RBRC01120, B6.Cg-Agt<tm1Afu>/AfuRbrc

RBRC No. RBRC01120
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6.Cg-Agt<tm1Afu>/AfuRbrc
Former Common name AGT-KO (BL/6)
H-2 Haplotype No Data
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Donor strain (C57BL/6 x CBA)F1 via TT2 ES cell line
Background strain C57BL/6JJcl
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Dr. Tanimoto K., University of Tsukuba in 2004. C57BL/6 background.
Strain description B6.B6CB-Agt<tm1Afu>. Homozygous mutant mice do not produce angiotensinogen in the liver, resulting in the complete loss of plasma immunoreactive angiotensin I. The systolic blood pressure of the homozygous mutant is lower than wild-type, demonstrates an indispensable role for the renin-angiotensin system in maintaining blood pressure.
Colony maintenance Sibling Mating (Heterozygote x Wild-type)
Homozygous mutant mice of C57BL/6 background show a low survivability. About 70 percent of homozygous mice
Health Report
Gene Details
Promoter No Data
1 Symbol Agt
Symbol name Angiotensinogen
Chromosome 8
Common name Aogen
Symbol description No Data
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 8
Common name neo; neomycin;
Symbol description No Data
References J Biol Chem. 1994 Dec 16;269(50):31334-7.

Angiotensinogen-deficient mice with hypotension.
Research applications Cell Biology Research,
Hematological Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Biol. Chem., 269, 31334-31337 (1994).
Additional information
1 Lab HP (Japanese)
2 Genotyping protocol <PCR>
Depositor Fukamizu, Akiyoshi (University of Tsukuba) Fukamizu, Akiyoshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC01121, B6.Cg-Ren1<tm1Afu>/AfuRbrc

RBRC No. RBRC01121
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.Cg-Ren1<tm1Afu>/AfuRbrc
Former Common name REN-KO (BL/6)
H-2 Haplotype No Data
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Donor strain (C57BL/6 x CBA)F1 via TT2 ES cell line
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Dr. Keiji Tanimoto, University of Tsukuba in 2003. C57BL/6 background.
Strain description B6.Cg-Ren1<tm1Afu>. Renin plays an essential role in the control of blood pressure through its specific leavage of angiotensinogen to generate angiotensin I. Homozygous mutant mice exhibit lowered blood pressure, increased urine and drinking volume, and altered renal morphology.
Colony maintenance Sibling Mating (Heterozygote x Heterozygote, Wild-type)
Homozygous mutant mice lowered blood pressure and die within a week after birth.
Health Report
Gene Details
Promoter No Data
1 Symbol Ren1
Symbol name renin 1 structural
Chromosome 1
Common name Ren, Ren-1, Ren-A, Ren1d, Rn-1, Rnr
Symbol description No Data
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 1
Common name neo; neomycin;
Symbol description No Data
3 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 1
Common name No Data
Symbol description E. coli beta galactosidase
References J Biol Chem. 2000 Jan 7;275(1):5-8.

Renin-dependent cardiovascular functions and renin-independent blood-brain barrier functions revealed by renin-deficient mice.
Research applications Cell Biology Research,
Hematological Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Biol. Chem., 275, 5-8 (2000).
Additional information
1 Lab HP (Japanese)
2 Genotyping protocol <PCR>
Depositor Fukamizu, Akiyoshi (University of Tsukuba) Fukamizu, Akiyoshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC01122, hRN 8-12

