RBRC04395, B6;129-Siglec1<tm1(HBEGF)Mtka>

RBRC No. RBRC04395
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129-Siglec1<tm1(HBEGF)Mtka>
Former Common name CD169-DTR KO
H-2 Haplotype No Data
ES cell line R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Masato Tanaka, RIKEN Research Center for Allergy and Immunology. R1 ES cells were used. C57BL/6 background.
Strain description CD169 (Siglec1) DTR knock-in mice. HB-EGF is expressed from CD169 locus.
Colony maintenance Homozygote x Homozygote [or Crossing to C57BL/6JJcl]
Health Report
Gene Details
Promoter No Data
1 Symbol Siglec1
Symbol name sialic acid binding Ig-like lectin 1, sialoadhesin
Chromosome 2
Common name No Data
Symbol description No Data
2 Symbol HBEGF
Symbol name heparin-binding EGF-like growth factor (human)
Chromosome 2
Common name No Data
Symbol description No Data
3 Symbol loxP
Symbol name phage P1 loxP
Chromosome 2
Common name No Data
Symbol description No Data
References J Clin Invest. 2007 Aug 1;117(8):2268-2278.

Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigens.
Research applications Cre/loxP system,
Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Nat. Biotechnol., 19, 746-750 (2001). J. Clin Invest., 117, 2268-2278 (2007).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. Kenji Kohno, Ph.D. and Masato Tanaka, Ph.D. The recipient shall obtain a prior written approval from the depositor.
Additional information
1 Mouse of the Month Dec 2012
Genetic Background
2 Genotyping protocol <PCR>
Depositor Tanaka, Masato (RIKEN Research Center For Allergy and Immunology) Tanaka, Masato
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

Live
Live mouse :
BRC mice in Publications
Title Journal
(PMID)
Author
Macrophage Subset Expressing CD169 in Peritoneal Cavity-Regulated Mucosal Inflammation Together with Lower Levels of CCL22. Inflammation40(4): 1191-1203 (2017).(28466432)
Wang D, Li Q, Yang Y, Hao S, Han X, Song J, Yin Y, Li X, Tanaka M, Qiu CH.
G-CSF mediates lung injury in mice with adenine-induced acute kidney injury. Int. Immunopharmacol.63: 1-8. (2018).(30056257)
Jing W, Qin F, Guo X, Sun Y, Yan C, Qiu C, Tanaka M, Shi B, Zhao Y.

RBRC04834, C57BL/6J-Slc7a11<m1Mtka>

RBRC No. RBRC04834
Type Chemically-induced Mutation
Species Mus musculus
Strain name C57BL/6J-Slc7a11<m1Mtka>
Former Common name xCT mutant
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Masato Tanaka, RIKEN Research Center for Allergy and Immunologuy in 2005. Generated by RIKEN ENU mutagenesis project.
Strain description Slc7a11 mutant mice generated by ENU mutagenesis. A transverstion of G to T in exon 10 was caused and results in a premature termination at position 383 glycine. Homozygous mutant mice exhibit decreased survival of LPS-induced macropgages and increase chemically-induced tumors.
Colony maintenance Heterozygote X Wild-type [C57BL/6JJcl] Homozygous mutant mice exhibit decreased survival of LPS-induced macropgages and increase chemically-induced tumors.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Slc7a11
Symbol name solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
Chromosome 3
Common name xCTmu
Symbol description No Data
References

Research applications Cancer Research,
Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Proc. Matl. Acad. Sci., USA, 107, 6436-6441(2010).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
A RECIPIENT shall obtain a prior written approval from the DEPOSITOR using approval form.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Tanaka, Masato (RIKEN Research Center For Allergy and Immunology) Tanaka, Masato
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC06239, C57BL/6-Siglec1<tm1(cre)Mtka>

RBRC No. RBRC06239
Type Targeted MutationCartagena
Species Mus musculus
Strain name C57BL/6-Siglec1<tm1(cre)Mtka>
Former Common name CD169-Cre, B6-Siglec1/Cre KI
H-2 Haplotype No Data
ES cell line D3 [129S2/SvPas]
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Dr. Masato Tanaka, Tokyo University of Pharmacy and Life Sciences, School of Life Science. B6JN/1 ES cells were used. C57BL/6 background.
Strain description CD169 (Siglec1) cre knock-in mice. iCre recombinase is expressed from CD169 locus.
Colony maintenance Heterozygote x Wild-type [C57BL/6JJcl]
Health Report
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name polyoma virus polyA
Chromosome 2
Common name No Data
Symbol description No Data
2 Symbol Siglec1
Symbol name sialic acid binding Ig-like lectin 1, sialoadhesin
Chromosome 2
Common name No Data
Symbol description No Data
3 Symbol iCre
Symbol name phage P1 codon improved Cre (iCre)
Chromosome 2
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
4 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 2
Common name No Data
Symbol description No Data
References Genesis, 19, (2002).

