RBRC02380, B6;129S-Zfhx2<tm3Ymri>

RBRC No. RBRC02380
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129S-Zfhx2<tm3Ymri>
Former Common name S5-KO
H-2 Haplotype No Data
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Zfhx2
Symbol name zinc finger homeobox 2
Chromosome 14
Common name zfh-5
Symbol description No Data
2 Symbol GFP
Symbol name Green Fluorescent Protein (Jellyfish)
Chromosome 14
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 14
Common name neo; neomycin;
Symbol description No Data
References No Data

Research applications Fluorescent Proteins/lacZ System,
Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Mol. Cell. Neurosci., 31, 273-283 (2006).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR and a citation of the following literature(s) designated by the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE. Transfer of the BIOLOGICAL RESOURCE to the third party from the RECIPIENT will never be done without a prior permission of the DEPOSITOR.
Additional information
1 GFP Transfer License (Japanese / English)
Please fill in the Schedule A, and submit two signed copies to us together with two signed copies of RIKEN BRC’s MTA. Please also read Schedule B.
Depositor Yamamori, Tetsuo (National Institutes for Basic Research) Yamamori, Tetsuo
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02381, B6;129S-Zfhx2as<tm1Ymri>

RBRC No. RBRC02381
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129S-Zfhx2as<tm1Ymri>
Former Common name AS-KO
H-2 Haplotype No Data
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Zfhx2os
Symbol name zinc finger homeobox 2, opposite strand
Chromosome 14
Common name zfh-5 antisense
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 14
Common name neo; neomycin;
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Mol. Cell. Neurosci., 31, 273-283 (2006).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR and a citation of the following literature(s) designated by the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE. Transfer of the BIOLOGICAL RESOURCE to the third party from the RECIPIENT will never be done without a prior permission of the DEPOSITOR.
Additional information
1 No Data
Depositor Yamamori, Tetsuo (National Institutes for Basic Research) Yamamori, Tetsuo
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02261, B6.129S-Zfhx2<tm2Ymri>

RBRC No. RBRC02261
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129S-Zfhx2<tm2Ymri>
Former Common name S4-KO (C57BL/6J)
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 14
Common name neo; neomycin;
Symbol description No Data
2 Symbol Zfhx2
Symbol name zinc finger homeobox 2
Chromosome 14
Common name zfh-5
Symbol description No Data
3 Symbol GFP
Symbol name Green Fluorescent Protein (Jellyfish)
Chromosome 14
Common name No Data
Symbol description No Data
References No Data

Research applications Fluorescent Proteins/lacZ System,
Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Mol. Cell. Neurosci., 31, 273-283 (2006).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR and a citation of the following literature(s) designated by the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE. Transfer of the BIOLOGICAL RESOURCE to the third party from the RECIPIENT will never be done without a prior permission of the DEPOSITOR.
Additional information
1 GFP Transfer License (Japanese / English)
Please fill in the Schedule A, and submit two signed copies to us together with two signed copies of RIKEN BRC’s MTA. Please also read Schedule B.
Depositor Yamamori, Tetsuo (National Institutes for Basic Research) Yamamori, Tetsuo
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

Live
Live mouse :

RBRC02262, B6.129S-Zfhx2<tm3Ymri>

RBRC No. RBRC02262
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129S-Zfhx2<tm3Ymri>
Former Common name S5-KO (C57BL/6J)
H-2 Haplotype No Data
ES cell line E14 [129P2/OlaHsd]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Tetsuo Yamamori, National Institute for Basic Biology. E14 ES cells were used. The mutant mice were backcrossed to C57BL/6J. S5 line.
Strain description Zfhx2 knockout mice. Exons 2 to 6 were replaced with a EGFP-pA and TK-neo-pA cassettes.
Marsili syndrome is caused by a point mutation in ZFHX2 gene. The Marsili syndrome is a human Mendelian disorder and the symptom is insensitivity to pain. Zfhx2-global knockout mice also show the unusual pain perception phenotype.
Health Report
Gene Details
Promoter No Data
1 Symbol Zfhx2
Symbol name zinc finger homeobox 2
Chromosome 14
Common name zfh-5
Symbol description No Data
2 Symbol GFP
Symbol name Green Fluorescent Protein (Jellyfish)
Chromosome 14
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 14
Common name neo; neomycin;
Symbol description No Data
References No Data

Research applications Fluorescent Proteins/lacZ System,
Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Mol. Cell. Neurosci., 31, 273-283 (2006).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR and a citation of the following literature(s) designated by the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE. Transfer of the BIOLOGICAL RESOURCE to the third party from the RECIPIENT will never be done without a prior permission of the DEPOSITOR.
Additional information
1 GFP Transfer License (Japanese / English)
Please fill in the Schedule A, and submit two signed copies to us together with two signed copies of RIKEN BRC’s MTA. Please also read Schedule B.
2 Genotyping protocol <PCR>
Depositor Yamamori, Tetsuo (National Institutes for Basic Research) Yamamori, Tetsuo
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
A novel human pain insensitivity disorder caused by a point mutation in ZFHX2. Brain.141(2): 365-376. (2018).(29253101)
Habib AM, Matsuyama A, Okorokov AL, Santana-Varela S, Bras JT, Aloisi AM, Emery EC, Bogdanov YD, Follenfant M, Gossage SJ, Gras M, Humphrey J, Kolesnikov A, Le Cann K, Li S, Minett MS, Pereira V, Ponsolles C, Sikandar S, Torres JM, Yamaoka K, Zhao J, Komine Y, Yamamori T, Maniatis N, Panov KI, Houlden H, Ramirez JD, Bennett DLH, Marsili L, Bachiocco V, Wood JN, Cox JJ.