RBRC No. RBRC01122
Type Transgene CongenicCartagena wks
Species Mus musculus
Strain name hRN 8-12
Former Common name No Data
H-2 Haplotype No Data
Background strain C57BL/6J
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Dr. Akiyoshi Fukamizu, University of Tsukuba in 1991. C57BL/6 background.
Strain description Human renin gene transgenic mice with integration of 10 copies of a 15 kbp human DNA fragment containing the renin gene (hRN 8-12 mice). The renin-angiotensin system (RAS) is one of the determinant factors in regulating blood pressure and sodium absorption. RAS has been shown to accelerate various diseases such as renal failure, atherosclerosis, cardiac hypertrophy, and pulmonary hypertension. The reaction between renin, produced in the kidney, and its substrate angiotensinogen, produced in the liver, is the initial and rate-limiting step in the enzymatic cascade that generates angiotensin I. Angiotensin-converting enzyme in the lung converts angiotensin I to the potent vasoconstrictor angiotensin II (Ang II). The depositor reported that overactivation of the RAS induces hypertension in the F1 generation obtained from breeding between a female carrying the human renin gene (hRN+/+) and a male possessing the human angiotensinogen gene (hAG+/+). Moreover, female hAG+/+ mice when bred with male hRN+/+ mice are hypertensive specifically in late pregnancy, suggesting possible implications for preeclampsia or pregnancy-induced hypertension, a life-threatening disorder for human mothers and fetuses. hRN+/+ and hANG+/+ mice provide the opportunity to understand the role of the RAS in hypertension and other common diseases. hRN8-12 mice (RBRC01122), hAG 2-5 mice (RBRC01123), hRN8-12 x hAG2-5)F1 mice (RBRC02432).
Colony maintenance Carrier x Carrier (Homozygote x Homozygote) Homozygous mice are viable and fertile.
Health Report
Gene Details
Promoter No Data
1 Symbol REN1
Symbol name renin 1 structural (human)
Chromosome UN
Common name Ren, Ren-1, Ren-A, Ren1d, Rn-1, Rnr
Symbol description No Data
References Biochem Biophys Res Commun. 1989 Dec 15;165(2):826-32.

Tissue-specific expression of the human renin gene in transgenic mice.
Research applications Cell Biology Research,
Hematological Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Biochemical and Biophysical Research Communications, 165, 826-832 (1989).
Additional information
1 Lab HP (Japanese)
2 Mouse of the Month May 2012
Systolic blood pressure
Genetic Background
3 Genotyping protocol <PCR>
Depositor Fukamizu, Akiyoshi (University of Tsukuba) Fukamizu, Akiyoshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

Live
Live mouse :
BRC mice in Publications
Title Journal
(PMID)
Author
Exaggeration of focal cerebral ischemia in transgenic mice carrying human Renin and human angiotensinogen genes. Stroke.40(2): 597-603 (2009).(19023100)
Inaba S, Iwai M, Tomono Y, Senba I, Furuno M, Kanno H, Okayama H, Mogi M, Higaki J, Horiuchi M.
Continuous activation of renin-angiotensin system impairs cognitive function in renin/angiotensinogen transgenic mice. Hypertension.53(2): 356-62 (2009).(19047580)
Inaba S, Iwai M, Furuno M, Tomono Y, Kanno H, Senba I, Okayama H, Mogi M, Higaki J, Horiuchi M.
Exercise training can attenuate preeclampsia-like features in an animal model. J Hypertens.28(12): 2446-53 (2010).(20811291)
Falcao S, Bisotto S, Michel C, Lacasse AA, Vaillancourt C, Gutkowska J, Lavoie JL.
Impaired post-infarction cardiac remodeling in chronic kidney disease is due to excessive renin release. Lab Invest. (2012).(22986786)
Ogawa M, Suzuki JI, Takayama K, Senbonmatsu T, Hirata Y, Nagai R, Isobe M.

RBRC01123, hAG 2-5

RBRC No. RBRC01123
Type Transgene CongenicCartagena wks
Species Mus musculus
Strain name hAG 2-5
Former Common name No Data
H-2 Haplotype No Data
Background strain C57BL/6J
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Dr. Akiyoshi Fukamizu, University of Tsukuba in 1991. C57BL/6 background.
Strain description Human angiotensinogen gene transgenic mice with integration of 100 copies of a 14 kbp human DNA fragment containing the angiotensinogen gene (hAG 2-5 mice). The renin-angiotensin system (RAS) is one of the determinant factors in regulating blood pressure and sodium absorption. RAS has been shown to accelerate various diseases such as renal failure, atherosclerosis, cardiac hypertrophy, and pulmonary hypertension. The reaction between renin, produced in the kidney, and its substrate angiotensinogen, produced in the liver, is the initial and rate-limiting step in the enzymatic cascade that generates angiotensin I. Angiotensin-converting enzyme in the lung converts angiotensin I to the potent vasoconstrictor angiotensin II (Ang II). The depositor reported that overactivation of the RAS induces hypertension in the F1 generation obtained from breeding between a female carrying the human renin gene (hRN+/+) and a male possessing the human angiotensinogen gene (hAG+/+). Moreover, female hAG+/+ mice when bred with male hRN+/+ mice are hypertensive specifically in late pregnancy, suggesting possible implications for preeclampsia or pregnancy-induced hypertension, a life-threatening disorder for human mothers and fetuses. hRN+/+ and hANG+/+ mice provide the opportunity to understand the role of the RAS in hypertension and other common diseases. hRN8-12 mice (RBRC01122), hAG 2-5 mice (RBRC01123), hRN8-12 x hAG2-5)F1 mice (RBRC02432).
Colony maintenance Carrier x Carrier (Homozygote x Homozygote) Homozygous mice are viable and fertile.
Health Report
Gene Details
Promoter No Data
1 Symbol AGT
Symbol name Angiotensinogen (human)
Chromosome UN
Common name No Data
Symbol description No Data
References Biochem Biophys Res Commun. 1991 Oct 31;180(2):1103-9.

