RBRC02277, Omphk(lacZ) (Acc. No. CDB0029K)

RBRC No. RBRC02277
Type Targeted MutationCartagena
Species Mus musculus
Strain name Omphk(lacZ) (Acc. No. CDB0029K)
Former Common name No Data
H-2 Haplotype No Data
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Nuak1
Symbol name NUAK family, SNF1-like kinase, 1
Chromosome 10
Common name B230104P22Rik
Symbol description No Data
2 Symbol Frt
Symbol name yeast FRT (flippase recombination target) site
Chromosome 10
Common name No Data
Symbol description No Data
3 Symbol Frt
Symbol name yeast FRT (flippase recombination target) site
Chromosome 10
Common name No Data
Symbol description No Data
4 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 10
Common name No Data
Symbol description E. coli beta galactosidase
5 Symbol lox71
Symbol name phage P1 loxP
Chromosome 10
Common name No Data
Symbol description No Data
6 Symbol loxP
Symbol name phage P1 loxP
Chromosome 10
Common name No Data
Symbol description No Data
7 Symbol poly A
Symbol name rabbit beta-globin polyA
Chromosome 10
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
8 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 10
Common name neo; neomycin;
Symbol description No Data
References Dev Dyn. 2006 Aug;235(8):2229-37.

A new serine/threonine protein kinase, Omphk1, essential to ventral body wall formation.
Research applications Cre/loxP system,
Developmental Biology Research,
FLP/frt system,
Fluorescent Proteins/lacZ System
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
(1) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Accession No. CDB0029K and the BIOLOGICAL RESOURCE is requested (http://www.cdb.riken.jp/arg/mutant%20mice%20list.html). (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested, Developmental Dynamics 235, 2229-2237 (2006). (3) Please inform the DEVELOPER (mutant@cdb.riken.jp) about the paper when published.
Additional information
1 No Data
Depositor RIKEN, CDB (RIKEN Center for Developmental Biology) RIKEN, CDB
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02857, B6.Cg-Vps52<tm1Kab>/20Rbrc

RBRC No. RBRC02857
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.Cg-Vps52<tm1Kab>/20Rbrc
Former Common name Vps52 #20(Acc.No.CDB0767K)
H-2 Haplotype No Data
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Michihiko Sugimoto and Kuniya Abe, RIKEN BioResource center in 2008. TT2 (B6CBF1 derived) ES cells were used to generate the targeted mice. C57BL/6 and CBA mixed (C57BL/6 semicongenic).
Strain description Vps52 2lox2frt (neo) targeted mice in which Frt-neo cassette (PGK-neo) was inserted upstream of exon 2, and two loxP sites were located in introns 1 and 2. Homozygous mutant mice were embryonic lethal. Line 95 (main line) (RBRC02794), Line 16 (sub line) (RBRC02832), Line 20 (sub line) (RBRC02857).
Colony maintenance Heterozygote x Wild-type [C57BL/6NCrlCrlj]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Vps52
Symbol name VPS52 GARP complex subunit
Chromosome 17
Common name No Data
Symbol description No Data
2 Symbol Frt
Symbol name yeast FRT (flippase recombination target) site
Chromosome 17
Common name No Data
Symbol description No Data
3 Symbol HBB2
Symbol name rabbit beta-globin
Chromosome 17
Common name No Data
Symbol description No Data
4 Symbol lox71
Symbol name mutant lox sequence
Chromosome 17
Common name No Data
Symbol description No Data
5 Symbol loxP
Symbol name phage P1 loxP
Chromosome 17
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
6 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 17
Common name neo; neomycin;
Symbol description No Data
References

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
(1) The RECIPIENT shall obtain a prior agreement from Dr. Kuniya Abe (abe@brc.riken.jp) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Acc.No. CDB0767K and Web. Site (http://www.cdb.riken.jp/arg/mutant%20mice%20list.html) is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested (Cell Rep. 2012 2(5):1363-74.). (4) Please inform the DEPOSITOR (mutant@cdb.riken.jp) about the paper when published.
Additional information
1 Lab HP
Depositor RIKEN, CDB (RIKEN Center for Developmental Biology) RIKEN, CDB
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC03514, Hrs(loxP)(Acc.No. CDB0476K)

