|Former Common name||DTR-9.6 kb Tg|
|H-2 Haplotype||No Data|
|Genotype||a/a B/B C/C|
|Strain development||Developed by Drs. Tatsumi and Ikeda, National Center for Geriatrics and Gerontology in 2003.|
|Strain description||Bone remodeling consists of two distinct stages, resorption and formation, which are performed by osteoclasts and osteoblasts, respectively. Dmp1-HBEGF transgenic mice express human HB-EGF as the receptor for diphtheria toxin (DT) on the cell surface of osteocytes under the control of Dmp1 promoter. Most of the osteocytes (70 to 80%) can be ablated in these transgenic mice by injection of DT. The osteocytes-ablated mice develop osteoporosis, even in young age, showing fragile bone with intracortical porosity and microfractures, osteoblastic dysfunction, and loss of trabecular bone with microstructural deterioration and adipose tissue proliferation in the marrow space. Interestingly, the mice do not respond to mechanical unloading with bone loss. This strain is a useful model for the study of osteoporosis and mechanotransduction in bone.|
|Colony maintenance||Backcross to C57BL/6 (Hemizygote x C57BL/6CrSlc)|
|Promoter||Dmp1 (dentin matrix protein 1) promoter|
|Symbol name||heparin-binding EGF-like growth factor (human)|
|Common name||No Data|
|Symbol description||No Data|
|References||Cell Metab. 2007 Jun;5(6):464-75.
Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction.
|Research applications||Mouse Models for Human Disease|
|Specific Term and Conditions||The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Cell Metab., 6, 464-475, (2007).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
|1||Mouse of the Month Oct 2007|
|2||Genotyping protocol <PCR>|
|Depositor||Ikeda, Kyoji (National Center for Geriatrics and Gerontology)|
|Strain Status /
|Skeletal adaptation to intramedullary pressure-induced interstitial fluid flow is enhanced in mice subjected to targeted osteocyte ablation.||PLoS One.7(3): e33336 (2012).(22413015)|
|Kwon RY, Meays DR, Meilan AS, Jones J, Miramontes R, Kardos N, Yeh JC, Frangos JA.|
|The Role of Osteocytes in Bone Resorption during Orthodontic Tooth Movement.||J Dent Res. (2013).(23358677)|
|Matsumoto T, Iimura T, Ogura K, Moriyama K, Yamaguchi A.|