Expression of the human angiotensinogen gene in transgenic mice and transfected cells.
Research applications Cell Biology Research,
Hematological Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Biochemical and Biophysical Research Communications, 180, 1103-1109 (1991).
Within a period of 2 years after deposition of the material, user must contact bailor and notify him a content of the research. If the bailor judges that the research should be a collaborative work, then user must include bailor and/or developer’s names as co-authors.
Additional information
1 Lab HP (Japanese)
2 Mouse of the Month May 2012
Systolic blood pressure
Genetic Background
3 Genotyping protocol <PCR>
Depositor Fukamizu, Akiyoshi (University of Tsukuba) Fukamizu, Akiyoshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Live
Live mouse :
BRC mice in Publications
Title Journal
(PMID)
Author
Impaired post-infarction cardiac remodeling in chronic kidney disease is due to excessive renin release. Lab Invest. (2012).(22986786)
Ogawa M, Suzuki JI, Takayama K, Senbonmatsu T, Hirata Y, Nagai R, Isobe M.

RBRC01387, B6.Cg-Ncdn<tm2Afu>/AfuRbrc

RBRC No. RBRC01387
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.Cg-Ncdn<tm2Afu>/AfuRbrc
Former Common name NClox/lox
H-2 Haplotype No Data
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Donor strain (C57BL/6 x CBA)F1 via TT2 ES cell line
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Ncdn
Symbol name Neurochondrin
Chromosome 4
Common name mKIAA0607, neurochondrin-1, neurochondrin-2, norbin
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 4
Common name No Data
Symbol description No Data
3 Symbol loxP
Symbol name phage P1 loxP
Chromosome 4
Common name No Data
Symbol description No Data
References J Biol Chem. 2005 May 27;280(21):20503-8. Epub 2005 Mar 24.

Neurochondrin negatively regulates CaMKII phosphorylation, and nervous system-specific gene disruption results in epileptic seizure.
Research applications Cre/loxP system
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Biol. Chem., 21, 20503-20508 (2005).
Additional information
1 Lab HP (Japanese)
2 Genotyping protocol <PCR>
Depositor Fukamizu, Akiyoshi (University of Tsukuba) Fukamizu, Akiyoshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC01497, B6.Cg-Ncdn<tm2.1Afu>/AfuRbrc

RBRC No. RBRC01497
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6.Cg-Ncdn<tm2.1Afu>/AfuRbrc
Former Common name NC-/-
H-2 Haplotype No Data
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Donor strain (C57BL/6 x CBA)F1 via TT2 ES cell line
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Ncdn
Symbol name Neurochondrin
Chromosome 4
Common name mKIAA0607, neurochondrin-1, neurochondrin-2, norbin
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 4
Common name No Data
Symbol description No Data
References J Biol Chem. 2005 May 27;280(21):20503-8. Epub 2005 Mar 24.

Neurochondrin negatively regulates CaMKII phosphorylation, and nervous system-specific gene disruption results in epileptic seizure.
Research applications Cre/loxP system
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Biol. Chem., 21, 20503-20508 (2005).
Additional information
1 Lab HP (Japanese)
Depositor Fukamizu, Akiyoshi (University of Tsukuba) Fukamizu, Akiyoshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02432, (hRN8-12 x hAG2-5)F1

RBRC No. RBRC02432
Type TransgeneCartagena
Species Mus musculus
Strain name (hRN8-12 x hAG2-5)F1
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Dr. Akiyoshi Fukamizu, University of Tsukuba in 1991. C57BL/6 background.
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol AGT
Symbol name Angiotensinogen (human)
Chromosome UN
Common name No Data
Symbol description No Data
2 Symbol REN1
Symbol name renin 1 structural (human)
Chromosome UN
Common name No Data
Symbol description No Data
References Biochem Biophys Res Commun. 1989 Dec 15;165(2):826-32.
Biochem Biophys Res Commun. 1991 Oct 31;180(2):1103-9.

