RBRC10963, B6.129-Tg(Nanog-RFP)2Szki

RBRC No. RBRC10963
Type TransgeneCartagena
Species Mus musculus
Strain name B6.129-Tg(Nanog-RFP)2Szki
Former Common name Nanog-RFP Tg mouse
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development 寄託者によって作製され、2019年11月に論文として発表された。129系統マウス由来ES細胞からNanog-RFP Tg ES細胞株を樹立。これをC57BL/6Jマウスブラストシストにインジェクションし、キメラマウス作製工程を経て作製した。キメラマウスをC57BL/6Jと掛け合わせ、その後十世代以上C57BL/6Jに戻し交配されている。問題なく繁殖でき、特に異常等の表現型は観察されない。
Strain description Nanogの発現をRFPの蛍光で観察できるレポーターマウス。ただし、Nanogを発現するunipotentな始原生殖細胞では蛍光が観察されず、多能性幹細胞でだけ蛍光が観察される。
Health Report No Data
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name SV40 polyA
Chromosome UN
Common name No Data
Symbol description No Data
Promoter mouse Nanog promoter
2 Symbol RFP
Symbol name Discosoma sp. Red Fluorescent Protein
Chromosome UN
Common name No Data
Symbol description No Data
References No Data

Research applications Fluorescent Proteins/lacZ System
提供条件 条件を付加する。
利用者は提供承諾書を用いて、事前に寄託者の承諾を得る。
研究成果の公表にあたって寄託者の指定する文献を引用する。
Genesis, 57, e23334 (2019).
研究成果の公表にあたって謝辞の表明を必要とする。
営利目的利用の希望については、希望者は予め九州大学有体物理センターに連絡し、承認を得る。利用者は、上記の条件に加えて、九州大学が定めた条件の範囲で利用する。学術機関の学術研究に限る。 利用者が本件リソースを使用して得られた研究結果に基づき特許等の申請、及び事業活動を行う場合は、寄託者と別途協議を行う。
Additional information
1 No Data
Depositor 鈴木 淳史 (国立大学法人 九州大学 生体防御医学研究所) 鈴木 淳史
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
準備中につき、お問い合わせ下さい。
(提供までに6ヵ月以上を要する場合があります。)

Live
生体のまま:

RBRC10950, C57BL/6-Tg(CAG-Sphk1)H1Ytkw

RBRC No. RBRC10950
Type TransgeneCartagena
Species Mus musculus
Strain name C57BL/6-Tg(CAG-Sphk1)H1Ytkw
Former Common name Sphk1 transgenic mice (Tg line: High)
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development 開発者: 金沢大学·多久和 陽(2003年)C57BL/6系統の受精卵を用いて作出(トランスジーンをインジェクションにより導入)。C57BL/6系統。C57BL/6Jマウスとの交配により維持。TGマウス成獣において、下肢虚血後血管新生の亢進、および心筋線維症を呈する。
Strain description スフィンゴシンキナーゼ(sphingosine kinase: Sphk)は、脂質メディエータースフィンゴシン1-リン酸(S1P)産生の律速酵素であり、細胞内でスフィンゴシンをリン酸化することによってS1Pを産生する。また、SphKはS1PリアーゼによるS1P分解を介してスフィンゴ脂質をグリセロリン脂質代謝に結びつける役割も持つ。SphKには、SphK-1とSphK-2の二種のアイソフォームが存在する。このマウスは、CAGプロモーター制御下でSphingosine kinase-1(Sphk1)を全身の様々な組織で高発現するトランスジェニックマウスである。
Health Report No Data
Gene Details
Promoter CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)
1 Symbol Sphk1
Symbol name sphingosine kinase 1
Chromosome UN
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
提供条件 条件を付加する。
利用者は提供承諾書を用いて、事前に寄託者の承諾を得る。
研究成果の公表にあたって寄託者の指定する文献を引用する。
Cardiovasc Res. 2010 Feb 1;85(3):484-93. doi: 10.1093/cvr/cvp312
Additional information
1 No Data
Depositor 多久和 陽 (国立大学法人 金沢大学 大学院 医学系研究科) 多久和 陽
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
準備中につき、お問い合わせ下さい。
(提供までに6ヵ月以上を要する場合があります。)

