RBRC01772, B6.129S2-Tmbim1<tm1Noj>/41

RBRC No. RBRC01772
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6.129S2-Tmbim1<tm1Noj>/41
Former Common name RECS1 KO
H-2 Haplotype No Data
ES cell line D3 [129S2/SvPas]
Background strain C57BL/6
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Hanjun Zhao, Norikazu Yabuta and Hiroshi Nojima, Research Institute for Microbial Diseases, Osaka University in 2001. D3 ES cells were used to generate the knockout mice. The mutant mice were backcrossed to C57BL/6 over 8 times.
Strain description RECS1 (Tmbim1) gene knockout mice. The 5'-untranslated sequence (-3.8 kb) and exon 1-6 region of RECS1 was replaced by PGK-neo cassette. Homozygous mutant mice are prone to aortic dilation and cystic medial degeneration (CMD) when the mice ages (older than 14 months). Aortic dilation and CMD are frequently encountered. Viable and fertile.
Colony maintenance Heterozygote x Homozygote [or Crossing to C57BL/6NCrSlc]
Health Report
Gene Details
Promoter No Data
1 Symbol Tmbim1
Symbol name transmembrane BAX inhibitor motif containing 1
Chromosome 1
Common name RECS1
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 1
Common name neo; neomycin;
Symbol description No Data
References Genes Genet Syst. 2006 Feb;81(1):41-50.

RECS1 deficiency in mice induces susceptibility to cystic medial degeneration.
Research applications Cardiovascular Research,
Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
RECS1 deficiency in mice induces susceptibility to cystic medical degeneration. Hanjun Zhao et al. (2006) Genes Genet. Syst. 81, p41-50
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 Mouse of the Month Jan 2007
2 Genotyping protocol <PCR>
Depositor Nojima, Hiroshi (Osaka university) Nojima, Hiroshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC01773, B6;129S2-Tmbim1<tm1Noj>/26

RBRC No. RBRC01773
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129S2-Tmbim1<tm1Noj>/26
Former Common name RECS1 KO
H-2 Haplotype No Data
ES cell line D3 [129S2/SvPas]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Hanjun Zhao, Norikazu Yabuta and Hiroshi Nojima, Research Institute for Microbial Diseases, Osaka University in 2001. D3 ES cells were used to generate the knockout mice.
Strain description RECS1 (Tmbim1) gene knockout mice. The 5'-untranslated sequence (-3.8 kb) and exon 1-6 region of RECS1 was replaced by PGK-neo cassette. Homozygous mutant mice are prone to aortic dilation and cystic medial degeneration (CMD) when the mice ages (older than 14 months). Aortic dilation and CMD are frequently encountered. Viable and fertile.
Colony maintenance Heterozygote x Homozygote [or Crossing to C57BL/6NCrSlc]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Tmbim1
Symbol name transmembrane BAX inhibitor motif containing 1
Chromosome 1
Common name RECS1
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 1
Common name neo; neomycin;
Symbol description No Data
References Genes Genet Syst. 2006 Feb;81(1):41-50.

RECS1 deficiency in mice induces susceptibility to cystic medial degeneration.
Research applications Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
RECS1 deficiency in mice induces susceptibility to cystic medical degeneration. Hanjun Zhao et al. (2006) Genes Genet. Syst. 81, p41-50
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 Mouse of the Month Jan 2007
2 Genotyping protocol <PCR>
Depositor Nojima, Hiroshi (Osaka university) Nojima, Hiroshi
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC01841, B6.Cg-Tg(hGOS2)3Noj

RBRC No. RBRC01841
Type TransgeneCartagena wks
Species Mus musculus
Strain name B6.Cg-Tg(hGOS2)3Noj
Former Common name AILE1 TG (ATG3)
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Norikazu Yabuta and Hiroshi Nojima, Research Institute for Microbial Diseases, Osaka University in 2004. The transgene was injected into the pronuclei of B6D2F1 fertilized eggs. C57BL/6 and DBA/2 mixed (B6 semicongenic).
Strain description These transgenic mice express human GOS2 (AILE1) gene that was a gene identified as systemic lupus erythematosus (SLE)-upregutated gene by microarray screening.
Colony maintenance Carrier x Noncarrier [C57BL/6NCrSlc]
Health Report No Data
Gene Details
Promoter CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)
1 Symbol AILE1
Symbol name augmented expression in SLE
Chromosome UN
Common name No Data
Symbol description No Data
References DNA Res. 2005;12(6):429-39. Epub 2006 Feb 23.

