RBRC02388, B6.129P2-Ly96<tm1Kmiy>

RBRC No. RBRC02388
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129P2-Ly96<tm1Kmiy>
Former Common name C57BL/6-MD-2 KO
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Ly96
Symbol name lymphocyte antigen 96
Chromosome 1
Common name ESOP-1, MD-2, MD2
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 1
Common name neo; neomycin;
Symbol description No Data
References Nat Immunol. 2002 Jul;3(7):667-72. Epub 2002 Jun 10.

Essential role of MD-2 in LPS responsiveness and TLR4 distribution.
Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Nature Immunology, 3, 667-672 (2002).
Additional information
1 Lab HP (Japanese)
2 Genotyping protocol <PCR>
Depositor Miyake, Kensuke (The Institute of Medical Science, The University of Tokyo) Miyake, Kensuke
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
MD-2 as the target of a novel small molecule, L6H21, in the attenuation of LPS-induced inflammatory response and sepsis. Br. J. Pharmacol.172(17): 4391-4405 (2015).(26076332)
Wang Y, Shan X, Chen G, Jiang L, Wang Z, Fang Q, Liu X, Wang J, Zhang Y, Wu W, Liang G.
MD2 Blockage Protects Obesity-Induced Vascular Remodeling via Activating AMPK/Nrf2. Obesity (Silver Spring)25(9): 1532-1539 (2017).(28726347)
Wang L, Han J, Shan P, You S, Chen X, Jin Y, Wang J, Huang W, Wang Y, Liang G.
Blockade of myeloid differentiation protein 2 prevents obesity-induced inflammation and nephropathy. J. Cell. Mol. Med. (2017).(28767204)
Fang Q, Wang L, Yang D, Chen X, Shan X, Zhang Y, Lum H, Wang J, Zhong P, Liang G, Wang Y.
Inhibition of myeloid differentiation factor-2 attenuates obesity-induced cardiomyopathy and fibrosis. Biochim. Biophys. Acta1864(1): 252-262 (2017).(28965884)
Fang Q, Wang J, Zhang Y, Wang L, Li W, Han J, Huang W, Liang G, Wang Y.
Inhibition of MD2-dependent inflammation attenuates the progression of non-alcoholic fatty liver disease. J. Cell. Mol. Med. (2017).(29077272)
Zhang Y, Wu B, Zhang H, Ge X, Ying S, Hu M, Li W, Huang Y, Wang L, Chen C, Shan X, Liang G.
Myeloid differentiation protein 2 induced retinal ischemia reperfusion injury via upregulation of ROS through a TLR4-NOX4 pathway. Toxicol. Lett.282: 109-120 (2017).(29111459)
Chen H, Song Z, Ying S, Yang X, Wu W, Tan Q, Ju X, Wu W, Zhang X, Qu J, Wang Y.

RBRC02389, C.129P2(B6)-Cd180<tm1Kmiy>

RBRC No. RBRC02389
Type Targeted MutationCartagena
Species Mus musculus
Strain name C.129P2(B6)-Cd180<tm1Kmiy>
Former Common name Balb/c-RP105 KO
H-2 Haplotype No Data
ES cell line E14.1 [129P2/OlaHsd]
Background strain BALB/cCrSlc
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Cd180
Symbol name CD180 antigen
Chromosome 13
Common name Ly78, RP105
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 13
Common name neo; neomycin;
Symbol description No Data
References

Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Exp. Med., 204, 2963-2976 (2007).
Additional information
1 Lab HP (Japanese)
2 Genotyping protocol <PCR>
Depositor Miyake, Kensuke (The Institute of Medical Science, The University of Tokyo) Miyake, Kensuke
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC02390, B6.129P2-Cd180<tm1Kmiy>

RBRC No. RBRC02390
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129P2-Cd180<tm1Kmiy>
Former Common name C57BL/6-RP105 KO
H-2 Haplotype No Data
ES cell line E14.1 [129P2/OlaHsd]
Background strain C57BL/6NCrSlc
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Cd180
Symbol name CD180 antigen
Chromosome 13
Common name Ly78, RP105
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 13
Common name neo; neomycin;
Symbol description No Data
References

Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Exp. Med., 204, 2963-2976 (2007).
Additional information
1 Lab HP (Japanese)
2 Mouse of the Month Oct 2015
3 Genotyping protocol <PCR>
Depositor Miyake, Kensuke (The Institute of Medical Science, The University of Tokyo) Miyake, Kensuke
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC02399, C57BL/6-PRAT4A<tm1Kmiy>

RBRC No. RBRC02399
Type Targeted MutationCartagena
Species Mus musculus
Strain name C57BL/6-PRAT4A<tm1Kmiy>
Former Common name C57BL/6-PRAT4A<-/->
H-2 Haplotype No Data
Background strain C57BL/6NCrSlc
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Dr. Kensuke Miyake, The University of Tokyo in 2000.
Strain description C57BL/6-PRAT4A<tm1Kmiy>. Immune cells such as dendric cells (DCs) and macrophages express multiple Toll-like receptors (TLRs) which recognize a variety of pathogen products. A protein associated with TLR4 (PRAT4A) has been found to bind TLR4, and regulate the expression of TLR4 and the response to LPS. Using PRAT4A-deficient mice, there are defective cytokine production against bacteria and activation of Th1 responses. DCs, macrophages and B cells lacking PRAT4A have impaired responses to a variety of TLR ligands. The PRAT4A-deficient bone marrow chimera mice are resistant to lethal-dose LPS administration in the LPS-induced sepsis model to analyze in vivo immune response. This mutant mouse is useful for the study of PRAT4A in innate and adaptive immunity.
Colony maintenance Heterozygote x Wild-type [C57BL/6CrSlc]
Health Report
Gene Details
Promoter No Data
1 Symbol Cnpy3
Symbol name canopy 3 homolog (zebrafish)
Chromosome 17
Common name 1600025D17Rik, 2410050O22Rik, CAG4A, ERDA5, Tnrc5
Symbol description No Data
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 17
Common name neo; neomycin;
Symbol description No Data
References J Exp Med. 2007 Nov 26;204(12):2963-76. Epub 2007 Nov 6.

A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses.
Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Exp. Med., 204, 2963-2976 (2007).
Transfer of the BIOLOGICAL RESOURCE to the third party from the RECIPIENT will never be done without a prior permission of the DEPOSITOR.
The RECIPIENT shall inform the DEPOSITOR about the purpose of the use of the BIOLOGICAL RESOURCE.
The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 Lab HP (Japanese)
2 Mouse of the Month Apr 2008
3 Genotyping protocol <PCR>
Depositor Miyake, Kensuke (The Institute of Medical Science, The University of Tokyo) Miyake, Kensuke
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC02728, MRL.Cg-Fas<lpr> Cd180<tm1Kmiy>

RBRC No. RBRC02728
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name MRL.Cg-Fas<lpr> Cd180<tm1Kmiy>
Former Common name MRL-lpr/lpr RP105-/-, MRL-lpr/lpr Cd180
H-2 Haplotype No Data
ES cell line E14.1 [129P2/OlaHsd]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Cd180
Symbol name CD180 antigen
Chromosome 13
Common name Ly78, RP105
Symbol description No Data
2 Symbol Fas
Symbol name Fas (TNF receptor superfamily member)
Chromosome 19
Common name APO-1, CD95, TNFR6, Tnfrsf6
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 13
Common name neo; neomycin;
Symbol description No Data
References Int Immunol. 2008 Jul;20(7):881-91. Epub 2008 May 19.

Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice.
Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Int. Immunol., 20(7):881-891 (2008).
The RECIPIENT must contact the DEPOSITOR in the case of application for any patents use with the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 Lab HP (Japanese)
Depositor Miyake, Kensuke (The Institute of Medical Science, The University of Tokyo) Miyake, Kensuke
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02729, NZB.Cg-Cd180<tm1Kmiy>

RBRC No. RBRC02729
Type Targeted MutationCartagena
Species Mus musculus
Strain name NZB.Cg-Cd180<tm1Kmiy>
Former Common name NZB-RP105-/-
H-2 Haplotype No Data
ES cell line E14.1 [129P2/OlaHsd]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Cd180
Symbol name CD180 antigen
Chromosome 13
Common name Ly78, RP105
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 13
Common name neo; neomycin;
Symbol description No Data
References Int Immunol. 2008 Jul;20(7):881-91. Epub 2008 May 19.

Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice.
Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Int. Immunol., 20(7):881-891 (2008).
The RECIPIENT must contact the DEPOSITOR in the case of application for any patents use with the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 Lab HP (Japanese)
2 Genotyping protocol <PCR>
Depositor Miyake, Kensuke (The Institute of Medical Science, The University of Tokyo) Miyake, Kensuke
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02730, NZW.Cg-Cd180<tm1Kmiy>

RBRC No. RBRC02730
Type Targeted MutationCartagena
Species Mus musculus
Strain name NZW.Cg-Cd180<tm1Kmiy>
Former Common name NZW-RP105-/-
H-2 Haplotype No Data
ES cell line E14.1 [129P2/OlaHsd]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Cd180
Symbol name CD180 antigen
Chromosome 13
Common name Ly78, RP105
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 13
Common name neo; neomycin;
Symbol description No Data
References Int Immunol. 2008 Jul;20(7):881-91. Epub 2008 May 19.

Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice.
Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Int. Immunol., 20(7):881-891 (2008).
The RECIPIENT must contact the DEPOSITOR in the case of application for any patents use with the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 Lab HP (Japanese)
2 Genotyping protocol <PCR>
Depositor Miyake, Kensuke (The Institute of Medical Science, The University of Tokyo) Miyake, Kensuke
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC04929, B6;129P2(129)-Unc93b1<tm1.1(D34A)Kmiy>

RBRC No. RBRC04929
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129P2(129)-Unc93b1<tm1.1(D34A)Kmiy>
Former Common name Unc93b1/D34A KI
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Kensuke Miyake, The Institute of Medical Science, The University of Tokyo in 2008.
Strain description No Data
Colony maintenance Heterozygote x Wild-type
Health Report
Gene Details
Promoter No Data
1 Symbol Unc93b1
Symbol name unc-93 homolog B1 (C. elegans)
Chromosome 19
Common name No Data
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 19
Common name No Data
Symbol description No Data
References

Research applications Cre/loxP system,
Metabolism Research,
Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Immunity, 35, 69-81 (2011).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents use with the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 Mouse of the Month Jul 2011
2 Lab HP (Japanese)
3 Genotyping protocol <PCR>
Depositor Miyake, Kensuke (The Institute of Medical Science, The University of Tokyo) Miyake, Kensuke
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC04930, B6.129P2(129)-Unc93b1<tm1.1(D34A)Kmiy>

RBRC No. RBRC04930
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129P2(129)-Unc93b1<tm1.1(D34A)Kmiy>
Former Common name B6-Unc93b1/D34A KI
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Kensuke Miyake, The Institute of Medical Science, The University of Tokyo in 2008.
Strain description No Data
Colony maintenance Heterozygote x Wild-type [C57BL/6NCrSlc]
Health Report
Gene Details
Promoter No Data
1 Symbol Unc93b1
Symbol name unc-93 homolog B1 (C. elegans)
Chromosome 19
Common name No Data
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 19
Common name No Data
Symbol description No Data
References

Research applications Cre/loxP system,
Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Immunity, 35, 69-81 (2011).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents use with the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 Lab HP (Japanese)
2 Mouse of the Month Jul 2011
Genetic Background
Depositor Miyake, Kensuke (The Institute of Medical Science, The University of Tokyo) Miyake, Kensuke
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC04931, C.129P2(Cg)-Unc93b1<tm1.1(D34A)Kmiy>

RBRC No. RBRC04931
Type Targeted MutationCartagena
Species Mus musculus
Strain name C.129P2(Cg)-Unc93b1<tm1.1(D34A)Kmiy>
Former Common name BALB-Unc93b1/D34A KI
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Kensuke Miyake, The Institute of Medical Science, The University of Tokyo in 2008.
Strain description No Data
Colony maintenance Heterozygote x Wild-type [or Crossing to BALB/cCrSlc]
Health Report
Gene Details
Promoter No Data
1 Symbol Unc93b1
Symbol name unc-93 homolog B1 (C. elegans)
Chromosome 19
Common name No Data
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 19
Common name No Data
Symbol description No Data
References

Research applications Cre/loxP system,
Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Immunity, 35, 69-81 (2011).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents use with the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 Lab HP (Japanese)
2 Mouse of the Month Jul 2011
Genetic Background
3 Click Here for Mouse genomic DNA (RIKEN DNA Bank)
Depositor Miyake, Kensuke (The Institute of Medical Science, The University of Tokyo) Miyake, Kensuke
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months