Frozen
凍結胚のまま:即日~1か月
凍結胚から個体化:2か月~4か月

RBRC-KIT0033, KITOX-IDF17-WS

RBRC No. RBRC-KIT0033
Type Chemically-induced Mutation
Species Mus musculus
Strain name KITOX-IDF17-WS
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report No Data
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name No Data
Chromosome No Data
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
提供条件 条件を付加する。
利用者は事前に寄託者の提供承諾書を得る。
研究成果の公表にあたって謝辞の表明を必要とする。
Prior to filing for a patent, or intellectual property or other rights based on results of research using the BIOLOGICAL RESOURCE, the RECIPIENT shall acquire the consent from the DEPOSITOR for such application. Use of the BIOLOGICAL RESOURCE shall be limited to a collaborative research. And Use of the BIOLOGICAL RESOURCE shall require co-authorship of the DEPOSITOR for TWO years after deposition of the BIOLOGICAL RESOURCE to the RIKEN BRC or for the first publication if no publication is made within the TWO years.
Additional information
1 Korea Institute of Toxicology HP
Depositor Song, Chang-Woo (Korea Institute of Toxicology) Song, Chang-Woo
Strain Status /
Availability
(Expected delivery)


Frozen
凍結胚のまま:即日~1か月
凍結胚から個体化:2か月~4か月

RBRC-KIT0032, KITOX-EM04-HT

RBRC No. RBRC-KIT0032
Type Chemically-induced Mutation
Species Mus musculus
Strain name KITOX-EM04-HT
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name No Data
Chromosome No Data
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
提供条件 条件を付加する。
利用者は事前に寄託者の提供承諾書を得る。
研究成果の公表にあたって謝辞の表明を必要とする。
Prior to filing for a patent, or intellectual property or other rights based on results of research using the BIOLOGICAL RESOURCE, the RECIPIENT shall acquire the consent from the DEPOSITOR for such application. Use of the BIOLOGICAL RESOURCE shall be limited to a collaborative research. And Use of the BIOLOGICAL RESOURCE shall require co-authorship of the DEPOSITOR for TWO years after deposition of the BIOLOGICAL RESOURCE to the RIKEN BRC or for the first publication if no publication is made within the TWO years.
Additional information
1 Korea Institute of Toxicology HP
Depositor Song, Chang-Woo (Korea Institute of Toxicology) Song, Chang-Woo
Strain Status /
Availability
(Expected delivery)


Frozen
凍結胚のまま:即日~1か月
凍結胚から個体化:2か月~4か月

RBRC-KIT0030, KITOX-BM36-LW

RBRC No. RBRC-KIT0030
Type Chemically-induced Mutation
Species Mus musculus
Strain name KITOX-BM36-LW
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name No Data
Chromosome No Data
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
提供条件 条件を付加する。
利用者は事前に寄託者の提供承諾書を得る。
研究成果の公表にあたって謝辞の表明を必要とする。
Prior to filing for a patent, or intellectual property or other rights based on results of research using the BIOLOGICAL RESOURCE, the RECIPIENT shall acquire the consent from the DEPOSITOR for such application. Use of the BIOLOGICAL RESOURCE shall be limited to a collaborative research. And Use of the BIOLOGICAL RESOURCE shall require co-authorship of the DEPOSITOR for TWO years after deposition of the BIOLOGICAL RESOURCE to the RIKEN BRC or for the first publication if no publication is made within the TWO years.
Additional information
1 Korea Institute of Toxicology HP
Depositor Song, Chang-Woo (Korea Institute of Toxicology) Song, Chang-Woo
Strain Status /
Availability
(Expected delivery)