Isolation and expression profiling of genes upregulated in the peripheral blood cells of systemic lupus erythematosus patients.
Isolation and expression profiling of genes upregulated in the peripheral blood cells of systemic lupus erythematosus patients.
Research applications Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
DNA Res., 12, 429-439 (2005).
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 No Data
Depositor Nojima, Hiroshi (Osaka university) Nojima, Hiroshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC01903, B6;129S2-Lats2<tm1Noj>

RBRC No. RBRC01903
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129S2-Lats2<tm1Noj>
Former Common name Tats2 heterozygous (He) mouse
H-2 Haplotype No Data
ES cell line D3 [129S2/SvPas]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Norikazu Yabuta and Hiroshi Nojima, Research Institute for Microbial Diseases, Osaka University in 2002. D3 ES cells were used. The mutant mice were crossed to C57BL/6.
Strain description Lats2 gene knockout mice. The first coding exon was replaced with a PGK-neo cassette. Homozygous mutant mice are embryonic lethal.
Colony maintenance Heterozygote x Wild-type [C57BL/6NCrSlc]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Lats2
Symbol name large tumor suppressor 2
Chromosome 14
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 14
Common name neo; neomycin;
Symbol description No Data
References J Biol Chem. 2007 May 3;.

Lats2 is an essential mitotic regulator required for the coordination of cell division.
Research applications Cell Biology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J Biol Chem., 282, 19259-19271 (2007).
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Nojima, Hiroshi (Osaka university) Nojima, Hiroshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC01942, B6;129S2-Creb3l4<tm1Noj>

RBRC No. RBRC01942
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6;129S2-Creb3l4<tm1Noj>
Former Common name Tisp40 KO mouse
H-2 Haplotype No Data
ES cell line D3 [129S2/SvPas]
Background strain No Data
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Norikazu Yabuta and Hiroshi Nojima, Research Institute for Microbial Diseases, Osaka University in 2004. D3 ES cells were used. The mutant mice were crossed to C57BL/6 over 6 times.
Strain description TISP40 (Creb3l4) gene knockout mice. Exons 5 to 10 were replaced with a neo cassette. Homozygous mutant mice are viable and fertile.
Colony maintenance Heterozygote x Homozygote [or Crossing to C57BL/6NCrSlc]
Health Report
Gene Details
Promoter No Data
1 Symbol Creb3l4
Symbol name cAMP responsive element binding protein 3-like 4
Chromosome 3
Common name 1700012K17Rik, 5330432F22Rik, ATCE1, CREB3, CREB4, JAL, mJAL, Tisp40, Tisp40alpha, Tisp40beta
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 3
Common name neo; neomycin;
Symbol description No Data
References Genes Cells. 2006 Oct;11(10):1161-71.

The testes-specific bZip type transcription factor Tisp40 plays a role in ER stress responses and chromatin packaging during spermiogenesis.
Research applications Cell Biology Research,
Reproductive Biology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Genes to Cells, 11, 1161-1171 (2006).
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Nojima, Hiroshi (Osaka university) Nojima, Hiroshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Tisp40 deficiency attenuates renal ischemia reperfusion injury induced apoptosis of tubular epithelial cells. Exp. Cell Res.359(1): 138-144 (2017).(28778797)
Qin C, Xiao C, Su Y, Zheng H, Xu T, Lu J, Luo P, Zhang J.
Tisp40 deficiency limits renal inflammation and promotes tubular cell proliferation in renal ischemia reperfusion injury. Exp. Cell Res. (2018).(30121191)
Qin C, Li M, Bai T, Yang K, Xu T, Zhang J.

