RBRC01106, ICR.Cg-Sema3a<tm1.2Tyag>/TyagRbrc

RBRC No. RBRC01106
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name ICR.Cg-Sema3a<tm1.2Tyag>/TyagRbrc
Former Common name semaphorin III/D (conditional) Targeting mice
H-2 Haplotype No Data
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Donor strain (C57BL/6 x CBA)F1 via TT2 ES cell line
Background strain Jcl:ICR
1 Appearance albino
Genotype c/c
Strain development 生理学研究所·谷口 雅彦先生、八木 健先生(1997)。TT2 ES細胞を用いて作出。ICR混合背景。
Strain description Semaphorin III/D (Sema3a) 遺伝子のfloxedマウス。Nullアレル (RBRC01104) 、lacZアレル (RBRC01105) 、floxedアレル (RBRC01106) 。
Semaphorin III/D (Sema3a) floxed mice Homozygous mutant mice are viable and fertile.
Colony maintenance Homozygote x Homozygote [or Crossing to Jcl:ICR]
Health Report
Gene Details
Promoter No Data
1 Symbol Sema3a
Symbol name semaphorin III
Chromosome 5
Common name coll-1, collapsin-1, Hsema-I, sema III, SEMA1, Semad, semaphorin III, SemD, SemD
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 5
Common name No Data
Symbol description No Data
3 Symbol loxP
Symbol name phage P1 loxP
Chromosome 5
Common name No Data
Symbol description No Data
References Neuron. 1997 Sep;19(3):519-30.

Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection.
Research applications Cre/loxP system,
Neurobiology Research
提供条件 条件を付加する。
Neuron, 19, 519-530 (1997).
Additional information
1 Lab HP (Japanese)
2 Mouse of the Month Aug 2006
3 Genotyping protocol <PCR>
Depositor 八木 健 (大学共同利用機関法人 自然科学研究機構) 八木 健
Strain Status /
(Expected delivery)



BRC mice in Publications
Title Journal
Sema3A regulates bone-mass accrual through sensory innervations. Nature. (2013).(23644455)
Fukuda T, Takeda S, Xu R, Ochi H, Sunamura S, Sato T, Shibata S, Yoshida Y, Gu Z, Kimura A, Ma C, Xu C, Bando W, Fujita K, Shinomiya K, Hirai T, Asou Y, Enomoto M, Okano H, Okawa A, Itoh H.
Axon position within the corpus callosum determines contralateral cortical projection. Proc Natl Acad Sci U S A. (2013).(23812756)
Zhou J, Wen Y, She L, Sui YN, Liu L, Richards LJ, Poo MM.
Semaphorin3A Signaling Is Dispensable for Motor Axon Reinnervation of the Adult Neuromuscular Junction. eNeuro (2018).(29774231)
J. L. Shadrach, and B. A. Pierchala.