RBRC02263, C.129S-Zfhx2<tm2Ymri>

RBRC No. RBRC02263
Type Targeted MutationCartagena
Species Mus musculus
Strain name C.129S-Zfhx2<tm2Ymri>
Former Common name S4-KO (BALB/cA Jcl)
H-2 Haplotype No Data
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Zfhx2
Symbol name zinc finger homeobox 2
Chromosome 14
Common name zfh-5
Symbol description No Data
2 Symbol No Data
Symbol name SV40 polyA
Chromosome 14
Common name No Data
Symbol description No Data
3 Symbol GFP
Symbol name Green Fluorescent Protein (Jellyfish)
Chromosome 14
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
4 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 14
Common name neo; neomycin;
Symbol description No Data
References No Data

Research applications Fluorescent Proteins/lacZ System,
Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Mol. Cell. Neurosci., 31, 273-283 (2006).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR and a citation of the following literature(s) designated by the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE. Transfer of the BIOLOGICAL RESOURCE to the third party from the RECIPIENT will never be done without a prior permission of the DEPOSITOR.
Additional information
1 GFP Transfer License (Japanese / English)
Please fill in the Schedule A, and submit two signed copies to us together with two signed copies of RIKEN BRC’s MTA. Please also read Schedule B.
Depositor Yamamori, Tetsuo (National Institutes for Basic Research) Yamamori, Tetsuo
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC02264, C.129S-Zfhx2<tm3Ymri>

RBRC No. RBRC02264
Type Targeted MutationCartagena
Species Mus musculus
Strain name C.129S-Zfhx2<tm3Ymri>
Former Common name S5-KO (BALB/cA Jcl)
H-2 Haplotype No Data
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Zfhx2
Symbol name zinc finger homeobox 2
Chromosome 14
Common name zfh-5
Symbol description No Data
2 Symbol No Data
Symbol name SV40 polyA
Chromosome 14
Common name No Data
Symbol description No Data
3 Symbol GFP
Symbol name Green Fluorescent Protein (Jellyfish)
Chromosome 14
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
4 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 14
Common name neo; neomycin;
Symbol description No Data
References No Data

Research applications Fluorescent Proteins/lacZ System,
Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Mol. Cell. Neurosci., 31, 273-283 (2006).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR and a citation of the following literature(s) designated by the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE. Transfer of the BIOLOGICAL RESOURCE to the third party from the RECIPIENT will never be done without a prior permission of the DEPOSITOR.
Additional information
1 GFP Transfer License (Japanese / English)
Please fill in the Schedule A, and submit two signed copies to us together with two signed copies of RIKEN BRC’s MTA. Please also read Schedule B.
Depositor Yamamori, Tetsuo (National Institutes for Basic Research) Yamamori, Tetsuo
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC02265, B6.129S-Zfhx2as<tm1Ymri>

RBRC No. RBRC02265
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129S-Zfhx2as<tm1Ymri>
Former Common name AS-KO (C57BL/6J)
H-2 Haplotype No Data
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Zfhx2os
Symbol name zinc finger homeobox 2, opposite strand
Chromosome 14
Common name zfh-5 antisense
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 14
Common name neo; neomycin;
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Mol. Cell. Neurosci., 31, 273-283 (2006).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR and a citation of the following literature(s) designated by the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE. Transfer of the BIOLOGICAL RESOURCE to the third party from the RECIPIENT will never be done without a prior permission of the DEPOSITOR.
Additional information
1 No Data
Depositor Yamamori, Tetsuo (National Institutes for Basic Research) Yamamori, Tetsuo
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC02266, C.129S-Zfhx2as<tm1Ymri>

RBRC No. RBRC02266
Type Targeted MutationCartagena
Species Mus musculus
Strain name C.129S-Zfhx2as<tm1Ymri>
Former Common name AS-KO (BALB/cA Jcl)
H-2 Haplotype No Data
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Zfhx2os
Symbol name zinc finger homeobox 2, opposite strand
Chromosome 14
Common name zfh-5 antisense
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 14
Common name neo; neomycin;
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Mol. Cell. Neurosci., 31, 273-283 (2006).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR and a citation of the following literature(s) designated by the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE. Transfer of the BIOLOGICAL RESOURCE to the third party from the RECIPIENT will never be done without a prior permission of the DEPOSITOR.
Additional information
1 No Data
Depositor Yamamori, Tetsuo (National Institutes for Basic Research) Yamamori, Tetsuo
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC02379, B6;129S-Zfhx2<tm2Ymri>

RBRC No. RBRC02379
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129S-Zfhx2<tm2Ymri>
Former Common name S4-KO
H-2 Haplotype No Data
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Zfhx2
Symbol name zinc finger homeobox 2
Chromosome 14
Common name zfh-5
Symbol description No Data
2 Symbol GFP
Symbol name Green Fluorescent Protein (Jellyfish)
Chromosome 14
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 14
Common name neo; neomycin;
Symbol description No Data
References No Data

Research applications Fluorescent Proteins/lacZ System,
Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Mol. Cell. Neurosci., 31, 273-283 (2006).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR and a citation of the following literature(s) designated by the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE. Transfer of the BIOLOGICAL RESOURCE to the third party from the RECIPIENT will never be done without a prior permission of the DEPOSITOR.
Additional information
1 GFP Transfer License (Japanese / English)
Please fill in the Schedule A, and submit two signed copies to us together with two signed copies of RIKEN BRC’s MTA. Please also read Schedule B.
Depositor Yamamori, Tetsuo (National Institutes for Basic Research) Yamamori, Tetsuo
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months