Tissue-specific expression of the human renin gene in transgenic mice.
Tissue-specific expression of the human renin gene in transgenic mice.
Research applications Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Biochemical and Biophysical Research Communications, 165, 826-832 (1989).
Biochemical and Biophysical Research Communications, 180, 1103-1109 (1991).
Additional information
1 Lab HP (Japanese)
2 Mouse of the Month May 2012
Systolic blood pressure
3 Genotyping protocol <PCR>
Depositor Fukamizu, Akiyoshi (University of Tsukuba) Fukamizu, Akiyoshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Live
Live mouse :
BRC mice in Publications
Title Journal
(PMID)
Author
Angiotensin II- and Salt-Induced Kidney Injury through Rac1-Mediated Mineralocorticoid Receptor Activation. J Am Soc Nephrol. (2012).(22440899)
Kawarazaki W, Nagase M, Yoshida S, Takeuchi M, Ishizawa K, Ayuzawa N, Ueda K, Fujita T.
Effects of aging and uninephrectomy on renal changes in Tsukuba hypertensive mice. Biomed Rep.1(3): 359-364 (2013).(24648949)
Inui Y, Mochida H, Yamairi F, Okada M, Ishida J, Fukamizu A, Arakawa K.
Suppressive effects of RXR agonist PA024 on adrenal CYP11B2 expression, aldosterone secretion and blood pressure. PLoS ONE12(8): e0181055 (2017).(28800627)
Suzuki D, Saito-Hakoda A, Ito R, Shimizu K, Parvin R, Shimada H, Noro E, Suzuki S, Fujiwara I, Kagechika H, Rainey WE, Kure S, Ito S, Yokoyama A, Sugawara A.

RBRC04696, B6;B6CB-Agtr1a<tm1Afu>

RBRC No. RBRC04696
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;B6CB-Agtr1a<tm1Afu>
Former Common name B6-AT1a KO
H-2 Haplotype No Data
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Agtr1a
Symbol name angiotensin II receptor, type 1a; targeted mutation 1, Akiyoshi Fukamizu
Chromosome 13
Common name No Data
Symbol description No Data
2 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 13
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 13
Common name No Data
Symbol description No Data
References

Research applications Cell Biology Research,
Fluorescent Proteins/lacZ System,
Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Biol. Chem., 270, 18719-18722 (1995).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
We are grateful to Professor Akiyoshi Fukamizu for providing ATla knock mice.
Additional information
1 Lab HP (Japanese)
2 Genotyping protocol <PCR>
Depositor Fukamizu, Akiyoshi (University of Tsukuba) Fukamizu, Akiyoshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC01115, ICR.Cg-Tg(hAGT-BAC)1Afu/AfuRbrc

RBRC No. RBRC01115
Type TransgeneCartagena
Species Mus musculus
Strain name ICR.Cg-Tg(hAGT-BAC)1Afu/AfuRbrc
Former Common name line 97-WT; hAGT-BAC-TgM (WT)
H-2 Haplotype No Data
Background strain ICR
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol AGT
Symbol name Angiotensinogen (human)
Chromosome UN
Common name No Data
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome UN
Common name No Data
Symbol description No Data
3 Symbol loxP
Symbol name phage P1 loxP
Chromosome UN
Common name No Data
Symbol description No Data
References

Research applications Cell Biology Research,
Hematological Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Mol. Cell. Biol., 25, 2938-2945 (2005).
Additional information
1 Lab HP (Japanese)
Depositor Fukamizu, Akiyoshi (University of Tsukuba) Fukamizu, Akiyoshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC01116, ICR.Cg-Tg(deltaC AGT-BAC)1Afu/AfuRbrc

RBRC No. RBRC01116
Type TransgeneCartagena
Species Mus musculus
Strain name ICR.Cg-Tg(deltaC AGT-BAC)1Afu/AfuRbrc
Former Common name line 97-Delta C; hAGT-BAC-TgM (Delta C)
H-2 Haplotype No Data
Background strain ICR
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol AGT
Symbol name Angiotensinogen (human)
Chromosome UN
Common name No Data
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome UN
Common name No Data
Symbol description No Data
3 Symbol loxP
Symbol name phage P1 loxP
Chromosome UN
Common name No Data
Symbol description No Data
References

Research applications Cell Biology Research,
Hematological Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Mol. Cell. Biol., 25, 2938-2945 (2005).
Additional information
1 Lab HP (Japanese)
Depositor Fukamizu, Akiyoshi (University of Tsukuba) Fukamizu, Akiyoshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months