Research applications Cre/loxP system,
Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Am. Soc. Nephrol., 26, 896-906 (2015).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT agrees to use the BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR/DEVELOPER, and then include them as co-authors in any publications resulted by the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Tanaka, Masato (Tokyo University of Pharmacy and Life Sciences) Tanaka, Masato
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

Live
Live mouse :

RBRC06408, C;129(B6)-Siglec1<tm1(HBEGF)Mtka>

RBRC No. RBRC06408
Type Targeted MutationCartagena
Species Mus musculus
Strain name C;129(B6)-Siglec1<tm1(HBEGF)Mtka>
Former Common name CD169-DTR, BALB-Siglec1/DTR KI
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Masato Tanaka, RIKEN Research Center for Allergy and Immunology. R1 ES cells were used. The mutant mice were crossed to BALB/c over 5 times.
Strain description CD169 (Siglec1) DTR knock-in mice. HB-EGF is expressed from CD169 locus.
Colony maintenance Homozygote x Homozygote [or Crossing to BALB/cAJcl]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name No Data
Chromosome No Data
Common name No Data
Symbol description No Data
References J Clin Invest. 2007 Aug 1;117(8):2268-2278.

Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigens.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Nat. Biotechnol., 19, 746-750 ( 2001). J. Clin. Invest., 117, 2268-2278 (2007).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR/DEVELOPER (Masato Tanaka, Ph.D. and Kenji Kohno, Ph.D.) is requested.
Additional information
1 No Data
Depositor Tanaka, Masato (Tokyo University of Pharmacy and Life Sciences) Tanaka, Masato
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC10586, B6.Cg-Chil3<em1(Venus)Mtka>

RBRC No. RBRC10586
Type CRISPR/Cas9 (Transgene)Cartagena
Species Mus musculus
Strain name B6.Cg-Chil3<em1(Venus)Mtka>
Former Common name Ym1-Venus
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Chil3
Symbol name chitinase-like 3
Chromosome 3
Common name No Data
Symbol description No Data
2 Symbol Frt
Symbol name yeast FRT (flippase recombination target) site
Chromosome 3
Common name No Data
Symbol description No Data
3 Symbol Frt
Symbol name yeast FRT (flippase recombination target) site
Chromosome 3
Common name No Data
Symbol description No Data
4 Symbol HBB2
Symbol name Rabbit beta-globin polyA
Chromosome 3
Common name No Data
Symbol description No Data
5 Symbol Venus
Symbol name Green Fluorescent Protein, F46L (Jellyfish)
Chromosome 3
Common name No Data
Symbol description No Data
Promoter mouse Phosphoglycerate kinase promoter (PGK promoter), gb2 promoter
6 Symbol neo
Symbol name No Data
Chromosome 3
Common name No Data
Symbol description No Data
References No Data

Research applications FLP/frt system,
Fluorescent Proteins/lacZ System
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Ikeda et al. 2018 Science Immunology (PMID: 30291130, DOI: 10.1126/sciimmunol.aat0207.)
The recipient shall not distribute the biological resource to others without a written consent from the depositor. The RECIPIENT agrees to use the BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR/DEVELOPER (Masato Tanaka and Gen Nishitai). The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEVELOPER of the Venus using Approval form (form V) (Lab Contact: Laboratory for Cell Function Dynamics, RIKEN CBS: sakurai-h@brain.riken.jp).
Additional information
1 No Data
Depositor Tanaka, Masato (RIKEN Research Center For Allergy and Immunology) Tanaka, Masato
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

Live
Live mouse :

RBRC04394, B6;129-Lyz2<tm1(DTR)Mtka>

RBRC No. RBRC04394
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6;129-Lyz2<tm1(DTR)Mtka>
Former Common name LysM-DTR KI
H-2 Haplotype No Data
ES cell line R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Lyz2
Symbol name lysozyme 2
Chromosome 10
Common name No Data
Symbol description No Data
2 Symbol HBEGF
Symbol name heparin-binding EGF-like growth factor (human)
Chromosome 10
Common name No Data
Symbol description No Data
3 Symbol loxP
Symbol name phage P1 loxP
Chromosome 10
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
4 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 10
Common name neo; neomycin;
Symbol description No Data
References J Immunol. 2007 Apr 15;178(8):5001-9.

Protective Role of Macrophages in Noninflammatory Lung Injury Caused by Selective Ablation of Alveolar Epithelial Type II Cells.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Nat. Biotechnol., 19, 746-750 (2001). J. Immunol., 178, 5001-5009 (2007).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. Kenji Kohno,Ph.D., Masato Tanaka, Ph.D. The recipient shall obtain a prior written approval from the depositor.
Additional information
1 Mouse of the Month Apr 2011
2 Genotyping protocol <PCR>
Depositor Tanaka, Masato (RIKEN Research Center For Allergy and Immunology) Tanaka, Masato
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months