RBRC No. RBRC03514
Type Targeted MutationCartagena
Species Mus musculus
Strain name Hrs(loxP)(Acc.No. CDB0476K)
Former Common name No Data
H-2 Haplotype No Data
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Frt
Symbol name yeast FRT (flippase recombination target) site
Chromosome 11
Common name No Data
Symbol description No Data
2 Symbol Hgs
Symbol name HGF-regulated tryosine kinase substrate
Chromosome 11
Common name No Data
Symbol description No Data
3 Symbol loxP
Symbol name phage P1 loxP
Chromosome 11
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
4 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 11
Common name No Data
Symbol description No Data
References Am J Pathol. 2008 Dec;173(6):1806-17. Epub 2008 Nov 13.

Loss of hrs in the central nervous system causes accumulation of ubiquitinated proteins and neurodegeneration.
Research applications Cre/loxP system,
FLP/frt system
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
(1) The RECIPIENT shall obtain a prior agreement from Nobuyuki Tanaka (tanaka@med.tohoku.ac.jp) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Accession No. (CDB0476K) (http:www.cdb.riken.jp/arg/mutant%20mice%20list.html) and the BIOLOGICAL RESOURCE is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested. (Am J Pathol. 2008 173(6):1806-17.) (4) Please inform the DEPOSITOR (mutant@cdb.riken.jp) about the paper when published.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor RIKEN, CDB (RIKEN Center for Developmental Biology) RIKEN, CDB
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC04801, B6.Cg-Kcp<tm1Ysas>/Rbrc

RBRC No. RBRC04801
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.Cg-Kcp<tm1Ysas>/Rbrc
Former Common name Kcp(tau-lacZ) (Acc.No.CDB0401K)
H-2 Haplotype No Data
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Dr. Yoshiki Sasai, Center for Developmental Biology, RIKEN.
Strain description This transgene contains tau-lacZ with a floxed neo in the first exon of Kcp to replace with lacZ at the first ATG. Kcp is a Kielin-related molecule that contains multiple Chd-type cysteine-rich repeats, a vWD domain and a TIL domain, and physically binds to Bmp proteins. Homozygous mutant mice are viable and fertile, and exhibit no gross structural defects.
Colony maintenance Heterozygote X Wild-type [C56BL/6] Homozygous mutant mice are viable and fertile.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Kcp
Symbol name kielin/chordin-like protein
Chromosome 6
Common name No Data
Symbol description No Data
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome No Data
Common name neo; neomycin;
Symbol description No Data
3 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome No Data
Common name No Data
Symbol description No Data
4 Symbol loxP
Symbol name phage P1 loxP
Chromosome No Data
Common name No Data
Symbol description No Data
5 Symbol poly A
Symbol name poly A
Chromosome No Data
Common name No Data
Symbol description No Data
6 Symbol tau
Symbol name bovine tau protein cDNA
Chromosome No Data
Common name No Data
Symbol description No Data
References Development. 2006 Nov;133(22):4463-73. Epub 2006 Oct 11.

Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis.
Research applications Cre/loxP system,
Fluorescent Proteins/lacZ System
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
(1) The RECIPIENT shall obtain a prior agreement from Dr. Yoshiki Kasai (yoshikikasai@cdb.riken.jp) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Accession No. CDB0401K, and Web Site (http:www.cdb.riken.jp/arg/mutant%20mice%20list.html) and the BIOLOGICAL RESOURCE is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested. (Development, 133, 4463-4473 (2006).) (4) Please inform the DEPOSITOR (mutant@cdb.riken.jp) about the paper when published.
Additional information
1 No Data
Depositor RIKEN, CDB (RIKEN Center for Developmental Biology) RIKEN, CDB
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC05279, I7(RDY)-ires-Nrp1-ires-gap-ECFP:IANC (Acc. No.CDB0449T)

RBRC No. RBRC05279
Type Targeted MutationCartagena
Species Mus musculus
Strain name I7(RDY)-ires-Nrp1-ires-gap-ECFP:IANC (Acc. No.CDB0449T)
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Hitoshi Sakano, Graduate School of Science, University of Tokyo.
Strain description A mutant-type odorant receptor, I7 (D126R/R127D), Neuropilin-1, and an axonal marker gene, gap-ECFP, are expressed under MOR23 (Olfr16) gene promoter.
Colony maintenance Carrier x Noncarrier [C57BL/6N]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name No Data
Chromosome No Data
Common name No Data
Symbol description No Data
References Science. 2009 Jul 31;325(5940):585-90. Epub 2009 Jul 9.