Frozen
凍結胚のまま:即日~1か月
凍結胚から個体化:2か月~4か月

RBRC-KIT0029, KITOX-BM24-HP

RBRC No. RBRC-KIT0029
Type Chemically-induced Mutation wks
Species Mus musculus
Strain name KITOX-BM24-HP
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name No Data
Chromosome No Data
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
提供条件 条件を付加する。
利用者は事前に寄託者の提供承諾書を得る。
研究成果の公表にあたって謝辞の表明を必要とする。
Prior to filing for a patent, or intellectual property or other rights based on results of research using the BIOLOGICAL RESOURCE, the RECIPIENT shall acquire the consent from the DEPOSITOR for such application. Use of the BIOLOGICAL RESOURCE shall be limited to a collaborative research. And Use of the BIOLOGICAL RESOURCE shall require co-authorship of the DEPOSITOR for TWO years after deposition of the BIOLOGICAL RESOURCE to the RIKEN BRC or for the first publication if no publication is made within the TWO years.
Additional information
1 Korea Institute of Toxicology HP
Depositor Song, Chang-Woo (Korea Institute of Toxicology) Song, Chang-Woo
Strain Status /
Availability
(Expected delivery)


Frozen
凍結胚のまま:即日~1か月
凍結胚から個体化:2か月~4か月

RBRC-KIT0028, KITOX-BM15-Mu

RBRC No. RBRC-KIT0028
Type Chemically-induced Mutation
Species Mus musculus
Strain name KITOX-BM15-Mu
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Chang-Woo Song and Jae-Woo Cho, Korea Institute of Toxicology in Korea Research Institute of Chemical Technology. Mutant mice were crossed to BALB/c.
Strain description Homozygous mutant mice resemble hairless rhino mice in which no hair regeneration occurs and skin tissue is extensively folded. A mutation in the human homolog of Hr (HR; OMIM602302) , are known to cause congenital hairless disease, alopecia universalis congenita (OMIM602302). The Depositors are welcome to collaborate further detailed analyses on this mutant mouse. Series of other ENU-mutant mice with interesting phenotypes have also been deposited to RIKEN BRC.
Colony maintenance Heterozygote (male) x Homozygote (female) Homozygous mutant females have nurturing young, possibly as a result of defects in lactation.
Health Report
Gene Details
Promoter No Data
1 Symbol Hr
Symbol name hairless
Chromosome 14
Common name Hr
Symbol description No Data
References No Data

Research applications No Data
提供条件 条件を付加する。
利用者は事前に寄託者の提供承諾書を得る。
研究成果の公表にあたって謝辞の表明を必要とする。
Prior to filing for a patent, or intellectual property or other rights based on results of research using the BIOLOGICAL RESOURCE, the RECIPIENT shall acquire the consent from the DEPOSITOR for such application. Use of the BIOLOGICAL RESOURCE shall be limited to a collaborative research. And Use of the BIOLOGICAL RESOURCE shall require co-authorship of the DEPOSITOR for TWO years after deposition of the BIOLOGICAL RESOURCE to the RIKEN BRC or for the first publication if no publication is made within the TWO years.
Additional information
1 Mouse of the Month Apr 2005
2 Korea Institute of Toxicology HP
Depositor Song, Chang-Woo (Korea Institute of Toxicology) Song, Chang-Woo
Strain Status /
Availability
(Expected delivery)


