras1<tm1Mok> Nras<tm1Mok> Kras<tm1Mok> Tg(HRAS/floxed)1Mok
Former Common name H-ras, N-ras, K-ras triple KO, L-Tg, B6-Hras KO/Nras KO/Kras KO/HRASfloxed Tg
H-2 Haplotype No Data
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Motoya Katsuki, National Institutes of Natural Sciences.
Strain description Hras knockout, Nras knockout, Kras knockout and Lras transgenic multiple mutant mice.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Nras
Symbol name neuroblastoma ras oncogene
Chromosome 3
Common name No Data
Symbol description No Data
2 Symbol Csde1
Symbol name cold shock domain containing E1, RNA binding
Chromosome 3
Common name No Data
Symbol description No Data
3 Symbol Kras
Symbol name v-Ki-ras2 Kirsten rat sarcome viral oncogene homolog
Chromosome 6
Common name No Data
Symbol description No Data
4 Symbol Hras
Symbol name Harvey rat sarcoma virus oncogene
Chromosome 7
Common name No Data
Symbol description No Data
5 Symbol neo
Symbol name No Data
Chromosome 7
Common name No Data
Symbol description No Data
6 Symbol HRAS
Symbol name Harvey rat sarcoma virus oncogene (human)
Chromosome UN
Common name No Data
Symbol description No Data
7 Symbol loxP
Symbol name phage P1 loxP
Chromosome UN
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
8 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 3
Common name neo; neomycin;
Symbol description No Data
References Oncogene. 1997 Sep 4;15(10):1151-9.
Oncogene. 2000 Jun 15;19(26):2951-6.

K-ras is essential for the development of the mouse embryo.
K-ras is essential for the development of the mouse embryo.
K-ras is essential for the development of the mouse embryo.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Oncogene, 19, 2951-2956 (2000). EMBO J., 21, 1021-1030 (2000). Oncogene, 15, 1151-1159 (1997).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Sasaoka, Toshikuni (Niigata university) Sasaoka, Toshikuni
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02598, B6;129-Mutyh<tm1Yun>

RBRC No. RBRC02598
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129-Mutyh<tm1Yun>
Former Common name MYH KO
H-2 Haplotype No Data
ES cell line CCE28 [129/Sv]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Yusaku Nakabeppu, Medical Institute of Bioregulation, Kyushu University. CCE28 ES cells derived from 129/Sv were used to generate the knockout mice. The mice were crossed to C57BL/6.
Strain description MYH (Mutyh) gene knockout mice. Exons 8 to 15 were replaced with a pol II neo cassette. Homozygous mutant mice show decreased susceptibility to neuronal excitotoxicity.
Colony maintenance Heterozygote x Wild-type [C57BL/6JJcl]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Mutyh
Symbol name mutY homolog (E. coli)
Chromosome 4
Common name No Data
Symbol description No Data
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 4
Common name No Data
Symbol description No Data
References

Research applications Neurobiology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Biol. Chem., 278, 38121-38124 (2003).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Sasaoka, Toshikuni (Niigata university) Sasaoka, Toshikuni
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC01084, B6.129-Drd5<tm1Mok>

RBRC No. RBRC01084
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6.129-Drd5<tm1Mok>
Former Common name D5R KO, B6-D5R KO
H-2 Haplotype No Data
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]
Background strain C57BL/6
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Motoya Katsuki, National Institutes of Natural Sciences.
Strain description D5R (Drd5) gene knockout mice. Homozygous mutant mice show no obvious abnormality.
Colony maintenance Heterozygote x Wild-type [C57BL/6JJcl]
Health Report
Gene Details
Promoter No Data
1 Symbol Drd5
Symbol name dopamine receptor 5
Chromosome 5
Common name Drd-5, DRD1b, Drd1b, Gpcr1
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 5
Common name neo; neomycin;
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
3 Symbol Ecogpt
Symbol name E.coli xanthine phosphoribosyltransferase
Chromosome 5
Common name No Data
Symbol description No Data
References not yet determined

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
未定
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 Genetic Background
2 Genotyping protocol <PCR>
Depositor Sasaoka, Toshikuni (Niigata university) Sasaoka, Toshikuni
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC02419, B6.Cg-Drd1a<tm1Mok> Drd2<tm1Mok>

RBRC No. RBRC02419
Type Targeted Mutation CongenicCartagena
Species Mus musculus
Strain name B6.Cg-Drd1a<tm1Mok> Drd2<tm1Mok>
Former Common name D1RD2R KO, B6-D1R/D2R KO
H-2 Haplotype No Data
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Motoya Katsuki, National Institutes of Natural Sciences.
Strain description D1R (Drd1a) and D2R (Drd2) genes double knockout mice.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Drd2
Symbol name dopamine receptor D2
Chromosome 9
Common name D2 receptor, D2R, Drd-2
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 13
Common name neo; neomycin;
Symbol description No Data
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 9
Common name neo; neomycin;
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
4 Symbol Drd1
Symbol name dopamine receptor D1
Chromosome 13
Common name C030036C15Rik, D1 receptor, Drd-1, Drd1, Gpcr15
Symbol description No Data
5 Symbol Ecogpt
Symbol name E.coli xanthine phosphoribosyltransferase
Chromosome 13
Common name No Data
Symbol description No Data
References Genes Cells. 1996 Feb;1(2):253-68.

Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary.
Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Neurosci., 28, 13390-13400 (2008). Genes Cells, 1, 253-268 (1996).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Sasaoka, Toshikuni (Niigata university) Sasaoka, Toshikuni
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months