RBRC01952, B6;129S2-Lats1<tm1Noj>

RBRC No. RBRC01952
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6;129S2-Lats1<tm1Noj>
Former Common name Lats1 heterozygous (He) mouse
H-2 Haplotype No Data
ES cell line D3 [129S2/SvPas]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Norikazu Yabuta and Hiroshi Nojima, Research Institute for Microbial Diseases, Osaka University in 2004. D3 ES cells were used. The mutant mice were crossed to C57BL/6.
Strain description Lats1 gene knockout mice (deltaN type). Exon 1 containing a translation initiation codon was replaced with a PGK-neo cassette. Homozygous mutant mice are small. Homozygous mutant females cannot nurse pups due to lacking mammae.
Colony maintenance Heterozygote x Wild-type [C57BL/6NCrSlc]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Lats1
Symbol name large tumor suppressor
Chromosome 10
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 10
Common name neo; neomycin;
Symbol description No Data
References

Research applications Cell Biology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J CellSci., 126, 508-520 (2013).
The RECIPIENT agrees to use of this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 No Data
Depositor Nojima, Hiroshi (Osaka university) Nojima, Hiroshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC02315, B6;129S2-Ccng2<tm1Noj>/+

RBRC No. RBRC02315
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129S2-Ccng2<tm1Noj>/+
Former Common name CyclinG2+/- (Cyclin G2 heterozygous mouse)
H-2 Haplotype No Data
ES cell line D3 [129S2/SvPas]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Norikazu Yabuta and Hiroshi Nojima, Research Institute for Microbial Diseases, Osaka University in 2007. D3 ES cells were used. The mutant mice were crossed to C57BL/6.
Strain description Cyclin G2 (Ccng2) gene knockout mice. Exons 2 to 4 were replaced with a PGK-neo cassette. Homozygous mutant mice are viable and fertile.
Colony maintenance Heterozygote x Wild-type [C57BL/6NCrSlc]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Ccng2
Symbol name cyclin G2
Chromosome 5
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 5
Common name neo; neomycin;
Symbol description No Data
References

Research applications Cell Biology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
Cell Cycle., 12, 1773-1784 (2013).
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 No Data
Depositor Nojima, Hiroshi (Osaka university) Nojima, Hiroshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC02342, C57BL/6-Gak<tm1Noj>/+

RBRC No. RBRC02342
Type Targeted MutationCartagena
Species Mus musculus
Strain name C57BL/6-Gak<tm1Noj>/+
Former Common name GAK+/-, Cyclin G-associated kinase(GAK) heterozygous mouse
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Norikazu Yabuta and Hiroshi Nojima, Research Institute for Microbial Diseases, Osaka University in 2007.
Strain description Gak, cyclin G associated kinase gene knockout mice. Exons 2-4 of Gak gene were replaced with a pgk-neo cassette. Homozygous mutant mice die shortly after birth.
Colony maintenance Heterozygote x Wild-type [or Crossing to C57BL/6JJcl]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Gak
Symbol name cyclin G associated kinase
Chromosome 5
Common name D130045N16Rik, MGC:31204, GAK-kd
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 5
Common name neo; neomycin;
Symbol description No Data
References

Research applications Cancer Research,
Cell Biology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Tabara H et al., “Neonatal lethality in knockout mice expressing the kinase-dead form of the gefitinib target GAK is caused by pulmonary dysfunction.” PLoS One 2011;6(10):e26034
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 No Data
Depositor Nojima, Hiroshi (Osaka university) Nojima, Hiroshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC03984, B6.Cg-Ccng1<tm2Noj> Ccng2<tm1Noj>/NojRbrc

RBRC No. RBRC03984
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.Cg-Ccng1<tm2Noj> Ccng2<tm1Noj>/NojRbrc
Former Common name Cyclin G1<+/-> ;Cyclin G2<+/-> [Cyclin G1; Cyclin G2 double heterozygous mouse]
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Ccng1
Symbol name cyclin G1
Chromosome 11
Common name No Data
Symbol description No Data
2 Symbol Ccng2
Symbol name cyclin G2
Chromosome 5
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 11
Common name neo; neomycin;
Symbol description No Data
4 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 5
Common name neo; neomycin;
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
後日指定
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Nojima, Hiroshi (Osaka university) Nojima, Hiroshi
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months