Frozen
凍結胚のまま:即日~1か月
凍結胚から個体化:2か月~4か月

RBRC-KIT0027, KITOX-AM15-Cr

RBRC No. RBRC-KIT0027
Type Chemically-induced Mutation
Species Mus musculus
Strain name KITOX-AM15-Cr
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name No Data
Chromosome No Data
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
提供条件 条件を付加する。
利用者は事前に寄託者の提供承諾書を得る。
研究成果の公表にあたって謝辞の表明を必要とする。
Prior to filing for a patent, or intellectual property or other rights based on results of research using the BIOLOGICAL RESOURCE, the RECIPIENT shall acquire the consent from the DEPOSITOR for such application. Use of the BIOLOGICAL RESOURCE shall be limited to a collaborative research. And Use of the BIOLOGICAL RESOURCE shall require co-authorship of the DEPOSITOR for TWO years after deposition of the BIOLOGICAL RESOURCE to the RIKEN BRC or for the first publication if no publication is made within the TWO years.
Additional information
1 Korea Institute of Toxicology HP
Depositor Song, Chang-Woo (Korea Institute of Toxicology) Song, Chang-Woo
Strain Status /
Availability
(Expected delivery)


Frozen
凍結胚のまま:即日~1か月
凍結胚から個体化:2か月~4か月

RBRC-KIT0025, KITOX-LDM05-WS

RBRC No. RBRC-KIT0025
Type Chemically-induced Mutation
Species Mus musculus
Strain name KITOX-LDM05-WS
Former Common name No Data
H-2 Haplotype No Data
Background strain C57BL/6
Appearance
1 Appearance No Data
Genotype No Data
Strain development Background :C57BL/6
Generation:3
Strain description Phenotype : White spot
Phenotype : White spot
Colony maintenance Optimal Crosstype (male / female): Anyway
Health Report
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name No Data
Chromosome No Data
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
提供条件 条件を付加する。
利用者は事前に寄託者の提供承諾書を得る。
研究成果の公表にあたって謝辞の表明を必要とする。
Prior to filing for a patent, or intellectual property or other rights based on results of research using the BIOLOGICAL RESOURCE, the RECIPIENT shall acquire the consent from the DEPOSITOR for such application. Use of the BIOLOGICAL RESOURCE shall be limited to a collaborative research. And Use of the BIOLOGICAL RESOURCE shall require co-authorship of the DEPOSITOR for TWO years after deposition of the BIOLOGICAL RESOURCE to the RIKEN BRC or for the first publication if no publication is made within the TWO years.
Additional information
1 Korea Institute of Toxicology HP
Depositor Song, Chang-Woo (Korea Institute of Toxicology) Song, Chang-Woo
Strain Status /
Availability
(Expected delivery)


Frozen
凍結胚のまま:即日~1か月
凍結胚から個体化:2か月~4か月

RBRC-KIT0024, KITOX-LDM04-WS

RBRC No. RBRC-KIT0024
Type Chemically-induced Mutation
Species Mus musculus
Strain name KITOX-LDM04-WS
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Background :C57BL/6
Generation:3
Strain description Phenotype : White spot
Phenotype : White spot
Colony maintenance Optimal Crosstype (male / female): Anyway
Health Report
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name No Data
Chromosome No Data
Common name No Data
Symbol description No Data
References No Data

Research applications No Data
提供条件 条件を付加する。
利用者は事前に寄託者の提供承諾書を得る。
研究成果の公表にあたって謝辞の表明を必要とする。
Prior to filing for a patent, or intellectual property or other rights based on results of research using the BIOLOGICAL RESOURCE, the RECIPIENT shall acquire the consent from the DEPOSITOR for such application. Use of the BIOLOGICAL RESOURCE shall be limited to a collaborative research. And Use of the BIOLOGICAL RESOURCE shall require co-authorship of the DEPOSITOR for TWO years after deposition of the BIOLOGICAL RESOURCE to the RIKEN BRC or for the first publication if no publication is made within the TWO years.
Additional information
1 Korea Institute of Toxicology HP
Depositor Song, Chang-Woo (Korea Institute of Toxicology) Song, Chang-Woo
Strain Status /
Availability
(Expected delivery)


Frozen
凍結胚のまま:即日~1か月
凍結胚から個体化:2か月~4か月