Pre-target axon sorting establishes the neural map topography.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
(1) The RECIPIENT shall obtain a prior agreement from the DEVELOPER (Dr. Hitoshi Sakano, The University of Tokyo, E-mail: sakano@mail.ecc.u-tokyo.ac.jp) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Acc.No. CDB0449T and Web. Site (http://www.cdb.riken.jp/arg/mutant%20mice%20list.html) is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested. (Science. 2009 325(5940):585-90.) (4) Please inform the DEPOSITOR (mutant@cdb.riken.jp) about the paper when published.
Additional information
1 GFP Transfer License (Japanese / English)
Please fill in the Schedule A, and submit two signed copies to us together with two signed copies of RIKEN BRC’s MTA. Please also read Schedule B.
Depositor RIKEN, CDB (RIKEN Center for Developmental Biology) RIKEN, CDB
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC06500, SJL.Cg-Aqp4<tm1.1(GFP)Mysi>/MysiRbrc

RBRC No. RBRC06500
Type Targeted MutationCartagena
Species Mus musculus
Strain name SJL.Cg-Aqp4<tm1.1(GFP)Mysi>/MysiRbrc
Former Common name SJL-Aqp4, KI/GFPdNeo#5, aquaporin 4 (GFP)-9 (Acc.No. CDB0758K-1)
H-2 Haplotype No Data
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Yoichiro Abe and Masato Yasui, Scholl of Medicine, Keio University. TT2 ES cells were used to generate the mutant mice. PGK-neo cassette was removed by crossing with B6-CAG-FLPe#37 mice. The mutant mice were backcrossed to SJL/J mice.
Strain description Aqp4 gene GFP knock-in mice. GFP was inserted into exon 1. Homozygous mutant mice are viable and fertile. SJL/J background.
Colony maintenance Homozygote x Homozygote [or Crossing to SJL/J(Crlj)]
Health Report
Gene Details
Promoter No Data
1 Symbol Aqp4
Symbol name aquaporin 4
Chromosome 18
Common name No Data
Symbol description No Data
2 Symbol EGFP
Symbol name Enhanced Green Fluorescent Protein, F64L and S65T (Jellyfish)
Chromosome 18
Common name No Data
Symbol description No Data
3 Symbol Frt
Symbol name yeast FRT (flippase recombination target) site
Chromosome 18
Common name No Data
Symbol description No Data
4 Symbol loxP
Symbol name phage P1 loxP
Chromosome 18
Common name No Data
Symbol description No Data
References

Research applications Cre/loxP system,
FLP/frt system,
Fluorescent Proteins/lacZ System
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
(1) The RECIPIENT shall obtain a prior agreement from Dr. Masato Yasui (myasui@a3.keio.jp) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Accession No. (CDB0758K-1) (http:www.cdb.riken.jp/arg/mutant%20mice%20list.html) and the BIOLOGICAL RESOURCE is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested. (未発表) (4) Please inform the DEPOSITOR (mutant@cdb.riken.jp) about the paper when published.
Additional information
1 GFP Transfer License (Japanese / English)
Please fill in the Schedule A, and submit two signed copies to us together with two signed copies of RIKEN BRC’s MTA. Please also read Schedule B.
2 Genotyping protocol <PCR>
Depositor RIKEN, CDB (RIKEN Center for Developmental Biology) RIKEN, CDB
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

RBRC09345, mpk2(Acc.No.CDB0435K)

RBRC No. RBRC09345
Type Targeted MutationCartagena
Species Mus musculus
Strain name mpk2(Acc.No.CDB0435K)
Former Common name No Data
H-2 Haplotype No Data
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name No Data
Chromosome No Data
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
(1) The RECIPIENT shall obtain a prior agreement from the DEVELOPER Dr. Naoto Ueno (National Institute for Basic Biology)(nueno@nibb.ac.jp) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Acc.No. CDB0435K and Web Site (www2.clst.riken.jp/arg/mutant%20mice%20list.html) is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested (Am J Hum Genet. 2011 88(2):138-49.). (4) Please inform the DEPOSITOR (mutant@cdb.riken.jp) about the paper when published.
Additional information
1 No Data
Depositor RIKEN, CDB (RIKEN Center for Developmental Biology) RIKEN, CDB
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02575, B6.Cg-Trp53<tm1Sia>/SiaRbrc

RBRC No. RBRC02575
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.Cg-Trp53<tm1Sia>/SiaRbrc
Former Common name p53(-) (Acc. No. CDB0001K)
H-2 Haplotype No Data
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Trp53
Symbol name transformation related protein 53
Chromosome 11
Common name p53
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 11
Common name neo; neomycin;
Symbol description No Data
References Oncogene. 1993 Dec;8(12):3313-22.

Enhanced proliferative potential in culture of cells from p53-deficient mice.
Research applications Cancer Research,
Cell Biology Research,
Immunology and Inflammation Research,
Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
(1) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Accession No. CDB0001K and the BIOLOGICAL RESOURCE is requested (http://www.cdb.riken.jp/arg/mutant%20mice%20list.html). (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested, Oncogene. 1993 Dec; 8 (12): 3313-22. (3) In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested, “We acknowledge Dr. AIZAWA in CDB for providing us the p53 mutant mice (Acc. No. CDB0001K).” (4) Please inform the DEVELOPER (mutant@cdb.riken.jp) about the paper when published.
Additional information
1 No Data
Depositor RIKEN, CDB (RIKEN Center for Developmental Biology) RIKEN, CDB
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC02983, B6.Cg-Emx2<tm1Sia>/SiaRbrc

RBRC No. RBRC02983
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.Cg-Emx2<tm1Sia>/SiaRbrc
Former Common name Emx2(-) (Acc. No. CDB0018K)
H-2 Haplotype No Data
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Emx2
Symbol name empty spiracles homolog 2 (Drosophila)
Chromosome 19
Common name No Data
Symbol description No Data
References

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Development, 124,101-111 (1997).
(1) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Accession No. CDB0018K and the BIOLOGICAL RESOURCE is requested (http://www.cdb.riken.jp/arg/mutant%20mice%20list.html). (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested. (3) Please inform the DEVELOPER (mutant@cdb.riken.jp) about the paper when published.
Additional information
1 No Data
Depositor RIKEN, CDB (RIKEN Center for Developmental Biology) RIKEN, CDB
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

RBRC03515, B6.Cg-Aire<tm2Mmat>/Rbrc

RBRC No. RBRC03515
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.Cg-Aire<tm2Mmat>/Rbrc
Former Common name Aire(GFP) (Acc.No. CDB0479K)
H-2 Haplotype No Data
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Developmental Biology and Mitsuru Matsumoto, Institute for Enzyme Research, University of Tokushima. TT2 ES cells were used.
Strain description Aire GFP knock-in mice. A GFP was inserted in the Aire gene locus between exon 1 and 2.
Health Report
Gene Details
Promoter No Data
1 Symbol Aire
Symbol name autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)
Chromosome 10
Common name No Data
Symbol description No Data
2 Symbol GFP
Symbol name Green Fluorescent Protein (Jellyfish)
Chromosome 10
Common name No Data
Symbol description No Data
3 Symbol loxP
Symbol name phage P1 loxP
Chromosome 10
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
4 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 10
Common name No Data
Symbol description No Data
References J Exp Med. 2008 Nov 24;205(12):2827-38. Epub 2008 Nov 17.

Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance.
Research applications Cre/loxP system,
Fluorescent Proteins/lacZ System
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
(1) The RECIPIENT shall obtain a prior agreement from Dr. Mitsuru Matsumoto (mitsuru@ier.tokushima-u.ac.jp) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Accession No. (CDB0479K) (http:www.cdb.riken.jp/arg/mutant%20mice%20list.html) and the BIOLOGICAL RESOURCE is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested. (J Exp Med. 2008 205(12):2827-38.) (4) Please inform the DEPOSITOR (mutant@cdb.riken.jp) about the paper when published.
Additional information
1 GFP Transfer License (Japanese / English)
Please fill in the Schedule A, and submit two signed copies to us together with two signed copies of RIKEN BRC’s MTA. Please also read Schedule B.
2 Genotyping protocol <PCR>
Depositor RIKEN, CDB (RIKEN Center for Developmental Biology) RIKEN, CDB
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months